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Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment.
J Neurol Sci. 1996 Nov; 143(1-2):64-71.JN

Abstract

Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired in PD than in normal controls, more so in the demented group of patients, and was related to enlargement of third ventricular size in CCT. While intentional memory was age related in PD patients, perception was age-related in normal controls. Neither global nor specific cognitive functions were related to duration, severity of parkinsonian motor disability, or depression. However, depression in PD was significantly related to parkinsonian motor disability. P300 latency was more prolonged in PD patients than normal controls. P300 parameters of PD patients were not influenced by age, cognitive functions, duration or severity of motor disability, or depression. The reaction time was the only P300 parameter that was age-related in normal controls. Subcortical atrophy as indicated by CCT was more marked in PD and correlated with age in both patients and controls. Subcortical atrophy was significantly related to cognitive functions in PD but not in normal controls. It was concluded that cognitive impairment in PD could be attributed to complex cognitive changes rather than age. It is a disease process, though not directly related to parkinsonian motor disability or depression. PD differed from normal aging as regards the effect of age on the specific cognitive functions, where in PD patients, age was related to intentional memory, yet in normal controls, it was related to perception. Intentional memory deterioration was found to be specific of PD, being related to subcortical atrophy as well as being more pronounced in the demented group of patients.

Authors+Show Affiliations

Department of Neurology, Cairo University, Egypt. A_Elwan@frcu.eun.egNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8981300

Citation

Elwan, O H., et al. "Parkinson's Disease, Cognition and Aging. Clinical, Neuropsychological, Electrophysiological and Cranial Computerized Tomographic Assessment." Journal of the Neurological Sciences, vol. 143, no. 1-2, 1996, pp. 64-71.
Elwan OH, Baradah OH, Madkour O, et al. Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment. J Neurol Sci. 1996;143(1-2):64-71.
Elwan, O. H., Baradah, O. H., Madkour, O., Elwan, H., Hassan, A. A., Elwan, F., Mahfouz, M., Ali, A., & Fahmy, M. (1996). Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment. Journal of the Neurological Sciences, 143(1-2), 64-71.
Elwan OH, et al. Parkinson's Disease, Cognition and Aging. Clinical, Neuropsychological, Electrophysiological and Cranial Computerized Tomographic Assessment. J Neurol Sci. 1996;143(1-2):64-71. PubMed PMID: 8981300.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Parkinson's disease, cognition and aging. Clinical, neuropsychological, electrophysiological and cranial computerized tomographic assessment. AU - Elwan,O H, AU - Baradah,O H, AU - Madkour,O, AU - Elwan,H, AU - Hassan,A A, AU - Elwan,F, AU - Mahfouz,M, AU - Ali,A, AU - Fahmy,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 64 EP - 71 JF - Journal of the neurological sciences JO - J. Neurol. Sci. VL - 143 IS - 1-2 N2 - Forty-three patients with Parkinson's disease (PD) and thirty-seven normal volunteers were subjected to clinical, neuropsychological, neurophysiological (P300 component of the event-related potentials ERP) and radiological (cranial computerized tomographic scanning CCT) evaluation. Intentional memory was more impaired in PD than in normal controls, more so in the demented group of patients, and was related to enlargement of third ventricular size in CCT. While intentional memory was age related in PD patients, perception was age-related in normal controls. Neither global nor specific cognitive functions were related to duration, severity of parkinsonian motor disability, or depression. However, depression in PD was significantly related to parkinsonian motor disability. P300 latency was more prolonged in PD patients than normal controls. P300 parameters of PD patients were not influenced by age, cognitive functions, duration or severity of motor disability, or depression. The reaction time was the only P300 parameter that was age-related in normal controls. Subcortical atrophy as indicated by CCT was more marked in PD and correlated with age in both patients and controls. Subcortical atrophy was significantly related to cognitive functions in PD but not in normal controls. It was concluded that cognitive impairment in PD could be attributed to complex cognitive changes rather than age. It is a disease process, though not directly related to parkinsonian motor disability or depression. PD differed from normal aging as regards the effect of age on the specific cognitive functions, where in PD patients, age was related to intentional memory, yet in normal controls, it was related to perception. Intentional memory deterioration was found to be specific of PD, being related to subcortical atrophy as well as being more pronounced in the demented group of patients. SN - 0022-510X UR - https://www.unboundmedicine.com/medline/citation/8981300/Parkinson's_disease_cognition_and_aging__Clinical_neuropsychological_electrophysiological_and_cranial_computerized_tomographic_assessment_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-510X(96)00161-X DB - PRIME DP - Unbound Medicine ER -