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A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13.
Genomics. 1996 Dec 01; 38(2):166-73.G

Abstract

Linkage analysis and loss of heterozygosity studies have shown that the gene responsible for the multiple endocrine neoplasia type-1 (MEN1) syndrome localizes to a small interval between D11S427 and D11S460 on chromosome 11q13. As an initial step to clone this tumor suppressor gene, our group is the first to map the MEN1 region physically using yeast artificial chromosome, bacterial artificial chromosome (BAC), and cosmid contigs. The 1.5-Mb high-resolution, contiguous map extends from PYGM to 300 kb telomeric of D11S460. Of this, the 1.2-Mb interval between PYGM and D11S460 is isolated in cosmids and BACs and will be useful for the development of genomic sequences and transcription maps of this important region. Nine new sequence-tagged sites (STS) are also characterized from this region. The physical map and the STSs will be valuable tools for the cloning of the MEN1 gene.

Authors+Show Affiliations

Department of Surgery (W112), VAMC West Los Angeles, UCLA School of Medicine 90073, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8954798

Citation

Wood, T F., et al. "A 1.5-megabase Physical Map Encompassing the Multiple Endocrine Neoplasia Type-1 (MEN1) Locus On Chromosome 11q13." Genomics, vol. 38, no. 2, 1996, pp. 166-73.
Wood TF, Srivatsan ES, Chakrabarti R, et al. A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Genomics. 1996;38(2):166-73.
Wood, T. F., Srivatsan, E. S., Chakrabarti, R., Ma, G. C., Kuan, N., Samara, G. J., Higgins, M. J., Shows, T. B., Johnson, C. L., Wan, Y. J., Passaro, E. P., & Sawicki, M. P. (1996). A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. Genomics, 38(2), 166-73.
Wood TF, et al. A 1.5-megabase Physical Map Encompassing the Multiple Endocrine Neoplasia Type-1 (MEN1) Locus On Chromosome 11q13. Genomics. 1996 Dec 1;38(2):166-73. PubMed PMID: 8954798.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - A 1.5-megabase physical map encompassing the multiple endocrine neoplasia type-1 (MEN1) locus on chromosome 11q13. AU - Wood,T F, AU - Srivatsan,E S, AU - Chakrabarti,R, AU - Ma,G C, AU - Kuan,N, AU - Samara,G J, AU - Higgins,M J, AU - Shows,T B, AU - Johnson,C L, AU - Wan,Y J, AU - Passaro,E P,Jr AU - Sawicki,M P, PY - 1996/12/1/pubmed PY - 2001/3/28/medline PY - 1996/12/1/entrez SP - 166 EP - 73 JF - Genomics JO - Genomics VL - 38 IS - 2 N2 - Linkage analysis and loss of heterozygosity studies have shown that the gene responsible for the multiple endocrine neoplasia type-1 (MEN1) syndrome localizes to a small interval between D11S427 and D11S460 on chromosome 11q13. As an initial step to clone this tumor suppressor gene, our group is the first to map the MEN1 region physically using yeast artificial chromosome, bacterial artificial chromosome (BAC), and cosmid contigs. The 1.5-Mb high-resolution, contiguous map extends from PYGM to 300 kb telomeric of D11S460. Of this, the 1.2-Mb interval between PYGM and D11S460 is isolated in cosmids and BACs and will be useful for the development of genomic sequences and transcription maps of this important region. Nine new sequence-tagged sites (STS) are also characterized from this region. The physical map and the STSs will be valuable tools for the cloning of the MEN1 gene. SN - 0888-7543 UR - https://www.unboundmedicine.com/medline/citation/8954798/A_1_5_megabase_physical_map_encompassing_the_multiple_endocrine_neoplasia_type_1__MEN1__locus_on_chromosome_11q13_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0888754396906126 DB - PRIME DP - Unbound Medicine ER -