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Treatment of goitrous hypothyroidism with iodized oil supplementation in an area of iodine deficiency.
Exp Clin Endocrinol Diabetes 1996; 104(5):387-91EC

Abstract

In order to investigate the effect of iodized oil administration on the thyroid status of male hypothyroid children and adolescents residing in an area of iodine deficiency, 32 apparently normal school boys with increased serum TSH, aged 7 to 15 years, were given a single intramuscular injection of 480 mg iodized oil. Four months after injection, serum T4 increased from 60 +/- 23 to 118 +/- 24 nmol/l and serum TSH decreased from 39 +/- 33 to 2.5 +/- 1.2 mU/l. Serum T4 remained unchanged while a further decline in TSH to 1.3 +/- 0.9 and 1.4 +/- 1.3 mU/l was observed 7 and 12 months after injection, respectively. There was a small but significant reduction in serum T3, FT3I as well as in the prevalence and severity of goiter 1 year following iodine treatment. Neither the age of the subject nor the severity of hypothyroidism affected the thyroid response to iodine treatment. It is concluded that iodized oil injection is an effective and convenient treatment for goitrous hypothyroid youngsters in iodine deficient areas.

Authors+Show Affiliations

Endocrine Research Center, Shaheed Beheshti, University of Medical Sciences, Tehran, I.R. Iran.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8957274

Citation

Azizi, F, et al. "Treatment of Goitrous Hypothyroidism With Iodized Oil Supplementation in an Area of Iodine Deficiency." Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, vol. 104, no. 5, 1996, pp. 387-91.
Azizi F, Kimiagar M, Ghazi A, et al. Treatment of goitrous hypothyroidism with iodized oil supplementation in an area of iodine deficiency. Exp Clin Endocrinol Diabetes. 1996;104(5):387-91.
Azizi, F., Kimiagar, M., Ghazi, A., Nafarabadi, M., Behjati, J., & Esfahanian, F. (1996). Treatment of goitrous hypothyroidism with iodized oil supplementation in an area of iodine deficiency. Experimental and Clinical Endocrinology & Diabetes : Official Journal, German Society of Endocrinology [and] German Diabetes Association, 104(5), pp. 387-91.
Azizi F, et al. Treatment of Goitrous Hypothyroidism With Iodized Oil Supplementation in an Area of Iodine Deficiency. Exp Clin Endocrinol Diabetes. 1996;104(5):387-91. PubMed PMID: 8957274.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Treatment of goitrous hypothyroidism with iodized oil supplementation in an area of iodine deficiency. AU - Azizi,F, AU - Kimiagar,M, AU - Ghazi,A, AU - Nafarabadi,M, AU - Behjati,J, AU - Esfahanian,F, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 387 EP - 91 JF - Experimental and clinical endocrinology & diabetes : official journal, German Society of Endocrinology [and] German Diabetes Association JO - Exp. Clin. Endocrinol. Diabetes VL - 104 IS - 5 N2 - In order to investigate the effect of iodized oil administration on the thyroid status of male hypothyroid children and adolescents residing in an area of iodine deficiency, 32 apparently normal school boys with increased serum TSH, aged 7 to 15 years, were given a single intramuscular injection of 480 mg iodized oil. Four months after injection, serum T4 increased from 60 +/- 23 to 118 +/- 24 nmol/l and serum TSH decreased from 39 +/- 33 to 2.5 +/- 1.2 mU/l. Serum T4 remained unchanged while a further decline in TSH to 1.3 +/- 0.9 and 1.4 +/- 1.3 mU/l was observed 7 and 12 months after injection, respectively. There was a small but significant reduction in serum T3, FT3I as well as in the prevalence and severity of goiter 1 year following iodine treatment. Neither the age of the subject nor the severity of hypothyroidism affected the thyroid response to iodine treatment. It is concluded that iodized oil injection is an effective and convenient treatment for goitrous hypothyroid youngsters in iodine deficient areas. SN - 0947-7349 UR - https://www.unboundmedicine.com/medline/citation/8957274/Treatment_of_goitrous_hypothyroidism_with_iodized_oil_supplementation_in_an_area_of_iodine_deficiency_ L2 - http://www.thieme-connect.com/DOI/DOI?10.1055/s-0029-1211472 DB - PRIME DP - Unbound Medicine ER -