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Marihuana metabolites in urine of man. VII. Excretion patterns of acidic metabolites detected by sequential thin layer chromatography.
Res Commun Chem Pathol Pharmacol. 1977 Jul; 17(3):421-31.RC

Abstract

The 11-oic acid metabolites of delta-9-tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) can be identified presumptively in human urine using standard thin layer chromatographic procedures. Other acidic metabolites are also excreted but these are not yet identified. These acidic metabolites appear in urine soon after exposure but persist for at least 48 to 72 hours. Such long persistence does not permit their detection to be used for forensic purposes. Using only simple chemical methods, we have been able to identify presumptively the 11-oic acids of THC, CBN and CBD in the urine of persons taking these materials. A sequential thin-layer chromatography system we have devised provided the basis for this first report of such isolation without the use of labeled drug or mass spectrometric methods.

Links

patent databases

Authors

Kanter SL
No affiliation info available
Hollister LE
No affiliation info available

MeSH

CannabidiolCannabinoidsCannabinolCannabisChromatography, Thin LayerDronabinolHumansTime Factors

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

897336

Citation

Kanter, S L., and L E. Hollister. "Marihuana Metabolites in Urine of Man. VII. Excretion Patterns of Acidic Metabolites Detected By Sequential Thin Layer Chromatography." Research Communications in Chemical Pathology and Pharmacology, vol. 17, no. 3, 1977, pp. 421-31.
Kanter SL, Hollister LE. Marihuana metabolites in urine of man. VII. Excretion patterns of acidic metabolites detected by sequential thin layer chromatography. Res Commun Chem Pathol Pharmacol. 1977;17(3):421-31.
Kanter, S. L., & Hollister, L. E. (1977). Marihuana metabolites in urine of man. VII. Excretion patterns of acidic metabolites detected by sequential thin layer chromatography. Research Communications in Chemical Pathology and Pharmacology, 17(3), 421-31.
Kanter SL, Hollister LE. Marihuana Metabolites in Urine of Man. VII. Excretion Patterns of Acidic Metabolites Detected By Sequential Thin Layer Chromatography. Res Commun Chem Pathol Pharmacol. 1977;17(3):421-31. PubMed PMID: 897336.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Marihuana metabolites in urine of man. VII. Excretion patterns of acidic metabolites detected by sequential thin layer chromatography. AU - Kanter,S L, AU - Hollister,L E, PY - 1977/7/1/pubmed PY - 1977/7/1/medline PY - 1977/7/1/entrez SP - 421 EP - 31 JF - Research communications in chemical pathology and pharmacology JO - Res Commun Chem Pathol Pharmacol VL - 17 IS - 3 N2 - The 11-oic acid metabolites of delta-9-tetrahydrocannabinol (THC), cannabinol (CBN), and cannabidiol (CBD) can be identified presumptively in human urine using standard thin layer chromatographic procedures. Other acidic metabolites are also excreted but these are not yet identified. These acidic metabolites appear in urine soon after exposure but persist for at least 48 to 72 hours. Such long persistence does not permit their detection to be used for forensic purposes. Using only simple chemical methods, we have been able to identify presumptively the 11-oic acids of THC, CBN and CBD in the urine of persons taking these materials. A sequential thin-layer chromatography system we have devised provided the basis for this first report of such isolation without the use of labeled drug or mass spectrometric methods. SN - 0034-5164 UR - https://www.unboundmedicine.com/medline/citation/897336/Marihuana_metabolites_in_urine_of_man__VII__Excretion_patterns_of_acidic_metabolites_detected_by_sequential_thin_layer_chromatography_ L2 - https://www.lens.org/lens/search/patent/list?q=citation_id:897336 DB - PRIME DP - Unbound Medicine ER -