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Cytologic features of ductal carcinoma in situ.
Diagn Cytopathol. 1996 Dec; 15(5):367-73.DC

Abstract

Fourteen cases of both palpable and non-palpable breast lesions reported as possible ductal carcinoma in situ (DCIS) on fine-needle biopsy (FNB) over a 12-mo period were retrieved from our files and compared to the subsequent histologic diagnosis. Although a definite cytologic pattern of highly cellular smears with high grade nuclei, dissociation, and background necrosis with microcalcifications emerged for comedo DCIS, it was not possible to differentiate these on cytologic grounds from high grade infiltrating carcinoma with necrosis unless mammographic findings were taken into account. Useful criteria for non-comedo low grade DCIS were high cellularity, low grade nuclei, and architectural features of papillary and three dimensional (3D) fragments, palisade arrangements, and monolayer sheets with punched out glandular lumina. We conclude that FNB has a definite role in the diagnosis of these lesions, with the limitation that invasive malignancy can never be excluded on cytologic criteria alone and clinico-radiological correlation is paramount.

Authors+Show Affiliations

Department of Hampson Pathology, Westmead, NSW, Australia.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8989536

Citation

Theocharous, C, and M L. Greenberg. "Cytologic Features of Ductal Carcinoma in Situ." Diagnostic Cytopathology, vol. 15, no. 5, 1996, pp. 367-73.
Theocharous C, Greenberg ML. Cytologic features of ductal carcinoma in situ. Diagn Cytopathol. 1996;15(5):367-73.
Theocharous, C., & Greenberg, M. L. (1996). Cytologic features of ductal carcinoma in situ. Diagnostic Cytopathology, 15(5), 367-73.
Theocharous C, Greenberg ML. Cytologic Features of Ductal Carcinoma in Situ. Diagn Cytopathol. 1996;15(5):367-73. PubMed PMID: 8989536.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Cytologic features of ductal carcinoma in situ. AU - Theocharous,C, AU - Greenberg,M L, PY - 1996/12/1/pubmed PY - 2000/6/22/medline PY - 1996/12/1/entrez SP - 367 EP - 73 JF - Diagnostic cytopathology JO - Diagn Cytopathol VL - 15 IS - 5 N2 - Fourteen cases of both palpable and non-palpable breast lesions reported as possible ductal carcinoma in situ (DCIS) on fine-needle biopsy (FNB) over a 12-mo period were retrieved from our files and compared to the subsequent histologic diagnosis. Although a definite cytologic pattern of highly cellular smears with high grade nuclei, dissociation, and background necrosis with microcalcifications emerged for comedo DCIS, it was not possible to differentiate these on cytologic grounds from high grade infiltrating carcinoma with necrosis unless mammographic findings were taken into account. Useful criteria for non-comedo low grade DCIS were high cellularity, low grade nuclei, and architectural features of papillary and three dimensional (3D) fragments, palisade arrangements, and monolayer sheets with punched out glandular lumina. We conclude that FNB has a definite role in the diagnosis of these lesions, with the limitation that invasive malignancy can never be excluded on cytologic criteria alone and clinico-radiological correlation is paramount. SN - 8755-1039 UR - https://www.unboundmedicine.com/medline/citation/8989536/Cytologic_features_of_ductal_carcinoma_in_situ_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=8755-1039&date=1996&volume=15&issue=5&spage=367 DB - PRIME DP - Unbound Medicine ER -