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The application of quantitative risk assessment to microbial food safety risks.
Crit Rev Microbiol. 1996; 22(4):279-93.CR

Abstract

Regulatory programs and guidelines for the control of foodborne microbial agents have existed in the U.S. for nearly 100 years. However, increased awareness of the scope and magnitude of foodborne disease, as well as the emergence of previously unrecognized human pathogens transmitted via the foodborne route, have prompted regulatory officials to consider new and improved strategies to reduce the health risks associated with pathogenic microorganisms in foods. Implementation of these proposed strategies will involve definitive costs for a finite level of risk reduction. While regulatory decisions regarding the management of foodborne disease risk have traditionally been done with the aid of the scientific community, a formal conceptual framework for the evaluation of health risks from pathogenic microorganisms in foods is warranted. Quantitative risk assessment (QRA), which is formally defined as the technical assessment of the nature and magnitude of a risk caused by a hazard, provides such a framework. Reproducing microorganisms in foods present a particular challenge to QRA because both their introduction and numbers may be affected by numerous factors within the food chain, with all of these factors representing significant stages in food production, handling, and consumption, in a farm-to-table type of approach. The process of QRA entails four designated phases: (1) hazard identification, (2) exposure assessment, (3) dose-response assessment, and (4) risk characterization. Specific analytical tools are available to accomplish the analyses required for each phase of the QRA. The purpose of this paper is to provide a description of the conceptual framework for quantitative microbial risk assessment within the standard description provided by the National Academy of Sciences (NAS) paradigm. Each of the sequential steps in QRA are discussed in detail, providing information on current applications, tools for conducting the analyses, and methodological and/or data limitations to date. Conclusions include a brief discussion of subsequent uncertainty and risk analysis methodologies, and a commentary on present and future applications of QRA in the management of the public health risks associated with the presence of pathogenic microorganisms in the food supply.

Authors+Show Affiliations

Department of Food Science, North Carolina State University, Raleigh 27695-7624, USA.

Pub Type(s)

Journal Article
Review

Language

eng

PubMed ID

8989514

Citation

Jaykus, L A.. "The Application of Quantitative Risk Assessment to Microbial Food Safety Risks." Critical Reviews in Microbiology, vol. 22, no. 4, 1996, pp. 279-93.
Jaykus LA. The application of quantitative risk assessment to microbial food safety risks. Crit Rev Microbiol. 1996;22(4):279-93.
Jaykus, L. A. (1996). The application of quantitative risk assessment to microbial food safety risks. Critical Reviews in Microbiology, 22(4), 279-93.
Jaykus LA. The Application of Quantitative Risk Assessment to Microbial Food Safety Risks. Crit Rev Microbiol. 1996;22(4):279-93. PubMed PMID: 8989514.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The application of quantitative risk assessment to microbial food safety risks. A1 - Jaykus,L A, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 279 EP - 93 JF - Critical reviews in microbiology JO - Crit Rev Microbiol VL - 22 IS - 4 N2 - Regulatory programs and guidelines for the control of foodborne microbial agents have existed in the U.S. for nearly 100 years. However, increased awareness of the scope and magnitude of foodborne disease, as well as the emergence of previously unrecognized human pathogens transmitted via the foodborne route, have prompted regulatory officials to consider new and improved strategies to reduce the health risks associated with pathogenic microorganisms in foods. Implementation of these proposed strategies will involve definitive costs for a finite level of risk reduction. While regulatory decisions regarding the management of foodborne disease risk have traditionally been done with the aid of the scientific community, a formal conceptual framework for the evaluation of health risks from pathogenic microorganisms in foods is warranted. Quantitative risk assessment (QRA), which is formally defined as the technical assessment of the nature and magnitude of a risk caused by a hazard, provides such a framework. Reproducing microorganisms in foods present a particular challenge to QRA because both their introduction and numbers may be affected by numerous factors within the food chain, with all of these factors representing significant stages in food production, handling, and consumption, in a farm-to-table type of approach. The process of QRA entails four designated phases: (1) hazard identification, (2) exposure assessment, (3) dose-response assessment, and (4) risk characterization. Specific analytical tools are available to accomplish the analyses required for each phase of the QRA. The purpose of this paper is to provide a description of the conceptual framework for quantitative microbial risk assessment within the standard description provided by the National Academy of Sciences (NAS) paradigm. Each of the sequential steps in QRA are discussed in detail, providing information on current applications, tools for conducting the analyses, and methodological and/or data limitations to date. Conclusions include a brief discussion of subsequent uncertainty and risk analysis methodologies, and a commentary on present and future applications of QRA in the management of the public health risks associated with the presence of pathogenic microorganisms in the food supply. SN - 1040-841X UR - https://www.unboundmedicine.com/medline/citation/8989514/The_application_of_quantitative_risk_assessment_to_microbial_food_safety_risks_ L2 - https://www.tandfonline.com/doi/full/10.3109/10408419609105483 DB - PRIME DP - Unbound Medicine ER -