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[Calcium, neuronal death and neurological disease].
Rev Neurol. 1996 Oct; 24(134):1199-209.RN

Abstract

Calcium ion (Ca2+) plays a role in several important functions in the central nervous system such as production of action potentials, neurotransmitter release, or neuronal plasticity, etc. However, its excessive influx to neurons due to failure of the mechanisms implicated in the regulation of its intracellular concentration (Ca(2+)-channels, calcium binding proteins), leads to a cascade of events which causes cytotoxicity and neuronal death. Ca2+ mediated toxicity has been implicated in the pathogenesis of neurodegenerative diseases (Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, Huntington's), brain ischemia, epilepsy, cranial trauma, and AIDS-dementia complex. In this article we review the current status of this topic.

Authors+Show Affiliations

Jiménez-Jiménez FJ
Servicio de Neurología Hospital Universitario Príncipe de Asturias, Alcalá de Henares, Madrid, España.
García-Ruiz PJ
No affiliation info available
de Bustos F
No affiliation info available

MeSH

Alzheimer DiseaseAmyotrophic Lateral SclerosisBrainBrain IschemiaCalcium ChannelsCell DeathEpilepsyHumansHuntington DiseaseNerve DegenerationNeuronsParkinson Disease

Pub Type(s)

English Abstract
Journal Article
Research Support, Non-U.S. Gov't
Review

Language

spa

PubMed ID

8983715

Citation

Jiménez-Jiménez, F J., et al. "[Calcium, Neuronal Death and Neurological Disease]." Revista De Neurologia, vol. 24, no. 134, 1996, pp. 1199-209.
Jiménez-Jiménez FJ, García-Ruiz PJ, de Bustos F. [Calcium, neuronal death and neurological disease]. Rev Neurol. 1996;24(134):1199-209.
Jiménez-Jiménez, F. J., García-Ruiz, P. J., & de Bustos, F. (1996). [Calcium, neuronal death and neurological disease]. Revista De Neurologia, 24(134), 1199-209.
Jiménez-Jiménez FJ, García-Ruiz PJ, de Bustos F. [Calcium, Neuronal Death and Neurological Disease]. Rev Neurol. 1996;24(134):1199-209. PubMed PMID: 8983715.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Calcium, neuronal death and neurological disease]. AU - Jiménez-Jiménez,F J, AU - García-Ruiz,P J, AU - de Bustos,F, PY - 1996/10/1/pubmed PY - 1996/10/1/medline PY - 1996/10/1/entrez SP - 1199 EP - 209 JF - Revista de neurologia JO - Rev Neurol VL - 24 IS - 134 N2 - Calcium ion (Ca2+) plays a role in several important functions in the central nervous system such as production of action potentials, neurotransmitter release, or neuronal plasticity, etc. However, its excessive influx to neurons due to failure of the mechanisms implicated in the regulation of its intracellular concentration (Ca(2+)-channels, calcium binding proteins), leads to a cascade of events which causes cytotoxicity and neuronal death. Ca2+ mediated toxicity has been implicated in the pathogenesis of neurodegenerative diseases (Parkinson's, Alzheimer's, amyotrophic lateral sclerosis, Huntington's), brain ischemia, epilepsy, cranial trauma, and AIDS-dementia complex. In this article we review the current status of this topic. SN - 0210-0010 UR - https://www.unboundmedicine.com/medline/citation/8983715/[Calcium_neuronal_death_and_neurological_disease]_ DB - PRIME DP - Unbound Medicine ER -