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Yersinia pestis--etiologic agent of plague.
Clin Microbiol Rev. 1997 Jan; 10(1):35-66.CM

Abstract

Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to the wide range of mammalian hosts and their attendant fleas. The flea/rodent life cycle of Y. pestis, a gram-negative obligate pathogen, exposes it to very different environmental conditions and has resulted in some novel traits facilitating transmission and infection. Studies characterizing virulence determinants of Y. pestis have identified novel mechanisms for overcoming host defenses. Regulatory systems controlling the expression of some of these virulence factors have proven quite complex. These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague.

Authors+Show Affiliations

Department of Microbiology and Immunology, University of Kentucky, Lexington 40536, USA. rperry@pop.uky.eduNo affiliation info available

Pub Type(s)

Historical Article
Journal Article
Research Support, U.S. Gov't, P.H.S.
Review

Language

eng

PubMed ID

8993858

Citation

Perry, R D., and J D. Fetherston. "Yersinia Pestis--etiologic Agent of Plague." Clinical Microbiology Reviews, vol. 10, no. 1, 1997, pp. 35-66.
Perry RD, Fetherston JD. Yersinia pestis--etiologic agent of plague. Clin Microbiol Rev. 1997;10(1):35-66.
Perry, R. D., & Fetherston, J. D. (1997). Yersinia pestis--etiologic agent of plague. Clinical Microbiology Reviews, 10(1), 35-66.
Perry RD, Fetherston JD. Yersinia Pestis--etiologic Agent of Plague. Clin Microbiol Rev. 1997;10(1):35-66. PubMed PMID: 8993858.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Yersinia pestis--etiologic agent of plague. AU - Perry,R D, AU - Fetherston,J D, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 35 EP - 66 JF - Clinical microbiology reviews JO - Clin. Microbiol. Rev. VL - 10 IS - 1 N2 - Plague is a widespread zoonotic disease that is caused by Yersinia pestis and has had devastating effects on the human population throughout history. Disappearance of the disease is unlikely due to the wide range of mammalian hosts and their attendant fleas. The flea/rodent life cycle of Y. pestis, a gram-negative obligate pathogen, exposes it to very different environmental conditions and has resulted in some novel traits facilitating transmission and infection. Studies characterizing virulence determinants of Y. pestis have identified novel mechanisms for overcoming host defenses. Regulatory systems controlling the expression of some of these virulence factors have proven quite complex. These areas of research have provide new insights into the host-parasite relationship. This review will update our present understanding of the history, etiology, epidemiology, clinical aspects, and public health issues of plague. SN - 0893-8512 UR - https://www.unboundmedicine.com/medline/citation/8993858/full_citation L2 - http://cmr.asm.org/cgi/pmidlookup?view=long&pmid=8993858 DB - PRIME DP - Unbound Medicine ER -