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Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease.
Gut 1996; 39(2):180-4Gut

Abstract

BACKGROUND/AIMS

Calcium and vitamin D malabsorption in coeliac disease predispose to skeletal demineralisation. This study aimed to determine bone mineral density in patients studied in the first year after diagnosis of coeliac disease, and to detect changes in bone mineral density over the subsequent year.

METHODS

Lumbar spine and femoral neck bone mineral density was measured in 21 adults with coeliac disease, diagnosed and started on a gluten free diet during the preceding year, with dual energy x ray absorptiometry and repeated after 12 months.

RESULTS

Bone mineral density was significantly lower in patients than in paired controls (matched for age and sex), at lumbar spine (0.819 g/cm2 compared with 1.021 g/cm2, p < 0.001 Wilcoxon signed rank test) and femoral neck (0.663 g/cm2 compared with 0.794 g/cm2, p < 0.001). Repeat measurement after 12 months demonstrated that patients had a significant gain in bone mineral density at lumbar spine (16.6%/year), and femoral neck (15.5%/year, p < 0.002, Wilcoxon signed rank test at both sites), whereas no significant change in bone mineral density was detected in controls.

CONCLUSIONS

Treatment of coeliac disease with a gluten free diet is associated with a significant increase in bone mineral density, although patients still had lower bone mineral density than controls.

Authors+Show Affiliations

Department of Gastroenterology, and Wolfson Centre Clinical Research Unit, Royal United Hospital, Bath.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8991855

Citation

McFarlane, X A., et al. "Effect of a Gluten Free Diet On Osteopenia in Adults With Newly Diagnosed Coeliac Disease." Gut, vol. 39, no. 2, 1996, pp. 180-4.
McFarlane XA, Bhalla AK, Robertson DA. Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease. Gut. 1996;39(2):180-4.
McFarlane, X. A., Bhalla, A. K., & Robertson, D. A. (1996). Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease. Gut, 39(2), pp. 180-4.
McFarlane XA, Bhalla AK, Robertson DA. Effect of a Gluten Free Diet On Osteopenia in Adults With Newly Diagnosed Coeliac Disease. Gut. 1996;39(2):180-4. PubMed PMID: 8991855.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of a gluten free diet on osteopenia in adults with newly diagnosed coeliac disease. AU - McFarlane,X A, AU - Bhalla,A K, AU - Robertson,D A, PY - 1996/8/1/pubmed PY - 1996/8/1/medline PY - 1996/8/1/entrez SP - 180 EP - 4 JF - Gut JO - Gut VL - 39 IS - 2 N2 - BACKGROUND/AIMS: Calcium and vitamin D malabsorption in coeliac disease predispose to skeletal demineralisation. This study aimed to determine bone mineral density in patients studied in the first year after diagnosis of coeliac disease, and to detect changes in bone mineral density over the subsequent year. METHODS: Lumbar spine and femoral neck bone mineral density was measured in 21 adults with coeliac disease, diagnosed and started on a gluten free diet during the preceding year, with dual energy x ray absorptiometry and repeated after 12 months. RESULTS: Bone mineral density was significantly lower in patients than in paired controls (matched for age and sex), at lumbar spine (0.819 g/cm2 compared with 1.021 g/cm2, p < 0.001 Wilcoxon signed rank test) and femoral neck (0.663 g/cm2 compared with 0.794 g/cm2, p < 0.001). Repeat measurement after 12 months demonstrated that patients had a significant gain in bone mineral density at lumbar spine (16.6%/year), and femoral neck (15.5%/year, p < 0.002, Wilcoxon signed rank test at both sites), whereas no significant change in bone mineral density was detected in controls. CONCLUSIONS: Treatment of coeliac disease with a gluten free diet is associated with a significant increase in bone mineral density, although patients still had lower bone mineral density than controls. SN - 0017-5749 UR - https://www.unboundmedicine.com/medline/citation/8991855/Effect_of_a_gluten_free_diet_on_osteopenia_in_adults_with_newly_diagnosed_coeliac_disease_ L2 - http://gut.bmj.com/cgi/pmidlookup?view=long&amp;pmid=8991855 DB - PRIME DP - Unbound Medicine ER -