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Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis.
Allergol Immunopathol (Madr). 1979 May-Jun; 7(3):211-6.AI

Abstract

The pharmacological activity of vitamin C and the antiallergic drug disodium cromoglycate are compared in models of rat mast cell degranulation and histamine release, and in protracted anaphylactic shock in the guinea pig. Our results demonstrate that ascorbic acid has a very weak inhibitory effect on degranulation and histamine release from mast cells, and therefore cannot be considered a prophylactic antiallergic drug such as disodium cromoglycate.

Authors

González RG
No affiliation info available
García M
No affiliation info available
Pérez Saad H
No affiliation info available
de la Vega AR
No affiliation info available

MeSH

AnaphylaxisAnimalsAscitic FluidAscorbic AcidClinical Trials as TopicCromolyn SodiumDrug EvaluationFemaleGuinea PigsHistamine AntagonistsHistamine ReleaseInjections, IntraperitonealMaleMast Cells

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article

Language

eng

PubMed ID

89807

Citation

González, R G., et al. "Comparative Study of Ascorbic Acid and Disodium Cromoglycate in some Models of Experimental Anaphylaxis." Allergologia Et Immunopathologia, vol. 7, no. 3, 1979, pp. 211-6.
González RG, García M, Pérez Saad H, et al. Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis. Allergol Immunopathol (Madr). 1979;7(3):211-6.
González, R. G., García, M., Pérez Saad, H., & de la Vega, A. R. (1979). Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis. Allergologia Et Immunopathologia, 7(3), 211-6.
González RG, et al. Comparative Study of Ascorbic Acid and Disodium Cromoglycate in some Models of Experimental Anaphylaxis. Allergol Immunopathol (Madr). 1979 May-Jun;7(3):211-6. PubMed PMID: 89807.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Comparative study of ascorbic acid and disodium cromoglycate in some models of experimental anaphylaxis. AU - González,R G, AU - García,M, AU - Pérez Saad,H, AU - de la Vega,A R, PY - 1979/5/1/pubmed PY - 1979/5/1/medline PY - 1979/5/1/entrez SP - 211 EP - 6 JF - Allergologia et immunopathologia JO - Allergol Immunopathol (Madr) VL - 7 IS - 3 N2 - The pharmacological activity of vitamin C and the antiallergic drug disodium cromoglycate are compared in models of rat mast cell degranulation and histamine release, and in protracted anaphylactic shock in the guinea pig. Our results demonstrate that ascorbic acid has a very weak inhibitory effect on degranulation and histamine release from mast cells, and therefore cannot be considered a prophylactic antiallergic drug such as disodium cromoglycate. SN - 0301-0546 UR - https://www.unboundmedicine.com/medline/citation/89807/Comparative_study_of_ascorbic_acid_and_disodium_cromoglycate_in_some_models_of_experimental_anaphylaxis_ DB - PRIME DP - Unbound Medicine ER -