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[Intraoperative histological study of nonpalpable lesions of the breast].
Chir Ital. 1995; 47(4):9-14.CI

Abstract

The intraoperative frozen section technique has proven to be valid and accurate in the diagnosis of palpable breast lesions, while its use in non-palpable lesions of the breast has been recently discussed. In order to estimate the accuracy of frozen section technique in non-palpable breast lesions we reviewed our series of 672 cases of non-palpable lesions examined intraoperatively between January 1977 and December 1991. Frozen section diagnoses were compared with diagnoses obtained at review of the permanent paraffin sections. A review of the mammographic pattern of each lesion was also carried out. Frozen section diagnosis was replaced by permanent paraffin sections in 22 cases (3.3%). Benign or malignant (in situ and invasive carcinomas) frozen section diagnoses were accurate in 623 of 650 cases (95.8%). Frozen section diagnosis was modified on the basis of permanent sections in 27 cases (4.2%), with 3 false positives and 24 false negatives. Sensitivity and specificity of frozen section technique were 91.7% and 99.2%, respectively. Comparing frozen section and definitive diagnosis according to the mammographic pattern, sensitivity was lower in patients with microcalcifications as the only alteration (88.8%) compared with patients with opacities (94.9%). On the basis of our results the frozen section technique in non-palpable breast lesions is to be considered a valid and reliable diagnostic procedure, particularly in lesions detectable at mammography as an opacity and identifiable on gross examination of the surgical specimen.

Authors+Show Affiliations

Istituto di Anatomia e Istologia Patologica, Università degli Studi, Firenze.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
English Abstract
Journal Article

Language

ita

PubMed ID

9005135

Citation

Bianchi, S, et al. "[Intraoperative Histological Study of Nonpalpable Lesions of the Breast]." Chirurgia Italiana, vol. 47, no. 4, 1995, pp. 9-14.
Bianchi S, Vezzosi V, Palli D, et al. [Intraoperative histological study of nonpalpable lesions of the breast]. Chir Ital. 1995;47(4):9-14.
Bianchi, S., Vezzosi, V., Palli, D., Galli, M., Giorgi, D., & Zampi, G. (1995). [Intraoperative histological study of nonpalpable lesions of the breast]. Chirurgia Italiana, 47(4), 9-14.
Bianchi S, et al. [Intraoperative Histological Study of Nonpalpable Lesions of the Breast]. Chir Ital. 1995;47(4):9-14. PubMed PMID: 9005135.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Intraoperative histological study of nonpalpable lesions of the breast]. AU - Bianchi,S, AU - Vezzosi,V, AU - Palli,D, AU - Galli,M, AU - Giorgi,D, AU - Zampi,G, PY - 1995/1/1/pubmed PY - 1995/1/1/medline PY - 1995/1/1/entrez SP - 9 EP - 14 JF - Chirurgia italiana JO - Chir Ital VL - 47 IS - 4 N2 - The intraoperative frozen section technique has proven to be valid and accurate in the diagnosis of palpable breast lesions, while its use in non-palpable lesions of the breast has been recently discussed. In order to estimate the accuracy of frozen section technique in non-palpable breast lesions we reviewed our series of 672 cases of non-palpable lesions examined intraoperatively between January 1977 and December 1991. Frozen section diagnoses were compared with diagnoses obtained at review of the permanent paraffin sections. A review of the mammographic pattern of each lesion was also carried out. Frozen section diagnosis was replaced by permanent paraffin sections in 22 cases (3.3%). Benign or malignant (in situ and invasive carcinomas) frozen section diagnoses were accurate in 623 of 650 cases (95.8%). Frozen section diagnosis was modified on the basis of permanent sections in 27 cases (4.2%), with 3 false positives and 24 false negatives. Sensitivity and specificity of frozen section technique were 91.7% and 99.2%, respectively. Comparing frozen section and definitive diagnosis according to the mammographic pattern, sensitivity was lower in patients with microcalcifications as the only alteration (88.8%) compared with patients with opacities (94.9%). On the basis of our results the frozen section technique in non-palpable breast lesions is to be considered a valid and reliable diagnostic procedure, particularly in lesions detectable at mammography as an opacity and identifiable on gross examination of the surgical specimen. SN - 0009-4773 UR - https://www.unboundmedicine.com/medline/citation/9005135/[Intraoperative_histological_study_of_nonpalpable_lesions_of_the_breast]_ L2 - https://medlineplus.gov/breastdiseases.html DB - PRIME DP - Unbound Medicine ER -