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Inositol prevents folate-resistant neural tube defects in the mouse.
Nat Med. 1997 Jan; 3(1):60-6.NMed

Abstract

Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folic acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to folate. Here, we show that a second vitamin, myo-inositol, is capable of significantly reducing the incidence of spinal NTDs in curly tail mice, a genetic model of folate-resistant NTDs. Inositol increases flux through the inositol/lipid cycle, stimulating protein kinase C activity and upregulating expression of retinoic acid receptor beta, specifically in the caudal portion of the embryonic hindgut. This reduces the delay in closure of the posterior neuropore, the embryonic defect that is known to lead directly to spina bifida in curly tail embryos. Our findings reveal a molecular pathway of NTD prevention and suggest the possible efficacy of combined treatment with folate and inositol in overcoming the majority of human NTDs.

Authors+Show Affiliations

Greene ND
Neural Development Unit, Institute of Child Health, University of London, UK.
Copp AJ
No affiliation info available

MeSH

AnimalsArachidonic AcidEmbryo, MammalianFemaleFolic AcidGene Expression Regulation, DevelopmentalIn Vitro TechniquesInositolMaleMiceMice, Inbred CBAMice, Mutant StrainsNeural Tube DefectsPregnancyProtein Kinase CReceptors, Retinoic AcidTetradecanoylphorbol AcetateUp-Regulation

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

8986742

Citation

Greene, N D., and A J. Copp. "Inositol Prevents Folate-resistant Neural Tube Defects in the Mouse." Nature Medicine, vol. 3, no. 1, 1997, pp. 60-6.
Greene ND, Copp AJ. Inositol prevents folate-resistant neural tube defects in the mouse. Nat Med. 1997;3(1):60-6.
Greene, N. D., & Copp, A. J. (1997). Inositol prevents folate-resistant neural tube defects in the mouse. Nature Medicine, 3(1), 60-6.
Greene ND, Copp AJ. Inositol Prevents Folate-resistant Neural Tube Defects in the Mouse. Nat Med. 1997;3(1):60-6. PubMed PMID: 8986742.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Inositol prevents folate-resistant neural tube defects in the mouse. AU - Greene,N D, AU - Copp,A J, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 60 EP - 6 JF - Nature medicine JO - Nat Med VL - 3 IS - 1 N2 - Clinical trials demonstrate that up to 70% of neural tube defects (NTDs) can be prevented by folic acid supplementation in early pregnancy, whereas the remaining NTDs are resistant to folate. Here, we show that a second vitamin, myo-inositol, is capable of significantly reducing the incidence of spinal NTDs in curly tail mice, a genetic model of folate-resistant NTDs. Inositol increases flux through the inositol/lipid cycle, stimulating protein kinase C activity and upregulating expression of retinoic acid receptor beta, specifically in the caudal portion of the embryonic hindgut. This reduces the delay in closure of the posterior neuropore, the embryonic defect that is known to lead directly to spina bifida in curly tail embryos. Our findings reveal a molecular pathway of NTD prevention and suggest the possible efficacy of combined treatment with folate and inositol in overcoming the majority of human NTDs. SN - 1078-8956 UR - https://www.unboundmedicine.com/medline/citation/8986742/Inositol_prevents_folate_resistant_neural_tube_defects_in_the_mouse_ DB - PRIME DP - Unbound Medicine ER -