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Androgens and the menopause; a study of 40-60-year-old women.
Clin Endocrinol (Oxf). 1996 Nov; 45(5):577-87.CE

Abstract

OBJECTIVE

The impact of the menopause on androgen production is poorly understood. We have investigated the impact of the menopause, as well as other factors such as age, body mass index (BMI) and cigarette smoking, on ovarian and adrenal androgen levels in women aged 40-60 years.

DESIGN

Cross-sectional study of blood hormones sampled weekly over one month in volunteer 40-60-year-old women.

SUBJECTS

One hundred and forty-one women, aged between 40 and 60, recruited from community sources (non-clinical), not using hormone replacement or steroidal contraceptives, and with a current sexual partner. Fifty were categorized as premenopausal (ovulating), 37 as perimenopausal and 54 as post-menopausal.

MEASUREMENTS

The following variables were assessed; menopausal status (based on menstrual history and pattern and plasma progesterone), age, BMI, smoking, oestradiol (E2), oestrone (E1), LH, FSH, total testosterone (TT), androstenedione (A), SHBG, free androgen index (FAI), dihydroepiandrosterone (DHEA), dihydroepiandrosterone sulphate (DHEAS) and cortisol.

RESULTS

are based on multiple regression analysis. TT was positively related to A, BMI and LH. A was negatively related to age and FSH, and positively to DHEA, DHEAS and premenopausal status. SHBG was negatively related to BMI and positively to E1 and non-smoking. DHEA and DHEAS were negatively related to age and were higher in smokers. Both E1 and E2 were related to menopausal status and to FSH. Surprisingly, E2 was negatively related to BMI.

CONCLUSIONS

A variety of factors influence androgen production in this age group. Whereas it is difficult to predict the effect of menopause on androgen levels, LH stimulation of post-menopausal interstitial cells, modulated by a variety of factors including nutrition, and smoking, are likely to be relevant.

Authors+Show Affiliations

MRC Reproductive Biology Unit, Edinburgh, UK.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8977755

Citation

Bancroft, J, and E H. Cawood. "Androgens and the Menopause; a Study of 40-60-year-old Women." Clinical Endocrinology, vol. 45, no. 5, 1996, pp. 577-87.
Bancroft J, Cawood EH. Androgens and the menopause; a study of 40-60-year-old women. Clin Endocrinol (Oxf). 1996;45(5):577-87.
Bancroft, J., & Cawood, E. H. (1996). Androgens and the menopause; a study of 40-60-year-old women. Clinical Endocrinology, 45(5), 577-87.
Bancroft J, Cawood EH. Androgens and the Menopause; a Study of 40-60-year-old Women. Clin Endocrinol (Oxf). 1996;45(5):577-87. PubMed PMID: 8977755.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Androgens and the menopause; a study of 40-60-year-old women. AU - Bancroft,J, AU - Cawood,E H, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 577 EP - 87 JF - Clinical endocrinology JO - Clin Endocrinol (Oxf) VL - 45 IS - 5 N2 - OBJECTIVE: The impact of the menopause on androgen production is poorly understood. We have investigated the impact of the menopause, as well as other factors such as age, body mass index (BMI) and cigarette smoking, on ovarian and adrenal androgen levels in women aged 40-60 years. DESIGN: Cross-sectional study of blood hormones sampled weekly over one month in volunteer 40-60-year-old women. SUBJECTS: One hundred and forty-one women, aged between 40 and 60, recruited from community sources (non-clinical), not using hormone replacement or steroidal contraceptives, and with a current sexual partner. Fifty were categorized as premenopausal (ovulating), 37 as perimenopausal and 54 as post-menopausal. MEASUREMENTS: The following variables were assessed; menopausal status (based on menstrual history and pattern and plasma progesterone), age, BMI, smoking, oestradiol (E2), oestrone (E1), LH, FSH, total testosterone (TT), androstenedione (A), SHBG, free androgen index (FAI), dihydroepiandrosterone (DHEA), dihydroepiandrosterone sulphate (DHEAS) and cortisol. RESULTS: are based on multiple regression analysis. TT was positively related to A, BMI and LH. A was negatively related to age and FSH, and positively to DHEA, DHEAS and premenopausal status. SHBG was negatively related to BMI and positively to E1 and non-smoking. DHEA and DHEAS were negatively related to age and were higher in smokers. Both E1 and E2 were related to menopausal status and to FSH. Surprisingly, E2 was negatively related to BMI. CONCLUSIONS: A variety of factors influence androgen production in this age group. Whereas it is difficult to predict the effect of menopause on androgen levels, LH stimulation of post-menopausal interstitial cells, modulated by a variety of factors including nutrition, and smoking, are likely to be relevant. SN - 0300-0664 UR - https://www.unboundmedicine.com/medline/citation/8977755/Androgens_and_the_menopause L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0300-0664&date=1996&volume=45&issue=5&spage=577 DB - PRIME DP - Unbound Medicine ER -