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Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies.
Acta Paediatr 1996; 85(12):1503-5AP

Abstract

The usefulness of antigliadin (AGA) and antiendomysium antibodies (EMA) as a screening test for coeliac disease (CD) in 113 Down syndrome (DS) patients (61 children) was evaluated. AGA IgA were present in 22.1%, AGA IgG in 48.6%, EMA in 6.2%. Four symptomatic patients, AGA- and EMA-positive, were affected by CD (3.5%). In three AGA-positive and EMA-positive subjects, permission for intestinal biopsy was refused, while in two AGA-positive and EMA-negative children, the intestinal mucosa was normal. Our study confirms the association of CD and DS, and suggests the usefulness of EMA determination as a test for selecting DS patients for intestinal biopsy.

Authors+Show Affiliations

I Clinica Pediatrica Università La Sapienza, Roma, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9001668

Citation

Bonamico, M, et al. "Down Syndrome and Coeliac Disease: Usefulness of Antigliadin and Antiendomysium Antibodies." Acta Paediatrica (Oslo, Norway : 1992), vol. 85, no. 12, 1996, pp. 1503-5.
Bonamico M, Rasore-Quartino A, Mariani P, et al. Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies. Acta Paediatr. 1996;85(12):1503-5.
Bonamico, M., Rasore-Quartino, A., Mariani, P., Scartezzini, P., Cerruti, P., Tozzi, M. C., ... Gemme, G. (1996). Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies. Acta Paediatrica (Oslo, Norway : 1992), 85(12), pp. 1503-5.
Bonamico M, et al. Down Syndrome and Coeliac Disease: Usefulness of Antigliadin and Antiendomysium Antibodies. Acta Paediatr. 1996;85(12):1503-5. PubMed PMID: 9001668.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Down syndrome and coeliac disease: usefulness of antigliadin and antiendomysium antibodies. AU - Bonamico,M, AU - Rasore-Quartino,A, AU - Mariani,P, AU - Scartezzini,P, AU - Cerruti,P, AU - Tozzi,M C, AU - Cingolani,M, AU - Gemme,G, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 1503 EP - 5 JF - Acta paediatrica (Oslo, Norway : 1992) JO - Acta Paediatr. VL - 85 IS - 12 N2 - The usefulness of antigliadin (AGA) and antiendomysium antibodies (EMA) as a screening test for coeliac disease (CD) in 113 Down syndrome (DS) patients (61 children) was evaluated. AGA IgA were present in 22.1%, AGA IgG in 48.6%, EMA in 6.2%. Four symptomatic patients, AGA- and EMA-positive, were affected by CD (3.5%). In three AGA-positive and EMA-positive subjects, permission for intestinal biopsy was refused, while in two AGA-positive and EMA-negative children, the intestinal mucosa was normal. Our study confirms the association of CD and DS, and suggests the usefulness of EMA determination as a test for selecting DS patients for intestinal biopsy. SN - 0803-5253 UR - https://www.unboundmedicine.com/medline/citation/9001668/Down_syndrome_and_coeliac_disease:_usefulness_of_antigliadin_and_antiendomysium_antibodies_ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&sid=nlm:pubmed&issn=0803-5253&date=1996&volume=85&issue=12&spage=1503 DB - PRIME DP - Unbound Medicine ER -