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Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grower and finisher swine.
J Anim Sci. 1996 Dec; 74(12):2967-74.JA

Abstract

Three experiments conducted with grower-finisher pigs evaluated sodium selenite and a Se-enriched yeast source at various dietary Se levels on Se retention, tissue and serum Se concentrations, and serum glutathione peroxidase (GSH-Px) activity. Experiment 1 was a balance trial conducted in a 2 x 3 factorial arrangement in a randomized complete block (RCB) design in six replicates. Both Se sources were added at .1, .3, or .5 ppm Se. Crossbred barrows (n = 36) averaging 35.9 kg BW were placed in individual metabolism crates and fed their treatment diets, with feces and urine collected for a 7-d test period. Selenium retention increased as dietary Se levels increased, particularly when the Se-enriched yeast was provided, resulting in a Se source x Se level interaction (P < .01). As dietary Se levels increased, urinary Se increased more when pigs were fed sodium selenite, whereas fecal Se increased more when the Se-enriched yeast was fed; both excretion routes resulting in Se level x Se source interaction responses (P < .01). Experiments 2 and 3 were conducted as RCB involving grower (n = 210) and finisher (n = 266) pigs, respectively, and evaluated the two Se sources each at .1, .3, or .5 ppm Se with a non-Se-fortified basal diet serving as a negative control. In Exp. 2, pigs were fed their treatment diets from 22.2 to 60 kg BW in five replicates, whereas in Exp. 3 diets were fed from 65.8 to 105 kg BW in six replicates. Grower pigs fed sodium selenite had serum GSH-Px activity that reached a plateau at .1 ppm Se and .3 ppm when the Se-enriched yeast source was fed, but the interaction response was not significant (P < .15). During the finisher period, serum GSH-Px activity reached a plateau at .1 ppm Se for both Se sources. Serum Se concentrations were lower at .1 ppm Se when the Se-enriched yeast source was fed, resulting in a source x level interaction response for both grower (P < .05) and finisher (P < .01) periods. Loin Se contents were higher in grower and finisher pigs as dietary Se levels increased when the Se-enriched yeast was fed, resulting in a Se source x Se level interaction (P < .01). The results suggest that more Se was retained in muscle tissue when the Se-enriched yeast source was fed, that serum GSH-Px activity reached a plateau at approximately .1 ppm Se, and that sodium selenite may be more biologically available for GSH-Px activity than the Se-enriched yeast source.

Authors+Show Affiliations

Department of Animal Sciences, Ohio State University, Columbus, USA.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't
Research Support, U.S. Gov't, Non-P.H.S.

Language

eng

PubMed ID

8994911

Citation

Mahan, D C., and N A. Parrett. "Evaluating the Efficacy of Selenium-enriched Yeast and Sodium Selenite On Tissue Selenium Retention and Serum Glutathione Peroxidase Activity in Grower and Finisher Swine." Journal of Animal Science, vol. 74, no. 12, 1996, pp. 2967-74.
Mahan DC, Parrett NA. Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grower and finisher swine. J Anim Sci. 1996;74(12):2967-74.
Mahan, D. C., & Parrett, N. A. (1996). Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grower and finisher swine. Journal of Animal Science, 74(12), 2967-74.
Mahan DC, Parrett NA. Evaluating the Efficacy of Selenium-enriched Yeast and Sodium Selenite On Tissue Selenium Retention and Serum Glutathione Peroxidase Activity in Grower and Finisher Swine. J Anim Sci. 1996;74(12):2967-74. PubMed PMID: 8994911.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Evaluating the efficacy of selenium-enriched yeast and sodium selenite on tissue selenium retention and serum glutathione peroxidase activity in grower and finisher swine. AU - Mahan,D C, AU - Parrett,N A, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 2967 EP - 74 JF - Journal of animal science JO - J Anim Sci VL - 74 IS - 12 N2 - Three experiments conducted with grower-finisher pigs evaluated sodium selenite and a Se-enriched yeast source at various dietary Se levels on Se retention, tissue and serum Se concentrations, and serum glutathione peroxidase (GSH-Px) activity. Experiment 1 was a balance trial conducted in a 2 x 3 factorial arrangement in a randomized complete block (RCB) design in six replicates. Both Se sources were added at .1, .3, or .5 ppm Se. Crossbred barrows (n = 36) averaging 35.9 kg BW were placed in individual metabolism crates and fed their treatment diets, with feces and urine collected for a 7-d test period. Selenium retention increased as dietary Se levels increased, particularly when the Se-enriched yeast was provided, resulting in a Se source x Se level interaction (P < .01). As dietary Se levels increased, urinary Se increased more when pigs were fed sodium selenite, whereas fecal Se increased more when the Se-enriched yeast was fed; both excretion routes resulting in Se level x Se source interaction responses (P < .01). Experiments 2 and 3 were conducted as RCB involving grower (n = 210) and finisher (n = 266) pigs, respectively, and evaluated the two Se sources each at .1, .3, or .5 ppm Se with a non-Se-fortified basal diet serving as a negative control. In Exp. 2, pigs were fed their treatment diets from 22.2 to 60 kg BW in five replicates, whereas in Exp. 3 diets were fed from 65.8 to 105 kg BW in six replicates. Grower pigs fed sodium selenite had serum GSH-Px activity that reached a plateau at .1 ppm Se and .3 ppm when the Se-enriched yeast source was fed, but the interaction response was not significant (P < .15). During the finisher period, serum GSH-Px activity reached a plateau at .1 ppm Se for both Se sources. Serum Se concentrations were lower at .1 ppm Se when the Se-enriched yeast source was fed, resulting in a source x level interaction response for both grower (P < .05) and finisher (P < .01) periods. Loin Se contents were higher in grower and finisher pigs as dietary Se levels increased when the Se-enriched yeast was fed, resulting in a Se source x Se level interaction (P < .01). The results suggest that more Se was retained in muscle tissue when the Se-enriched yeast source was fed, that serum GSH-Px activity reached a plateau at approximately .1 ppm Se, and that sodium selenite may be more biologically available for GSH-Px activity than the Se-enriched yeast source. SN - 0021-8812 UR - https://www.unboundmedicine.com/medline/citation/8994911/Evaluating_the_efficacy_of_selenium_enriched_yeast_and_sodium_selenite_on_tissue_selenium_retention_and_serum_glutathione_peroxidase_activity_in_grower_and_finisher_swine_ L2 - https://academic.oup.com/jas/article-lookup/doi/10.2527/1996.74122967x DB - PRIME DP - Unbound Medicine ER -