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Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study.
Br J Cancer 1997; 75(1):149-55BJ

Abstract

Association between breast cancer risk and the intake of vitamins C and E, retinol, beta (beta)-carotene, dietary fibre, vegetables, fruit and potatoes was examined in The Netherlands Cohort Study, for 62,573 women aged 55-69 years. After 4.3 years of follow-up, 650 incident breast cancer cases were identified. After adjusting for traditional risk factors, breast cancer risk was not influenced by the intake of beta-carotene, vitamin E, dietary fibre, supplements with vitamin C, vegetables or potatoes. Fruit consumption showed a non-significant inverse association with breast cancer risk (RR highest/lowest quintile = 0.76, 95% CI 0.54-1.08). A small reduction in risk was also observed with increasing intake of dietary vitamin C (RR highest/lowest quintile = 0.77, 95% CI 0.55-1.08). For retinol, a weak positive association was observed (RR highest/lowest quintile = 1.24, 95% CI 0.83-1.83). Among subjects with a high intake of polyunsaturated fatty acids (PUFAs), both beta-carotene and vitamin C intake showed a non-significant inverse association with breast cancer risk (P-trend = 0.15 and 0.16 respectively). Our findings do not suggest a strong role, if any, for intake of vitamins C and E, beta-carotene, retinol, dietary fibre, vegetables, fruit and potatoes in the aetiology of breast cancer.

Authors+Show Affiliations

TNO Nutrition and Food Research Institute, Zeist, The Netherlands.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9000614

Citation

Verhoeven, D T., et al. "Vitamins C and E, Retinol, Beta-carotene and Dietary Fibre in Relation to Breast Cancer Risk: a Prospective Cohort Study." British Journal of Cancer, vol. 75, no. 1, 1997, pp. 149-55.
Verhoeven DT, Assen N, Goldbohm RA, et al. Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. Br J Cancer. 1997;75(1):149-55.
Verhoeven, D. T., Assen, N., Goldbohm, R. A., Dorant, E., van 't Veer, P., Sturmans, F., ... van den Brandt, P. A. (1997). Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. British Journal of Cancer, 75(1), pp. 149-55.
Verhoeven DT, et al. Vitamins C and E, Retinol, Beta-carotene and Dietary Fibre in Relation to Breast Cancer Risk: a Prospective Cohort Study. Br J Cancer. 1997;75(1):149-55. PubMed PMID: 9000614.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Vitamins C and E, retinol, beta-carotene and dietary fibre in relation to breast cancer risk: a prospective cohort study. AU - Verhoeven,D T, AU - Assen,N, AU - Goldbohm,R A, AU - Dorant,E, AU - van 't Veer,P, AU - Sturmans,F, AU - Hermus,R J, AU - van den Brandt,P A, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 149 EP - 55 JF - British journal of cancer JO - Br. J. Cancer VL - 75 IS - 1 N2 - Association between breast cancer risk and the intake of vitamins C and E, retinol, beta (beta)-carotene, dietary fibre, vegetables, fruit and potatoes was examined in The Netherlands Cohort Study, for 62,573 women aged 55-69 years. After 4.3 years of follow-up, 650 incident breast cancer cases were identified. After adjusting for traditional risk factors, breast cancer risk was not influenced by the intake of beta-carotene, vitamin E, dietary fibre, supplements with vitamin C, vegetables or potatoes. Fruit consumption showed a non-significant inverse association with breast cancer risk (RR highest/lowest quintile = 0.76, 95% CI 0.54-1.08). A small reduction in risk was also observed with increasing intake of dietary vitamin C (RR highest/lowest quintile = 0.77, 95% CI 0.55-1.08). For retinol, a weak positive association was observed (RR highest/lowest quintile = 1.24, 95% CI 0.83-1.83). Among subjects with a high intake of polyunsaturated fatty acids (PUFAs), both beta-carotene and vitamin C intake showed a non-significant inverse association with breast cancer risk (P-trend = 0.15 and 0.16 respectively). Our findings do not suggest a strong role, if any, for intake of vitamins C and E, beta-carotene, retinol, dietary fibre, vegetables, fruit and potatoes in the aetiology of breast cancer. SN - 0007-0920 UR - https://www.unboundmedicine.com/medline/citation/9000614/Vitamins_C_and_E_retinol_beta_carotene_and_dietary_fibre_in_relation_to_breast_cancer_risk:_a_prospective_cohort_study_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9000614/ DB - PRIME DP - Unbound Medicine ER -