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[Decongestant nasal spray. Results of a rhinomanometric double-blind study].
Schweiz Med Wochenschr 1996; 126(44):1875-80SM

Abstract

Between november 1993 and july 1995 60 patients with a common cold underwent randomized and double-blind testing of 3 commercial nasal sprays-benzydamine, xylometazoline combined with the secretolytic S-carboxymethylcysteine, and phenylephrine combined with the antihistaminic dimethindene maleate. After prior active rhinomanometric measurement of the untreated nose, the test substance was applied. The change of nasal patency was registered after 3 and 10 minutes and then after 2, 4, 6 and 8 hours. At the end the patient gave a subjective evaluation of the used spray. There was no change in nasal obstruction following application of NaCl or benzydamine. Xylometazoline/S-carboxymethylcysteine (+87%) or phenylephrine/ dimethindene maleate (+113%) augmented nasal patency within minutes. Using phenylephrine/dimethindene maleate the effect lasted less than 2 hours, while after xylometazoline/S-carboxymethylcysteine decongestion lasted more than 6 hours. The patients also subjectively reported an increase in nasal patency after the use of benzydamine and placebo. But only phenylephrine/ dimethindene maleate or xylometazoline/S-carboxymethylcysteine were judged good. Using benzydamine or phenylephrine + dimethindene maleate, more side-effects (mainly dryness and burning) were mentioned. Considering the subjective assessment of side-effects and duration of action, as well as objective parameters, derivatives of imidazole (oxymetazoline and xylometazoline) are first choice in treatment of the common cold.

Authors+Show Affiliations

HNO-Klinik, Kantonsspital Aarau.No affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

ger

PubMed ID

8984600

Citation

Maranta, C A., and D Simmen. "[Decongestant Nasal Spray. Results of a Rhinomanometric Double-blind Study]." Schweizerische Medizinische Wochenschrift, vol. 126, no. 44, 1996, pp. 1875-80.
Maranta CA, Simmen D. [Decongestant nasal spray. Results of a rhinomanometric double-blind study]. Schweiz Med Wochenschr. 1996;126(44):1875-80.
Maranta, C. A., & Simmen, D. (1996). [Decongestant nasal spray. Results of a rhinomanometric double-blind study]. Schweizerische Medizinische Wochenschrift, 126(44), pp. 1875-80.
Maranta CA, Simmen D. [Decongestant Nasal Spray. Results of a Rhinomanometric Double-blind Study]. Schweiz Med Wochenschr. 1996 Nov 2;126(44):1875-80. PubMed PMID: 8984600.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Decongestant nasal spray. Results of a rhinomanometric double-blind study]. AU - Maranta,C A, AU - Simmen,D, PY - 1996/11/2/pubmed PY - 1996/11/2/medline PY - 1996/11/2/entrez SP - 1875 EP - 80 JF - Schweizerische medizinische Wochenschrift JO - Schweiz Med Wochenschr VL - 126 IS - 44 N2 - Between november 1993 and july 1995 60 patients with a common cold underwent randomized and double-blind testing of 3 commercial nasal sprays-benzydamine, xylometazoline combined with the secretolytic S-carboxymethylcysteine, and phenylephrine combined with the antihistaminic dimethindene maleate. After prior active rhinomanometric measurement of the untreated nose, the test substance was applied. The change of nasal patency was registered after 3 and 10 minutes and then after 2, 4, 6 and 8 hours. At the end the patient gave a subjective evaluation of the used spray. There was no change in nasal obstruction following application of NaCl or benzydamine. Xylometazoline/S-carboxymethylcysteine (+87%) or phenylephrine/ dimethindene maleate (+113%) augmented nasal patency within minutes. Using phenylephrine/dimethindene maleate the effect lasted less than 2 hours, while after xylometazoline/S-carboxymethylcysteine decongestion lasted more than 6 hours. The patients also subjectively reported an increase in nasal patency after the use of benzydamine and placebo. But only phenylephrine/ dimethindene maleate or xylometazoline/S-carboxymethylcysteine were judged good. Using benzydamine or phenylephrine + dimethindene maleate, more side-effects (mainly dryness and burning) were mentioned. Considering the subjective assessment of side-effects and duration of action, as well as objective parameters, derivatives of imidazole (oxymetazoline and xylometazoline) are first choice in treatment of the common cold. SN - 0036-7672 UR - https://www.unboundmedicine.com/medline/citation/8984600/[Decongestant_nasal_spray__Results_of_a_rhinomanometric_double_blind_study]_ L2 - https://medlineplus.gov/coldandcoughmedicines.html DB - PRIME DP - Unbound Medicine ER -