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Cytochemical effects of in vitro dopamine treatment on the Na-KATPase activity in strial marginal cells.
Acta Otolaryngol. 1996 Nov; 116(6):824-7.AO

Abstract

Dopamine is often used clinically for the treatment of patients with shock. In a previous study, the Na-KATPase (K-NPPase) activity of strial marginal cells was inhibited after the repeated in vivo administration of dopamine hydrochloride. In the present study, the K-NPPase activity of strial marginal cells was determined using a cerium-based cytochemistry after an in vitro incubation with dopamine. The enzyme reaction product was found in untreated normal strial marginal cells, but it was almost completely undetectable after an in vitro treatment with 10 mM dopamine. This finding suggested that dopamine directly inhibited the Na-KATPase activity of strial marginal cells, and that these cells might have a dopamine receptor.

Authors+Show Affiliations

Department of Otolaryngology, Hyogo College of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8973714

Citation

Kanoh, N, et al. "Cytochemical Effects of in Vitro Dopamine Treatment On the Na-KATPase Activity in Strial Marginal Cells." Acta Oto-laryngologica, vol. 116, no. 6, 1996, pp. 824-7.
Kanoh N, Ogasawara H, Mohri D, et al. Cytochemical effects of in vitro dopamine treatment on the Na-KATPase activity in strial marginal cells. Acta Otolaryngol. 1996;116(6):824-7.
Kanoh, N., Ogasawara, H., Mohri, D., Fukazawa, K., & Sakagami, M. (1996). Cytochemical effects of in vitro dopamine treatment on the Na-KATPase activity in strial marginal cells. Acta Oto-laryngologica, 116(6), 824-7.
Kanoh N, et al. Cytochemical Effects of in Vitro Dopamine Treatment On the Na-KATPase Activity in Strial Marginal Cells. Acta Otolaryngol. 1996;116(6):824-7. PubMed PMID: 8973714.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytochemical effects of in vitro dopamine treatment on the Na-KATPase activity in strial marginal cells. AU - Kanoh,N, AU - Ogasawara,H, AU - Mohri,D, AU - Fukazawa,K, AU - Sakagami,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 824 EP - 7 JF - Acta oto-laryngologica JO - Acta Otolaryngol VL - 116 IS - 6 N2 - Dopamine is often used clinically for the treatment of patients with shock. In a previous study, the Na-KATPase (K-NPPase) activity of strial marginal cells was inhibited after the repeated in vivo administration of dopamine hydrochloride. In the present study, the K-NPPase activity of strial marginal cells was determined using a cerium-based cytochemistry after an in vitro incubation with dopamine. The enzyme reaction product was found in untreated normal strial marginal cells, but it was almost completely undetectable after an in vitro treatment with 10 mM dopamine. This finding suggested that dopamine directly inhibited the Na-KATPase activity of strial marginal cells, and that these cells might have a dopamine receptor. SN - 0001-6489 UR - https://www.unboundmedicine.com/medline/citation/8973714/Cytochemical_effects_of_in_vitro_dopamine_treatment_on_the_Na_KATPase_activity_in_strial_marginal_cells_ L2 - https://www.tandfonline.com/doi/full/10.3109/00016489609137933 DB - PRIME DP - Unbound Medicine ER -