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Microvascular changes in venous disease: an update.
Angiology. 1997 Jan; 48(1):27-32.A

Abstract

In an overview the microvascular involvement in chronic venous insufficiency (CVI) is described. Microangiopathy in the lower leg areas is characterized by the presence of typical enlarged and ramified blood capillaries, reduced capillary number, microvascular thrombosis and obliterations, and/or increased permeability of microlymphatics. Transcutaneous oxygen tension (tcPO2) is decreased and directly correlated to the number of perfused capillaries, whereas laser Doppler flux is enhanced. This apparent paradox may be explained by hyperperfusion in the deeper skin layers (mainly shunt vessels) and hypoperfusion in the superficial nutritive vessels. Microvascular changes are of patchy distribution. Trophic changes up to overt venous ulceration are mainly caused by microvascular ischemia and edema formation due to increased capillary permeability and deficient lymphatic drainage.

Authors+Show Affiliations

Department of Medicine, University Hospital, Zurich, Switzerland.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8995340

Citation

Bollinger, A, et al. "Microvascular Changes in Venous Disease: an Update." Angiology, vol. 48, no. 1, 1997, pp. 27-32.
Bollinger A, Leu AJ, Hoffmann U, et al. Microvascular changes in venous disease: an update. Angiology. 1997;48(1):27-32.
Bollinger, A., Leu, A. J., Hoffmann, U., & Franzeck, U. K. (1997). Microvascular changes in venous disease: an update. Angiology, 48(1), 27-32.
Bollinger A, et al. Microvascular Changes in Venous Disease: an Update. Angiology. 1997;48(1):27-32. PubMed PMID: 8995340.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Microvascular changes in venous disease: an update. AU - Bollinger,A, AU - Leu,A J, AU - Hoffmann,U, AU - Franzeck,U K, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 27 EP - 32 JF - Angiology JO - Angiology VL - 48 IS - 1 N2 - In an overview the microvascular involvement in chronic venous insufficiency (CVI) is described. Microangiopathy in the lower leg areas is characterized by the presence of typical enlarged and ramified blood capillaries, reduced capillary number, microvascular thrombosis and obliterations, and/or increased permeability of microlymphatics. Transcutaneous oxygen tension (tcPO2) is decreased and directly correlated to the number of perfused capillaries, whereas laser Doppler flux is enhanced. This apparent paradox may be explained by hyperperfusion in the deeper skin layers (mainly shunt vessels) and hypoperfusion in the superficial nutritive vessels. Microvascular changes are of patchy distribution. Trophic changes up to overt venous ulceration are mainly caused by microvascular ischemia and edema formation due to increased capillary permeability and deficient lymphatic drainage. SN - 0003-3197 UR - https://www.unboundmedicine.com/medline/citation/8995340/Microvascular_changes_in_venous_disease:_an_update_ L2 - https://journals.sagepub.com/doi/10.1177/000331979704800105?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub=pubmed DB - PRIME DP - Unbound Medicine ER -