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Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis.
J Pathol. 1996 Oct; 180(2):181-7.JP

Abstract

The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited tissue-specific expression in both eutopic and ectopic endometrium. Integrin alpha 3 subunit was up-regulated in ectopic endometrium compared with the eutopic counterpart, whereas alpha 6 integrin subunit was down-regulated in the ectopic tissues. Cycle stage-dependent expression of alpha v and beta 3, observed in eutopic endometrium, was absent in the ectopic counterpart. It is concluded that the development and regeneration of the endometrium involve complex integrin-ligand interactions and that regulation of specific adhesive events is lost in endometriosis.

Authors+Show Affiliations

Nuffield Department of Obstetrics and Gynaecology, John Radcliffe Hospital, Headington, Oxford OX39DC, U.K.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8976878

Citation

Rai, V, et al. "Integrins Alpha 3 and Alpha 6 Are Differentially Expressed in Endometrium and Endometriosis." The Journal of Pathology, vol. 180, no. 2, 1996, pp. 181-7.
Rai V, Hopkisson J, Kennedy S, et al. Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis. J Pathol. 1996;180(2):181-7.
Rai, V., Hopkisson, J., Kennedy, S., Bergqvist, A., Barlow, D. H., & Mardon, H. J. (1996). Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis. The Journal of Pathology, 180(2), 181-7.
Rai V, et al. Integrins Alpha 3 and Alpha 6 Are Differentially Expressed in Endometrium and Endometriosis. J Pathol. 1996;180(2):181-7. PubMed PMID: 8976878.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Integrins alpha 3 and alpha 6 are differentially expressed in endometrium and endometriosis. AU - Rai,V, AU - Hopkisson,J, AU - Kennedy,S, AU - Bergqvist,A, AU - Barlow,D H, AU - Mardon,H J, PY - 1996/10/1/pubmed PY - 2000/6/20/medline PY - 1996/10/1/entrez SP - 181 EP - 7 JF - The Journal of pathology JO - J. Pathol. VL - 180 IS - 2 N2 - The expression of integrin subunits has been investigated in the stroma and epithelium of eutopic and ectopic endometrial tissues, using immunohistochemistry and fluorescently activated cell-sorting techniques. Integrin subunits exhibited tissue-specific expression in both eutopic and ectopic endometrium. Integrin alpha 3 subunit was up-regulated in ectopic endometrium compared with the eutopic counterpart, whereas alpha 6 integrin subunit was down-regulated in the ectopic tissues. Cycle stage-dependent expression of alpha v and beta 3, observed in eutopic endometrium, was absent in the ectopic counterpart. It is concluded that the development and regeneration of the endometrium involve complex integrin-ligand interactions and that regulation of specific adhesive events is lost in endometriosis. SN - 0022-3417 UR - https://www.unboundmedicine.com/medline/citation/8976878/Integrins_alpha_3_and_alpha_6_are_differentially_expressed_in_endometrium_and_endometriosis_ L2 - https://doi.org/10.1002/(SICI)1096-9896(199610)180:2<181::AID-PATH620>3.0.CO;2-I DB - PRIME DP - Unbound Medicine ER -