Tags

Type your tag names separated by a space and hit enter

Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris.
J Am Acad Dermatol. 1997 Jan; 36(1):59-66.JA

Abstract

BACKGROUND

Lichen planopilaris usually produces multifocal areas of scarring alopecia. Recently, a condition in postmenopausal women characterized by progressive frontal hairline recession associated with scarring has been described.

OBJECTIVE

Our purpose was to study the clinical and histopathologic features and results of treatment in a group of women with the frontal variant of lichen planopilaris and to compare the immunohistochemical profile of scalp biopsy specimens from this subset with that found in the multifocal variant of lichen planopilaris.

METHOD

The clinical data as well as the histopathologic findings in 16 women with frontal fibrosing alopecia were collated. The immunohistochemical profile of six scalp biopsy specimens from the frontal hairline were compared with six specimens from women with multifocal lichen planopilaris.

RESULTS

In addition to the progressive frontal fibrosing alopecia in all 16 women, total loss or a marked decrease of the eyebrows was observed in 13. No evidence of lichen planus was observed at other sites. In one patient multifocal areas of lichen planopilaris developed in the scalp. The frontal fibrosing alopecia was slowly progressive but has stabilized in five patients. Biopsy specimens from the frontal hairline showed histologic changes identical to lichen planopilaris. Immunophenotyping failed to reveal any significant differences between the frontal and multifocal variants. No effective treatments emerged although oral steroids and antimalarials may temporarily slow the course. Hormone replacement therapy did not appear to influence the course of the alopecia.

CONCLUSION

Progressive frontal fibrosing alopecia is a clinically distinct variant of lichen planopilaris that affects in particular elderly women and frequently involves the eyebrows. The basis for this lichenoid tissue reaction targeting frontal scalp follicles and eyebrows is unknown.

Authors+Show Affiliations

Skin and Cancer Foundation Australia, NSW, Australia.No affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article

Language

eng

PubMed ID

8996262

Citation

Kossard, S, et al. "Postmenopausal Frontal Fibrosing Alopecia: a Frontal Variant of Lichen Planopilaris." Journal of the American Academy of Dermatology, vol. 36, no. 1, 1997, pp. 59-66.
Kossard S, Lee MS, Wilkinson B. Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. J Am Acad Dermatol. 1997;36(1):59-66.
Kossard, S., Lee, M. S., & Wilkinson, B. (1997). Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. Journal of the American Academy of Dermatology, 36(1), 59-66.
Kossard S, Lee MS, Wilkinson B. Postmenopausal Frontal Fibrosing Alopecia: a Frontal Variant of Lichen Planopilaris. J Am Acad Dermatol. 1997;36(1):59-66. PubMed PMID: 8996262.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Postmenopausal frontal fibrosing alopecia: a frontal variant of lichen planopilaris. AU - Kossard,S, AU - Lee,M S, AU - Wilkinson,B, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 59 EP - 66 JF - Journal of the American Academy of Dermatology JO - J. Am. Acad. Dermatol. VL - 36 IS - 1 N2 - BACKGROUND: Lichen planopilaris usually produces multifocal areas of scarring alopecia. Recently, a condition in postmenopausal women characterized by progressive frontal hairline recession associated with scarring has been described. OBJECTIVE: Our purpose was to study the clinical and histopathologic features and results of treatment in a group of women with the frontal variant of lichen planopilaris and to compare the immunohistochemical profile of scalp biopsy specimens from this subset with that found in the multifocal variant of lichen planopilaris. METHOD: The clinical data as well as the histopathologic findings in 16 women with frontal fibrosing alopecia were collated. The immunohistochemical profile of six scalp biopsy specimens from the frontal hairline were compared with six specimens from women with multifocal lichen planopilaris. RESULTS: In addition to the progressive frontal fibrosing alopecia in all 16 women, total loss or a marked decrease of the eyebrows was observed in 13. No evidence of lichen planus was observed at other sites. In one patient multifocal areas of lichen planopilaris developed in the scalp. The frontal fibrosing alopecia was slowly progressive but has stabilized in five patients. Biopsy specimens from the frontal hairline showed histologic changes identical to lichen planopilaris. Immunophenotyping failed to reveal any significant differences between the frontal and multifocal variants. No effective treatments emerged although oral steroids and antimalarials may temporarily slow the course. Hormone replacement therapy did not appear to influence the course of the alopecia. CONCLUSION: Progressive frontal fibrosing alopecia is a clinically distinct variant of lichen planopilaris that affects in particular elderly women and frequently involves the eyebrows. The basis for this lichenoid tissue reaction targeting frontal scalp follicles and eyebrows is unknown. SN - 0190-9622 UR - https://www.unboundmedicine.com/medline/citation/8996262/Postmenopausal_frontal_fibrosing_alopecia:_a_frontal_variant_of_lichen_planopilaris_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0190-9622(97)70326-8 DB - PRIME DP - Unbound Medicine ER -