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Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study.

Abstract

Association between breast cancer risk and the intake of vitamins C and E, retinol, beta (beta)-carotene, dietary fibre, vegetables, fruit and potatoes was examined in The Netherlands Cohort Study, for 62,573 women aged 55-69 years. After 4.3 years of follow-up, 650 incident breast cancer cases were identified. After adjusting for traditional risk factors, breast cancer risk was not influenced by the intake of beta-carotene, vitamin E, dietary fibre, supplements with vitamin C, vegetables or potatoes. Fruit consumption showed a non-significant inverse association with breast cancer risk (RR highest/lowest quintile = 0.76, 95% CI 0.54-1.08). A small reduction in risk was also observed with increasing intake of dietary vitamin C (RR highest/lowest quintile = 0.77, 95% CI 0.55-1.08). For retinol, a weak positive association was observed (RR highest/lowest quintile = 1.24, 95% CI 0.83-1.83). Among subjects with a high intake of polyunsaturated fatty acids (PUFAs), both beta-carotene and vitamin C intake showed a non-significant inverse association with breast cancer risk (P-trend = 0.15 and 0.16 respectively). Our findings do not suggest a strong role, if any, for intake of vitamins C and E, beta-carotene, retinol, dietary fibre, vegetables, fruit and potatoes in the aetiology of breast cancer.

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  • Authors+Show Affiliations

    ,

    TNO Nutrition and Food Research Institute, Zeist, The Netherlands.

    , , , , , ,

    Source

    British journal of cancer 75:1 1997 pg 149-55

    MeSH

    Aged
    Ascorbic Acid
    Breast Neoplasms
    Cohort Studies
    Diet Surveys
    Dietary Fiber
    Female
    Fruit
    Humans
    Middle Aged
    Odds Ratio
    Prospective Studies
    Risk
    Surveys and Questionnaires
    Vegetables
    Vitamin A
    Vitamin E
    beta Carotene

    Pub Type(s)

    Journal Article
    Research Support, Non-U.S. Gov't

    Language

    eng

    PubMed ID

    9000614

    Citation

    Verhoeven, D T., et al. "Vitamins C and E, Retinol, Beta-carotene and Dietary Fibre in Relation to Breast Cancer Risk: a Prospective Cohort Study." British Journal of Cancer, vol. 75, no. 1, 1997, pp. 149-55.
    Verhoeven DT, Assen N, Goldbohm RA, et al. Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. Br J Cancer. 1997;75(1):149-55.
    Verhoeven, D. T., Assen, N., Goldbohm, R. A., Dorant, E., van 't Veer, P., Sturmans, F., ... van den Brandt, P. A. (1997). Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. British Journal of Cancer, 75(1), pp. 149-55.
    Verhoeven DT, et al. Vitamins C and E, Retinol, Beta-carotene and Dietary Fibre in Relation to Breast Cancer Risk: a Prospective Cohort Study. Br J Cancer. 1997;75(1):149-55. PubMed PMID: 9000614.
    * Article titles in AMA citation format should be in sentence-case
    TY - JOUR T1 - Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. AU - Verhoeven,D T, AU - Assen,N, AU - Goldbohm,R A, AU - Dorant,E, AU - van 't Veer,P, AU - Sturmans,F, AU - Hermus,R J, AU - van den Brandt,P A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 149 EP - 55 JF - British journal of cancer JO - Br. J. Cancer VL - 75 IS - 1 N2 - Association between breast cancer risk and the intake of vitamins C and E, retinol, beta (beta)-carotene, dietary fibre, vegetables, fruit and potatoes was examined in The Netherlands Cohort Study, for 62,573 women aged 55-69 years. After 4.3 years of follow-up, 650 incident breast cancer cases were identified. After adjusting for traditional risk factors, breast cancer risk was not influenced by the intake of beta-carotene, vitamin E, dietary fibre, supplements with vitamin C, vegetables or potatoes. Fruit consumption showed a non-significant inverse association with breast cancer risk (RR highest/lowest quintile = 0.76, 95% CI 0.54-1.08). A small reduction in risk was also observed with increasing intake of dietary vitamin C (RR highest/lowest quintile = 0.77, 95% CI 0.55-1.08). For retinol, a weak positive association was observed (RR highest/lowest quintile = 1.24, 95% CI 0.83-1.83). Among subjects with a high intake of polyunsaturated fatty acids (PUFAs), both beta-carotene and vitamin C intake showed a non-significant inverse association with breast cancer risk (P-trend = 0.15 and 0.16 respectively). Our findings do not suggest a strong role, if any, for intake of vitamins C and E, beta-carotene, retinol, dietary fibre, vegetables, fruit and potatoes in the aetiology of breast cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/9000614/Vitamins_C_and_E_retinol_beta_carotene_and_dietary_fibre_in_relation_to_breast_cancer_risk:_a_prospective_cohort_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9000614/ DB - PRIME DP - Unbound Medicine ER -