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Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep.
Exp Lung Res. 1996 Nov-Dec; 22(6):613-25.EL

Abstract

To investigate the role played by neutrophil-derived elastase in acute lung injury, this study examined the effects of treatment of ONO-5046, a competitive, reversible, and specific neutrophil elastase inhibitor, on lung dysfunction induced by air emboli in awake sheep. Sheep were prepared with chronic lung lymph fistula. In experiment 1, air (1.23 mL/min) was infused over a 2-h period into the pulmonary artery and hemodynamic monitoring was performed over a 5-h period. In experiment 2, air was infused in the same manner as in experiment 1, 1 h after the continuous infusion of ONO-5046 (10 mg/kg h-1) had begun. In experiment 1, pulmonary artery pressure (Ppa) increased from the baseline value of 17.0 +/- 0.7 cm H2O to 28.3 +/- 1.8 1 h after the beginning of the air infusion. Ppa returned to the baseline values within 1 h after the air infusion was stopped. Lung lymph flow (Qlym) increased from the baseline value of 3.7 +/- 0.7 mL/0.5 h to 8.5 +/- 1.9 after 1 h of air infusion. After the air infusion was stopped, Qlym continued to increase. When sheep were treated with ONO-5046, Ppa and Qlym increased in a fashion similar to that in the experiment 1. These findings suggest that ONO-5046 does not attenuate air embolism-induced lung injury and that neutrophil-derived elastase may not play an important role in air embolism-induced lung injury in awake sheep.

Authors+Show Affiliations

1st Department of Internal Medicine, Shinshu University School of Medicine, Matsumoto City, Japan.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8979046

Citation

Miyahara, T, et al. "Specific Neutrophil Elastase Inhibitor Does Not Attenuate Acute Lung Injury Induced By Air Embolism in Awake Sheep." Experimental Lung Research, vol. 22, no. 6, 1996, pp. 613-25.
Miyahara T, Kubo K, Koizumi T, et al. Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. Exp Lung Res. 1996;22(6):613-25.
Miyahara, T., Kubo, K., Koizumi, T., Kobayashi, T., & Sekiguchi, M. (1996). Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. Experimental Lung Research, 22(6), 613-25.
Miyahara T, et al. Specific Neutrophil Elastase Inhibitor Does Not Attenuate Acute Lung Injury Induced By Air Embolism in Awake Sheep. Exp Lung Res. 1996 Nov-Dec;22(6):613-25. PubMed PMID: 8979046.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Specific neutrophil elastase inhibitor does not attenuate acute lung injury induced by air embolism in awake sheep. AU - Miyahara,T, AU - Kubo,K, AU - Koizumi,T, AU - Kobayashi,T, AU - Sekiguchi,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 613 EP - 25 JF - Experimental lung research JO - Exp Lung Res VL - 22 IS - 6 N2 - To investigate the role played by neutrophil-derived elastase in acute lung injury, this study examined the effects of treatment of ONO-5046, a competitive, reversible, and specific neutrophil elastase inhibitor, on lung dysfunction induced by air emboli in awake sheep. Sheep were prepared with chronic lung lymph fistula. In experiment 1, air (1.23 mL/min) was infused over a 2-h period into the pulmonary artery and hemodynamic monitoring was performed over a 5-h period. In experiment 2, air was infused in the same manner as in experiment 1, 1 h after the continuous infusion of ONO-5046 (10 mg/kg h-1) had begun. In experiment 1, pulmonary artery pressure (Ppa) increased from the baseline value of 17.0 +/- 0.7 cm H2O to 28.3 +/- 1.8 1 h after the beginning of the air infusion. Ppa returned to the baseline values within 1 h after the air infusion was stopped. Lung lymph flow (Qlym) increased from the baseline value of 3.7 +/- 0.7 mL/0.5 h to 8.5 +/- 1.9 after 1 h of air infusion. After the air infusion was stopped, Qlym continued to increase. When sheep were treated with ONO-5046, Ppa and Qlym increased in a fashion similar to that in the experiment 1. These findings suggest that ONO-5046 does not attenuate air embolism-induced lung injury and that neutrophil-derived elastase may not play an important role in air embolism-induced lung injury in awake sheep. SN - 0190-2148 UR - https://www.unboundmedicine.com/medline/citation/8979046/Specific_neutrophil_elastase_inhibitor_does_not_attenuate_acute_lung_injury_induced_by_air_embolism_in_awake_sheep_ L2 - https://www.tandfonline.com/doi/full/10.3109/01902149609070033 DB - PRIME DP - Unbound Medicine ER -