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[The combination of oral lysine-acetylsalicylate and metoclopramide compared with oral sumatriptan in the treatment of migraine attacks. A randomized, double-blind, placebo-controlled clinical trial].
Ugeskr Laeger. 1996 Nov 04; 158(45):6435-9.UL

Abstract

A combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS + MTC) was compared with oral sumatriptan (100 mg) and placebo in 421 patients with migraine in a randomized, double-blind, clinical trial. LAS + MTC was as effective as sumatriptan with a decrease in headache from severe or moderate to mild or none in 57% and 53%, respectively, for the first migraine attack treated, the primary efficacy parameter. Both treatments were better than placebo (success rate 24%, p < 0.001). LAS + MTC was better tolerated than sumatriptan (adverse events in 18% and 28%, respectively, p < 0.05).

Authors+Show Affiliations

Neurologisk afdeling, Bispebjerg Hospital, København.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
English Abstract
Journal Article
Randomized Controlled Trial

Language

dan

PubMed ID

8992678

Citation

Tfelt-Hansen, P, et al. "[The Combination of Oral Lysine-acetylsalicylate and Metoclopramide Compared With Oral Sumatriptan in the Treatment of Migraine Attacks. a Randomized, Double-blind, Placebo-controlled Clinical Trial]." Ugeskrift for Laeger, vol. 158, no. 45, 1996, pp. 6435-9.
Tfelt-Hansen P, Henry P, Mulder LJ, et al. [The combination of oral lysine-acetylsalicylate and metoclopramide compared with oral sumatriptan in the treatment of migraine attacks. A randomized, double-blind, placebo-controlled clinical trial]. Ugeskr Laeger. 1996;158(45):6435-9.
Tfelt-Hansen, P., Henry, P., Mulder, L. J., Scheldewaert, R. G., Schoenen, J., & Chazot, G. (1996). [The combination of oral lysine-acetylsalicylate and metoclopramide compared with oral sumatriptan in the treatment of migraine attacks. A randomized, double-blind, placebo-controlled clinical trial]. Ugeskrift for Laeger, 158(45), 6435-9.
Tfelt-Hansen P, et al. [The Combination of Oral Lysine-acetylsalicylate and Metoclopramide Compared With Oral Sumatriptan in the Treatment of Migraine Attacks. a Randomized, Double-blind, Placebo-controlled Clinical Trial]. Ugeskr Laeger. 1996 Nov 4;158(45):6435-9. PubMed PMID: 8992678.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [The combination of oral lysine-acetylsalicylate and metoclopramide compared with oral sumatriptan in the treatment of migraine attacks. A randomized, double-blind, placebo-controlled clinical trial]. AU - Tfelt-Hansen,P, AU - Henry,P, AU - Mulder,L J, AU - Scheldewaert,R G, AU - Schoenen,J, AU - Chazot,G, PY - 1996/11/4/pubmed PY - 1996/11/4/medline PY - 1996/11/4/entrez SP - 6435 EP - 9 JF - Ugeskrift for laeger JO - Ugeskr Laeger VL - 158 IS - 45 N2 - A combination of lysine acetylsalicylate (equivalent to 900 mg aspirin) and 10 mg metoclopramide (LAS + MTC) was compared with oral sumatriptan (100 mg) and placebo in 421 patients with migraine in a randomized, double-blind, clinical trial. LAS + MTC was as effective as sumatriptan with a decrease in headache from severe or moderate to mild or none in 57% and 53%, respectively, for the first migraine attack treated, the primary efficacy parameter. Both treatments were better than placebo (success rate 24%, p < 0.001). LAS + MTC was better tolerated than sumatriptan (adverse events in 18% and 28%, respectively, p < 0.05). SN - 0041-5782 UR - https://www.unboundmedicine.com/medline/citation/8992678/[The_combination_of_oral_lysine_acetylsalicylate_and_metoclopramide_compared_with_oral_sumatriptan_in_the_treatment_of_migraine_attacks__A_randomized_double_blind_placebo_controlled_clinical_trial]_ L2 - http://www.diseaseinfosearch.org/result/4811 DB - PRIME DP - Unbound Medicine ER -