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[Limbic-hypothalamic-pituitary-adrenal axis in depression: literature review].
Psychiatr Pol. 1996 Sep-Oct; 30(5):741-55.PP

Abstract

A review of the literature has been presented concerning pathogenetic role of limbic-hypothalamic-pituitary-adrenal axis (LHPA) in depression and the therapeutic possibility obtained by influencing this axis. Increased cortisol concentration has until now been the best documented biochemical abnormality in depression. Pathological results of the Dexamethasone Suppression Test pointing to hyperactivity of LHPA axis are found in about half of depressive patients. According to most recent research, primary disturbance of LHPA axis concerns hypothalamus (excessive secretion of corticotropin releasing factory) and limbic system (insufficiency of glucocorticoid receptor). An association was found between disturbances of LHPA axis in depression and immune system abnormalities in this illness. Disturbances of serotonergic and noradrenergic neurotransmission in depression may also partially result from LHPA axis dysfunction. In recent years, the attempts have been made to use drugs acting on LHPA axis for therapeutic purposes in depression, such as ketoconazole, within the framework of antiglucocorticoid strategy. Influencing LHPA axis may underlie the mechanism of new antidepressant drug, tianeptine. Recently, it was found that classical tricyclic antidepressant drugs as well as electroconvulsive may also act on LHPA in regulatory way.

Authors+Show Affiliations

Kliniki Psychiatrii Dorosłych w Poznaniu.No affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

pol

PubMed ID

8984515

Citation

Twardowska, K, and J Rybakowski. "[Limbic-hypothalamic-pituitary-adrenal Axis in Depression: Literature Review]." Psychiatria Polska, vol. 30, no. 5, 1996, pp. 741-55.
Twardowska K, Rybakowski J. [Limbic-hypothalamic-pituitary-adrenal axis in depression: literature review]. Psychiatr Pol. 1996;30(5):741-55.
Twardowska, K., & Rybakowski, J. (1996). [Limbic-hypothalamic-pituitary-adrenal axis in depression: literature review]. Psychiatria Polska, 30(5), 741-55.
Twardowska K, Rybakowski J. [Limbic-hypothalamic-pituitary-adrenal Axis in Depression: Literature Review]. Psychiatr Pol. 1996 Sep-Oct;30(5):741-55. PubMed PMID: 8984515.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Limbic-hypothalamic-pituitary-adrenal axis in depression: literature review]. AU - Twardowska,K, AU - Rybakowski,J, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 741 EP - 55 JF - Psychiatria polska JO - Psychiatr. Pol. VL - 30 IS - 5 N2 - A review of the literature has been presented concerning pathogenetic role of limbic-hypothalamic-pituitary-adrenal axis (LHPA) in depression and the therapeutic possibility obtained by influencing this axis. Increased cortisol concentration has until now been the best documented biochemical abnormality in depression. Pathological results of the Dexamethasone Suppression Test pointing to hyperactivity of LHPA axis are found in about half of depressive patients. According to most recent research, primary disturbance of LHPA axis concerns hypothalamus (excessive secretion of corticotropin releasing factory) and limbic system (insufficiency of glucocorticoid receptor). An association was found between disturbances of LHPA axis in depression and immune system abnormalities in this illness. Disturbances of serotonergic and noradrenergic neurotransmission in depression may also partially result from LHPA axis dysfunction. In recent years, the attempts have been made to use drugs acting on LHPA axis for therapeutic purposes in depression, such as ketoconazole, within the framework of antiglucocorticoid strategy. Influencing LHPA axis may underlie the mechanism of new antidepressant drug, tianeptine. Recently, it was found that classical tricyclic antidepressant drugs as well as electroconvulsive may also act on LHPA in regulatory way. SN - 0033-2674 UR - https://www.unboundmedicine.com/medline/citation/8984515/[Limbic_hypothalamic_pituitary_adrenal_axis_in_depression:_literature_review]_ L2 - http://www.diseaseinfosearch.org/result/2199 DB - PRIME DP - Unbound Medicine ER -