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The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks.
Eur Neuropsychopharmacol. 1995 Dec; 5(4):457-63.EN

Abstract

The present study was undertaken to investigate the effects of modulation of the N-methyl-D-aspartate (NMDA) receptor on learning and memory. Thus, the performance of rats treated with D-cycloserine, a partial agonist at the glycine recognition site of the NMDA receptor complex, and MK-801, a noncompetitive NMDA receptor antagonist, either alone or concurrently were assessed in radial arm maze and water maze tasks. Administration of MK-801 (0.1 mg/kg, i.p.) impaired acquisition in the water maze (increased escape latency and distance) and working memory in the radial arm maze (increased re-entries) in rats. Moreover, in the radial arm maze, MK-801 disrupted locomotion (increased latencies and decreased arm entries per minute) and impaired the acquisition of reference memory (increased number of errors) performance of rats. D-Cycloserine (0.03, 0.3, 1.0, 3.0, 10 mg/kg, i.p.) had no effects on acquisition or memory performance of control or MK-801-treated rats in either of these tasks. However, D-cycloserine (0.03, 0.3, 3.0 mg/kg) reversed the MK-801-induced disruption in locomotion. Furthermore, 3.0 mg/kg D-cycloserine increased behavioral activity and also decreased the time needed to complete the task in control animals. To conclude, our results suggest that the consequences of NMDA receptor modulation on learning and memory processes and sensorimotor functions may be functionally different or have distinct anatomical locations.

Authors+Show Affiliations

Department of Neurology, University of Kuopio, Finland.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8998397

Citation

Pitkänen, M, et al. "The Effects of D-cycloserine and MK-801 On the Performance of Rats in Two Spatial Learning and Memory Tasks." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 5, no. 4, 1995, pp. 457-63.
Pitkänen M, Sirviö J, MacDonald E, et al. The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. Eur Neuropsychopharmacol. 1995;5(4):457-63.
Pitkänen, M., Sirviö, J., MacDonald, E., Niemi, S., Ekonsalo, T., & Riekkinen, P. (1995). The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 5(4), 457-63.
Pitkänen M, et al. The Effects of D-cycloserine and MK-801 On the Performance of Rats in Two Spatial Learning and Memory Tasks. Eur Neuropsychopharmacol. 1995;5(4):457-63. PubMed PMID: 8998397.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effects of D-cycloserine and MK-801 on the performance of rats in two spatial learning and memory tasks. AU - Pitkänen,M, AU - Sirviö,J, AU - MacDonald,E, AU - Niemi,S, AU - Ekonsalo,T, AU - Riekkinen,P,Sr PY - 1995/12/1/pubmed PY - 2001/3/28/medline PY - 1995/12/1/entrez SP - 457 EP - 63 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 5 IS - 4 N2 - The present study was undertaken to investigate the effects of modulation of the N-methyl-D-aspartate (NMDA) receptor on learning and memory. Thus, the performance of rats treated with D-cycloserine, a partial agonist at the glycine recognition site of the NMDA receptor complex, and MK-801, a noncompetitive NMDA receptor antagonist, either alone or concurrently were assessed in radial arm maze and water maze tasks. Administration of MK-801 (0.1 mg/kg, i.p.) impaired acquisition in the water maze (increased escape latency and distance) and working memory in the radial arm maze (increased re-entries) in rats. Moreover, in the radial arm maze, MK-801 disrupted locomotion (increased latencies and decreased arm entries per minute) and impaired the acquisition of reference memory (increased number of errors) performance of rats. D-Cycloserine (0.03, 0.3, 1.0, 3.0, 10 mg/kg, i.p.) had no effects on acquisition or memory performance of control or MK-801-treated rats in either of these tasks. However, D-cycloserine (0.03, 0.3, 3.0 mg/kg) reversed the MK-801-induced disruption in locomotion. Furthermore, 3.0 mg/kg D-cycloserine increased behavioral activity and also decreased the time needed to complete the task in control animals. To conclude, our results suggest that the consequences of NMDA receptor modulation on learning and memory processes and sensorimotor functions may be functionally different or have distinct anatomical locations. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/8998397/The_effects_of_D_cycloserine_and_MK_801_on_the_performance_of_rats_in_two_spatial_learning_and_memory_tasks_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0924977X9500018K DB - PRIME DP - Unbound Medicine ER -