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Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model.
JPEN J Parenter Enteral Nutr. 1996 Nov-Dec; 20(6):417-23.JJ

Abstract

BACKGROUND

The effects of glutamine-enriched total parenteral nutrition (TPN) solution on survival, and protein turnover in the whole body and in individual organs were investigated in a rat protracted peritonitis model.

METHODS

Twenty-three rats underwent venous catheter insertion. Osmotic pumps were implanted in the peritoneal cavity to allow continuous delivery of Escherichia coli (4 x 10(8) CFU/d). The conventional TPN group received a conventional amino acid solution. The Ala-Gln TPN group received an alanyl-glutamine-enriched TPN solution. The two TPN solutions were isocaloric and isonitrogenous.

RESULTS

Over the 5 days of TPN treatment, the survival rate of the Ala-Gln group was significantly higher than that of the conventional group. The Ala-Gln group tended to have increased whole-body protein turnover compared with the conventional group. Fractional protein synthetic rates (FSR) in the liver and gastrocnemius muscle of the Ala-Gln group were significantly higher than those of the conventional group. The serum glutamine concentration correlated positively with the FSR of both liver and muscle. The Ala-Gln group showed significantly greater mucosal height and mitoses per crypt, in the small intestine, than did the conventional group.

CONCLUSIONS

Our results suggested that, in comparison with standard glutamine-free TPN, Ala-Gln-supplemented TPN increases protein synthesis in the liver and skeletal muscle, protects the morphology of the intestinal mucosa, and improves survival in protracted bacterial peritonitis. Ala-Gln supplementation may be useful in septic patients.

Authors+Show Affiliations

Department of Surgery, Faculty of Medicine, University of Tokyo, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8950743

Citation

Naka, S, et al. "Alanyl-glutamine-supplemented Total Parenteral Nutrition Improves Survival and Protein Metabolism in Rat Protracted Bacterial Peritonitis Model." JPEN. Journal of Parenteral and Enteral Nutrition, vol. 20, no. 6, 1996, pp. 417-23.
Naka S, Saito H, Hashiguchi Y, et al. Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. JPEN J Parenter Enteral Nutr. 1996;20(6):417-23.
Naka, S., Saito, H., Hashiguchi, Y., Lin, M. T., Furukawa, S., Inaba, T., Fukushima, R., Wada, N., & Muto, T. (1996). Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. JPEN. Journal of Parenteral and Enteral Nutrition, 20(6), 417-23.
Naka S, et al. Alanyl-glutamine-supplemented Total Parenteral Nutrition Improves Survival and Protein Metabolism in Rat Protracted Bacterial Peritonitis Model. JPEN J Parenter Enteral Nutr. 1996 Nov-Dec;20(6):417-23. PubMed PMID: 8950743.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Alanyl-glutamine-supplemented total parenteral nutrition improves survival and protein metabolism in rat protracted bacterial peritonitis model. AU - Naka,S, AU - Saito,H, AU - Hashiguchi,Y, AU - Lin,M T, AU - Furukawa,S, AU - Inaba,T, AU - Fukushima,R, AU - Wada,N, AU - Muto,T, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 417 EP - 23 JF - JPEN. Journal of parenteral and enteral nutrition JO - JPEN J Parenter Enteral Nutr VL - 20 IS - 6 N2 - BACKGROUND: The effects of glutamine-enriched total parenteral nutrition (TPN) solution on survival, and protein turnover in the whole body and in individual organs were investigated in a rat protracted peritonitis model. METHODS: Twenty-three rats underwent venous catheter insertion. Osmotic pumps were implanted in the peritoneal cavity to allow continuous delivery of Escherichia coli (4 x 10(8) CFU/d). The conventional TPN group received a conventional amino acid solution. The Ala-Gln TPN group received an alanyl-glutamine-enriched TPN solution. The two TPN solutions were isocaloric and isonitrogenous. RESULTS: Over the 5 days of TPN treatment, the survival rate of the Ala-Gln group was significantly higher than that of the conventional group. The Ala-Gln group tended to have increased whole-body protein turnover compared with the conventional group. Fractional protein synthetic rates (FSR) in the liver and gastrocnemius muscle of the Ala-Gln group were significantly higher than those of the conventional group. The serum glutamine concentration correlated positively with the FSR of both liver and muscle. The Ala-Gln group showed significantly greater mucosal height and mitoses per crypt, in the small intestine, than did the conventional group. CONCLUSIONS: Our results suggested that, in comparison with standard glutamine-free TPN, Ala-Gln-supplemented TPN increases protein synthesis in the liver and skeletal muscle, protects the morphology of the intestinal mucosa, and improves survival in protracted bacterial peritonitis. Ala-Gln supplementation may be useful in septic patients. SN - 0148-6071 UR - https://www.unboundmedicine.com/medline/citation/8950743/Alanyl_glutamine_supplemented_total_parenteral_nutrition_improves_survival_and_protein_metabolism_in_rat_protracted_bacterial_peritonitis_model_ L2 - https://doi.org/10.1177/0148607196020006417 DB - PRIME DP - Unbound Medicine ER -