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Intravascularly applied K(+)-channel blockers suppress differently the positive endocochlear potential maintained by vascular perfusion.
Hear Res. 1996 Nov 01; 101(1-2):181-5.HR

Abstract

We studied the effects of several K+ channel blockers on the positive endocochlear potential (EP) of guinea pigs undergoing perfusion via the anterior inferior cerebellar artery. The EP level was reversibly suppressed by 50-60% in the presence of Ba2+ (2 mM), quinine (2 mM) or verapamil (1 mM) in the perfusate, but not significantly affected by tetraethylammonium (20 mM) or 4-aminopyridine (5 mM). Although the effective site(s) of these blockers at the cell level has not been located yet, these findings indicate an important role for a K+ conductance in the generation of the EP.

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Authors+Show Affiliations

Takeuchi S
Department of Physiology, Kochi Medical School, Nankoku, Japan.
Kakigi A
No affiliation info available
Takeda T
No affiliation info available
Saito H
No affiliation info available
Irimajiri A
No affiliation info available

MeSH

Analgesics, Non-NarcoticAnimalsBariumCalcium Channel BlockersCerebellumCochlear Microphonic PotentialsGuinea PigsPotassium Channel BlockersQuinineStria VascularisTetraethylammoniumTetraethylammonium CompoundsVerapamil

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8951443

Citation

Takeuchi, S, et al. "Intravascularly Applied K(+)-channel Blockers Suppress Differently the Positive Endocochlear Potential Maintained By Vascular Perfusion." Hearing Research, vol. 101, no. 1-2, 1996, pp. 181-5.
Takeuchi S, Kakigi A, Takeda T, et al. Intravascularly applied K(+)-channel blockers suppress differently the positive endocochlear potential maintained by vascular perfusion. Hear Res. 1996;101(1-2):181-5.
Takeuchi, S., Kakigi, A., Takeda, T., Saito, H., & Irimajiri, A. (1996). Intravascularly applied K(+)-channel blockers suppress differently the positive endocochlear potential maintained by vascular perfusion. Hearing Research, 101(1-2), 181-5.
Takeuchi S, et al. Intravascularly Applied K(+)-channel Blockers Suppress Differently the Positive Endocochlear Potential Maintained By Vascular Perfusion. Hear Res. 1996 Nov 1;101(1-2):181-5. PubMed PMID: 8951443.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Intravascularly applied K(+)-channel blockers suppress differently the positive endocochlear potential maintained by vascular perfusion. AU - Takeuchi,S, AU - Kakigi,A, AU - Takeda,T, AU - Saito,H, AU - Irimajiri,A, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 181 EP - 5 JF - Hearing research JO - Hear Res VL - 101 IS - 1-2 N2 - We studied the effects of several K+ channel blockers on the positive endocochlear potential (EP) of guinea pigs undergoing perfusion via the anterior inferior cerebellar artery. The EP level was reversibly suppressed by 50-60% in the presence of Ba2+ (2 mM), quinine (2 mM) or verapamil (1 mM) in the perfusate, but not significantly affected by tetraethylammonium (20 mM) or 4-aminopyridine (5 mM). Although the effective site(s) of these blockers at the cell level has not been located yet, these findings indicate an important role for a K+ conductance in the generation of the EP. SN - 0378-5955 UR - https://www.unboundmedicine.com/medline/citation/8951443/Intravascularly_applied_K_+__channel_blockers_suppress_differently_the_positive_endocochlear_potential_maintained_by_vascular_perfusion_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0378-5955(96)00151-7 DB - PRIME DP - Unbound Medicine ER -