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CD22 regulates thymus-independent responses and the lifespan of B cells.
Nature. 1996 Dec 19-26; 384(6610):634-7.Nat

Abstract

The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells.

Authors+Show Affiliations

Department of Immunology, University of Washington Medical Center, Seattle 98195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8967951

Citation

Otipoby, K L., et al. "CD22 Regulates Thymus-independent Responses and the Lifespan of B Cells." Nature, vol. 384, no. 6610, 1996, pp. 634-7.
Otipoby KL, Andersson KB, Draves KE, et al. CD22 regulates thymus-independent responses and the lifespan of B cells. Nature. 1996;384(6610):634-7.
Otipoby, K. L., Andersson, K. B., Draves, K. E., Klaus, S. J., Farr, A. G., Kerner, J. D., Perlmutter, R. M., Law, C. L., & Clark, E. A. (1996). CD22 regulates thymus-independent responses and the lifespan of B cells. Nature, 384(6610), 634-7.
Otipoby KL, et al. CD22 Regulates Thymus-independent Responses and the Lifespan of B Cells. Nature. 1996 Dec 19-26;384(6610):634-7. PubMed PMID: 8967951.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - CD22 regulates thymus-independent responses and the lifespan of B cells. AU - Otipoby,K L, AU - Andersson,K B, AU - Draves,K E, AU - Klaus,S J, AU - Farr,A G, AU - Kerner,J D, AU - Perlmutter,R M, AU - Law,C L, AU - Clark,E A, PY - 1996/12/19/pubmed PY - 1996/12/19/medline PY - 1996/12/19/entrez SP - 634 EP - 7 JF - Nature JO - Nature VL - 384 IS - 6610 N2 - The B-lymphocyte-restricted glycoprotein CD22 is expressed on mature IgM+IgD+ B cells, and is capable of binding to ligands on T and B cells. CD22 can interact with both the B-cell antigen receptor (BCR) complex and signalling molecules, including the protein tyrosine phosphatase SHP1 (PTP1C, SHP), a putative negative regulator of BCR signalling. Thus CD22 may facilitate interactions with lymphocytes and regulate the threshold of BCR signalling. To define the in vivo function of CD22, we generated CD22-deficient mice. Here we show that CD22 is required for normal antibody responses to thymus-independent antigens and regulates the lifespan of mature B cells. SN - 0028-0836 UR - https://www.unboundmedicine.com/medline/citation/8967951/CD22_regulates_thymus_independent_responses_and_the_lifespan_of_B_cells_ L2 - https://doi.org/10.1038/384634a0 DB - PRIME DP - Unbound Medicine ER -