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Activity of doramectin against nematode and arthropod parasites of swine.
Vet Parasitol. 1996 Nov 01; 66(1-2):87-94.VP

Abstract

The efficacy of doramectin, a novel avermectin, was assessed against both naturally-acquired and experimentally-induced infections of gastrointestinal roundworms, lungworms, kidneyworms, lice and mites in studies conducted across North America and Europe. Twenty-two studies evaluated efficacy against fourth larval and adult stages of the following nematode species: Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum, Trichuris suis, Metastrongylus spp. and Stephanurus dentatus. Efficacy was evaluated against the louse Haematopinus suis in six studies and against the mite Sarcoptes scabiei in four studies. A common study design was employed for each study type. In all studies, animals were allotted at random to a doramectin-treated or a saline-treated group. The doramectin-treated group received the drug at 300 micrograms kg-1 by intramuscular injection while the saline-treated group received saline by the same route. In the nematode studies, worm burdens were determined for each animal at slaughter 14-16 days after treatment. Efficacy against each nematode species/stage was assessed on the basis of percentage reduction in geometric mean worm burden in doramectin-treated animals compared with saline-treated controls. In louse and mite studies, counts were made immediately before treatment and then at weekly intervals for four weeks. Efficacy was based on a comparison of the level of infestation on the day of treatment with that on the last day of test. Data from individual studies were combined to derive a single estimate of efficacy against each of the parasite species represented in the study program. Efficacy of doramectin was 98% or greater against all nematode species except T. suis for which the efficacy was 87% and 79% against adult and fourth larval stage, respectively. Efficacy was 100% against both Haematopinus suis and Sarcoptes scabiei.

Authors+Show Affiliations

Pfizer Central Research, Groton, CT, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8988559

Citation

Logan, N B., et al. "Activity of Doramectin Against Nematode and Arthropod Parasites of Swine." Veterinary Parasitology, vol. 66, no. 1-2, 1996, pp. 87-94.
Logan NB, Weatherley AJ, Jones RM. Activity of doramectin against nematode and arthropod parasites of swine. Vet Parasitol. 1996;66(1-2):87-94.
Logan, N. B., Weatherley, A. J., & Jones, R. M. (1996). Activity of doramectin against nematode and arthropod parasites of swine. Veterinary Parasitology, 66(1-2), 87-94.
Logan NB, Weatherley AJ, Jones RM. Activity of Doramectin Against Nematode and Arthropod Parasites of Swine. Vet Parasitol. 1996 Nov 1;66(1-2):87-94. PubMed PMID: 8988559.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Activity of doramectin against nematode and arthropod parasites of swine. AU - Logan,N B, AU - Weatherley,A J, AU - Jones,R M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 87 EP - 94 JF - Veterinary parasitology JO - Vet. Parasitol. VL - 66 IS - 1-2 N2 - The efficacy of doramectin, a novel avermectin, was assessed against both naturally-acquired and experimentally-induced infections of gastrointestinal roundworms, lungworms, kidneyworms, lice and mites in studies conducted across North America and Europe. Twenty-two studies evaluated efficacy against fourth larval and adult stages of the following nematode species: Hyostrongylus rubidus, Ascaris suum, Strongyloides ransomi, Oesophagostomum dentatum, Oesophagostomum quadrispinulatum, Trichuris suis, Metastrongylus spp. and Stephanurus dentatus. Efficacy was evaluated against the louse Haematopinus suis in six studies and against the mite Sarcoptes scabiei in four studies. A common study design was employed for each study type. In all studies, animals were allotted at random to a doramectin-treated or a saline-treated group. The doramectin-treated group received the drug at 300 micrograms kg-1 by intramuscular injection while the saline-treated group received saline by the same route. In the nematode studies, worm burdens were determined for each animal at slaughter 14-16 days after treatment. Efficacy against each nematode species/stage was assessed on the basis of percentage reduction in geometric mean worm burden in doramectin-treated animals compared with saline-treated controls. In louse and mite studies, counts were made immediately before treatment and then at weekly intervals for four weeks. Efficacy was based on a comparison of the level of infestation on the day of treatment with that on the last day of test. Data from individual studies were combined to derive a single estimate of efficacy against each of the parasite species represented in the study program. Efficacy of doramectin was 98% or greater against all nematode species except T. suis for which the efficacy was 87% and 79% against adult and fourth larval stage, respectively. Efficacy was 100% against both Haematopinus suis and Sarcoptes scabiei. SN - 0304-4017 UR - https://www.unboundmedicine.com/medline/citation/8988559/Activity_of_doramectin_against_nematode_and_arthropod_parasites_of_swine_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0304-4017(96)00999-5 DB - PRIME DP - Unbound Medicine ER -