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Potential antidepressant effects of lemon odor in rats.
Eur Neuropsychopharmacol. 1995 Dec; 5(4):477-80.EN

Abstract

Antidepressant effects brought about by olfactory stimulation with various odorants were investigated with the forced swimming test, a reliable means for screening antidepressant effects. Lemon odor significantly reduced total immobility time and potentiated the imipramine-induced reduction of total immobility time in the test. This synergistic effect of lemon odor and imipramine was not due to lemon odor decreasing the metabolism of imipramine. Lemon odor decreased locomotor activity in the open field, suggesting its effects to differ from those of psychostimulants but to be similar to those of antidepressants. The effects of citral, which is one of the main components of lemon odor, were as strong as those of lemon odor. The remaining odorants tested in this study failed to have any effects on total immobility time in the forced swimming test or on locomotor activity in the open field.

Authors+Show Affiliations

Department of Psychiatry, Mie University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8998400

Citation

Komori, T, et al. "Potential Antidepressant Effects of Lemon Odor in Rats." European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, vol. 5, no. 4, 1995, pp. 477-80.
Komori T, Fujiwara R, Tanida M, et al. Potential antidepressant effects of lemon odor in rats. Eur Neuropsychopharmacol. 1995;5(4):477-80.
Komori, T., Fujiwara, R., Tanida, M., & Nomura, J. (1995). Potential antidepressant effects of lemon odor in rats. European Neuropsychopharmacology : the Journal of the European College of Neuropsychopharmacology, 5(4), 477-80.
Komori T, et al. Potential Antidepressant Effects of Lemon Odor in Rats. Eur Neuropsychopharmacol. 1995;5(4):477-80. PubMed PMID: 8998400.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Potential antidepressant effects of lemon odor in rats. AU - Komori,T, AU - Fujiwara,R, AU - Tanida,M, AU - Nomura,J, PY - 1995/12/1/pubmed PY - 1995/12/1/medline PY - 1995/12/1/entrez SP - 477 EP - 80 JF - European neuropsychopharmacology : the journal of the European College of Neuropsychopharmacology JO - Eur Neuropsychopharmacol VL - 5 IS - 4 N2 - Antidepressant effects brought about by olfactory stimulation with various odorants were investigated with the forced swimming test, a reliable means for screening antidepressant effects. Lemon odor significantly reduced total immobility time and potentiated the imipramine-induced reduction of total immobility time in the test. This synergistic effect of lemon odor and imipramine was not due to lemon odor decreasing the metabolism of imipramine. Lemon odor decreased locomotor activity in the open field, suggesting its effects to differ from those of psychostimulants but to be similar to those of antidepressants. The effects of citral, which is one of the main components of lemon odor, were as strong as those of lemon odor. The remaining odorants tested in this study failed to have any effects on total immobility time in the forced swimming test or on locomotor activity in the open field. SN - 0924-977X UR - https://www.unboundmedicine.com/medline/citation/8998400/Potential_antidepressant_effects_of_lemon_odor_in_rats_ L2 - https://linkinghub.elsevier.com/retrieve/pii/0924977X9500020P DB - PRIME DP - Unbound Medicine ER -