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Platelet function in patients with sickle cell anaemia in Nairobi.
East Afr Med J. 1996 Sep; 73(9):568-70.EA

Abstract

From July 1990 to January 1991 we studied platelet functions in 55 indigenous Kenyan patients (23 males and 32 females) with sickle cell anaemia (SCA) in steady state (SCASS) and in 20 (11 males and 9 females) SCA patients in vaso-occlusive sickle cell crisis (VSCC). A control group of 50 healthy (23 males and 27 females) individuals matched for age and sex was also studied. Platelet aggregation time to ADP in SCASS (57.2 +/- 39.1) and in VSCC (31 +/- 11.1) were more prolonged (p < 0.05) compared to controls (12.7 +/- 5.2). It was also significantly more prolonged (p < 0.05) in VSCC than in SCASS. Platelet adhesiveness time was 31.1 +/- 13.7 seconds in SCASS, 30.9 +/- 11.1 in VSCC, and 37.7 +/- 13.0 in controls and was significantly lower in both SCA groups (p < 0.05) but there was no significant difference between the two SCA groups themselves. Clot retraction was 52.8 +/- 6.9 in SCASS, 53.6 +/- 10.7 in VSCC, and 45.9 +/- 8 in controls and was significantly higher in both SCA groups than in controls (p < 0.05). There was no significant difference between the two SCA groups themselves. We conclude that platelet function is deranged in indigenous Kenyan patients with SCA.

Authors+Show Affiliations

Division of Medicine, Kenyatta National Hospital, Nairobi, Kenya.No affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

8991234

Citation

Maina, J M., and J R. Aluoch. "Platelet Function in Patients With Sickle Cell Anaemia in Nairobi." East African Medical Journal, vol. 73, no. 9, 1996, pp. 568-70.
Maina JM, Aluoch JR. Platelet function in patients with sickle cell anaemia in Nairobi. East Afr Med J. 1996;73(9):568-70.
Maina, J. M., & Aluoch, J. R. (1996). Platelet function in patients with sickle cell anaemia in Nairobi. East African Medical Journal, 73(9), 568-70.
Maina JM, Aluoch JR. Platelet Function in Patients With Sickle Cell Anaemia in Nairobi. East Afr Med J. 1996;73(9):568-70. PubMed PMID: 8991234.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Platelet function in patients with sickle cell anaemia in Nairobi. AU - Maina,J M, AU - Aluoch,J R, PY - 1996/9/1/pubmed PY - 1996/9/1/medline PY - 1996/9/1/entrez SP - 568 EP - 70 JF - East African medical journal JO - East Afr Med J VL - 73 IS - 9 N2 - From July 1990 to January 1991 we studied platelet functions in 55 indigenous Kenyan patients (23 males and 32 females) with sickle cell anaemia (SCA) in steady state (SCASS) and in 20 (11 males and 9 females) SCA patients in vaso-occlusive sickle cell crisis (VSCC). A control group of 50 healthy (23 males and 27 females) individuals matched for age and sex was also studied. Platelet aggregation time to ADP in SCASS (57.2 +/- 39.1) and in VSCC (31 +/- 11.1) were more prolonged (p < 0.05) compared to controls (12.7 +/- 5.2). It was also significantly more prolonged (p < 0.05) in VSCC than in SCASS. Platelet adhesiveness time was 31.1 +/- 13.7 seconds in SCASS, 30.9 +/- 11.1 in VSCC, and 37.7 +/- 13.0 in controls and was significantly lower in both SCA groups (p < 0.05) but there was no significant difference between the two SCA groups themselves. Clot retraction was 52.8 +/- 6.9 in SCASS, 53.6 +/- 10.7 in VSCC, and 45.9 +/- 8 in controls and was significantly higher in both SCA groups than in controls (p < 0.05). There was no significant difference between the two SCA groups themselves. We conclude that platelet function is deranged in indigenous Kenyan patients with SCA. SN - 0012-835X UR - https://www.unboundmedicine.com/medline/citation/8991234/Platelet_function_in_patients_with_sickle_cell_anaemia_in_Nairobi_ DB - PRIME DP - Unbound Medicine ER -