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5-HT2 receptor involvement in conditioned olfactory learning in the neonate rat pup.
Behav Neurosci. 1996 Dec; 110(6):1426-34.BN

Abstract

These experiments addressed the role of 5-HT2 receptors in conditioned olfactory learning. Ritanserin, a 5-HT2A/2C antagonist, was injected subcutaneously into postnatal day (PND) 7 pups before or after conditioned olfactory training to a peppermint odor. When the pups were tested for olfactory preference on PND 8, those injected with ritanserin before training failed to acquire an odor preference whereas those injected after training learned. This suggested that the 5-HT2 receptor is required only in the acquisition of conditioned olfactory learning. Injection of ritanserin directly into the olfactory bulb before training also blocked preference for the peppermint odor. In pups that had depletion of the 5-HT input to the bulb, subcutaneous injection of a 5-HT2A/2C agonist was sufficient to maintain conditioned olfactory learning, confirming the importance of 5-HT in learning.

Authors+Show Affiliations

Division of Basic Medical Sciences, Memorial University of Newfoundland, St. John's, Canada. mclean@morgan.ucs.mun.caNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8986343

Citation

McLean, J H., et al. "5-HT2 Receptor Involvement in Conditioned Olfactory Learning in the Neonate Rat Pup." Behavioral Neuroscience, vol. 110, no. 6, 1996, pp. 1426-34.
McLean JH, Darby-King A, Hodge E. 5-HT2 receptor involvement in conditioned olfactory learning in the neonate rat pup. Behav Neurosci. 1996;110(6):1426-34.
McLean, J. H., Darby-King, A., & Hodge, E. (1996). 5-HT2 receptor involvement in conditioned olfactory learning in the neonate rat pup. Behavioral Neuroscience, 110(6), 1426-34.
McLean JH, Darby-King A, Hodge E. 5-HT2 Receptor Involvement in Conditioned Olfactory Learning in the Neonate Rat Pup. Behav Neurosci. 1996;110(6):1426-34. PubMed PMID: 8986343.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-HT2 receptor involvement in conditioned olfactory learning in the neonate rat pup. AU - McLean,J H, AU - Darby-King,A, AU - Hodge,E, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 1426 EP - 34 JF - Behavioral neuroscience JO - Behav Neurosci VL - 110 IS - 6 N2 - These experiments addressed the role of 5-HT2 receptors in conditioned olfactory learning. Ritanserin, a 5-HT2A/2C antagonist, was injected subcutaneously into postnatal day (PND) 7 pups before or after conditioned olfactory training to a peppermint odor. When the pups were tested for olfactory preference on PND 8, those injected with ritanserin before training failed to acquire an odor preference whereas those injected after training learned. This suggested that the 5-HT2 receptor is required only in the acquisition of conditioned olfactory learning. Injection of ritanserin directly into the olfactory bulb before training also blocked preference for the peppermint odor. In pups that had depletion of the 5-HT input to the bulb, subcutaneous injection of a 5-HT2A/2C agonist was sufficient to maintain conditioned olfactory learning, confirming the importance of 5-HT in learning. SN - 0735-7044 UR - https://www.unboundmedicine.com/medline/citation/8986343/5_HT2_receptor_involvement_in_conditioned_olfactory_learning_in_the_neonate_rat_pup_ L2 - http://content.apa.org/journals/bne/110/6/1426 DB - PRIME DP - Unbound Medicine ER -