Tags

Type your tag names separated by a space and hit enter

[Thromboxane A2 receptor antagonist in asthma therapy].
Nihon Rinsho 1996; 54(11):3045-8NR

Abstract

Lung tissues produce a large amount of Thromboxane (Tx) A2. In addition to platelet aggregation and artery smooth muscle contraction, TxA2 strongly induces airway smooth muscle contraction and bronchial hyperresponsiveness. Not only TxA2, but many arachidonate cyclooxygenase metabolites such as PGD2, PGF2 alpha, PGH2, and others stimulate TP (PGH2/TxA2) receptor and can take a pathophysiological role for bronchial asthma. Several compounds competitively antagonizing TP receptor have been developed and being proved to have beneficial effects for treating of bronchial asthma in clinical. In this review the efficacy and usage of TP receptor antagonists for bronchial asthma was discussed.

Authors+Show Affiliations

Clinical Research Center for Allergy and Rheumatology, National Sagamihara Hospital.No affiliation info available

Pub Type(s)

Journal Article
Review

Language

jpn

PubMed ID

8950952

Citation

Endo, S, and K Akiyama. "[Thromboxane A2 Receptor Antagonist in Asthma Therapy]." Nihon Rinsho. Japanese Journal of Clinical Medicine, vol. 54, no. 11, 1996, pp. 3045-8.
Endo S, Akiyama K. [Thromboxane A2 receptor antagonist in asthma therapy]. Nippon Rinsho. 1996;54(11):3045-8.
Endo, S., & Akiyama, K. (1996). [Thromboxane A2 receptor antagonist in asthma therapy]. Nihon Rinsho. Japanese Journal of Clinical Medicine, 54(11), pp. 3045-8.
Endo S, Akiyama K. [Thromboxane A2 Receptor Antagonist in Asthma Therapy]. Nippon Rinsho. 1996;54(11):3045-8. PubMed PMID: 8950952.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Thromboxane A2 receptor antagonist in asthma therapy]. AU - Endo,S, AU - Akiyama,K, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 3045 EP - 8 JF - Nihon rinsho. Japanese journal of clinical medicine JO - Nippon Rinsho VL - 54 IS - 11 N2 - Lung tissues produce a large amount of Thromboxane (Tx) A2. In addition to platelet aggregation and artery smooth muscle contraction, TxA2 strongly induces airway smooth muscle contraction and bronchial hyperresponsiveness. Not only TxA2, but many arachidonate cyclooxygenase metabolites such as PGD2, PGF2 alpha, PGH2, and others stimulate TP (PGH2/TxA2) receptor and can take a pathophysiological role for bronchial asthma. Several compounds competitively antagonizing TP receptor have been developed and being proved to have beneficial effects for treating of bronchial asthma in clinical. In this review the efficacy and usage of TP receptor antagonists for bronchial asthma was discussed. SN - 0047-1852 UR - https://www.unboundmedicine.com/medline/citation/8950952/[Thromboxane_A2_receptor_antagonist_in_asthma_therapy]_ L2 - http://www.diseaseinfosearch.org/result/633 DB - PRIME DP - Unbound Medicine ER -