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5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics.
J Microencapsul. 1996 Mar-Apr; 13(2):161-8.JM

Abstract

Cross-linked chitosan microspheres containing 5-Fluorouracil (5-FU) were prepared. Variables believed to be important for microsphere properties were examined; these included: drug and chitosan concentrations, cross-linking process, the type of oil, stirring rate and also additives. Initial 5-FU concentration, the type and concentration of chitosan, the viscosity of oil phase and glutaraldehyde concentration affected drug release from chitosan microspheres. 5-FU release from cross-linked chitosan microspheres is characterized by an initial rapid release of drug. Addition of substances such as alginic acid, chitin, agar, sodium caprylate and stearic acid changed the release properties of 5-FU microspheres.

Authors+Show Affiliations

Marmara University, Haydarpasa, Turkey.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

8999121

Citation

Akbuğa, J, and N Bergişadi. "5-Fluorouracil-loaded Chitosan Microspheres: Preparation and Release Characteristics." Journal of Microencapsulation, vol. 13, no. 2, 1996, pp. 161-8.
Akbuğa J, Bergişadi N. 5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics. J Microencapsul. 1996;13(2):161-8.
Akbuğa, J., & Bergişadi, N. (1996). 5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics. Journal of Microencapsulation, 13(2), 161-8.
Akbuğa J, Bergişadi N. 5-Fluorouracil-loaded Chitosan Microspheres: Preparation and Release Characteristics. J Microencapsul. 1996 Mar-Apr;13(2):161-8. PubMed PMID: 8999121.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - 5-Fluorouracil-loaded chitosan microspheres: preparation and release characteristics. AU - Akbuğa,J, AU - Bergişadi,N, PY - 1996/3/1/pubmed PY - 1996/3/1/medline PY - 1996/3/1/entrez SP - 161 EP - 8 JF - Journal of microencapsulation JO - J Microencapsul VL - 13 IS - 2 N2 - Cross-linked chitosan microspheres containing 5-Fluorouracil (5-FU) were prepared. Variables believed to be important for microsphere properties were examined; these included: drug and chitosan concentrations, cross-linking process, the type of oil, stirring rate and also additives. Initial 5-FU concentration, the type and concentration of chitosan, the viscosity of oil phase and glutaraldehyde concentration affected drug release from chitosan microspheres. 5-FU release from cross-linked chitosan microspheres is characterized by an initial rapid release of drug. Addition of substances such as alginic acid, chitin, agar, sodium caprylate and stearic acid changed the release properties of 5-FU microspheres. SN - 0265-2048 UR - https://www.unboundmedicine.com/medline/citation/8999121/5_Fluorouracil_loaded_chitosan_microspheres:_preparation_and_release_characteristics_ L2 - https://www.tandfonline.com/doi/full/10.3109/02652049609052904 DB - PRIME DP - Unbound Medicine ER -