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Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse.
J Invest Dermatol. 1997 Feb; 108(2):133-8.JI

Abstract

Many studies report that sunscreens effective against UVR-induced inflammation afford poor protection against immunosuppression. We have studied the relationship between photoprotection of inflammation and immunosuppression with monochromatic UVB (Philips TL01 tubes, lambda max = 311 nm) to remove possible confounding effects of differences in end point action spectra. Dose-response curves for edema and systemic suppression of contact hypersensitivity (CHS) in HRA.HRII-c/+/Skh mice showed that suppression of CHS was more sensitive to UVB irradiation by a factor of 2. The UVB dose-response curve for murine edema was similar to that for human erythema, with threshold doses of 773 mJ x cm(-2) and 632 mJ x cm(-2), respectively. The protection afforded by two UVB filters, octyl dimethyl para-aminobenzoic acid and 2-ethylhexyl-4'-methoxycinnamate, prepared in an identical vehicle, each with the same optical density at 311 nm, was tested in mice. We applied sunscreen to all exposed skin or to transpore tape above the irradiation cages, prior to exposure with 2.8 minimal edema doses. Topical or tape application of both sunscreens protected totally against edema but only partially against immunosuppression, with no significant difference in protection between the two application techniques (p > 0.4). A sunscreen protection factor of 4 in vivo was determined for 2-ethylhexyl-4'-methoxycinnamate for both edema and immunosuppression. Failure of the sunscreens to protect completely against immunosuppression was due to the ability of subedemal doses of UVB to induce substantial immunosuppression and not, as previously suggested, to any skin interaction.

Authors+Show Affiliations

Department of Photobiology, St. John's Institute of Dermatology, United Medical and Dental Schools of Guy's and St Thomas's Hospital, University of London, U.K.No affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9008224

Citation

Walker, S L., and A R. Young. "Sunscreens Offer the Same UVB Protection Factors for Inflammation and Immunosuppression in the Mouse." The Journal of Investigative Dermatology, vol. 108, no. 2, 1997, pp. 133-8.
Walker SL, Young AR. Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse. J Invest Dermatol. 1997;108(2):133-8.
Walker, S. L., & Young, A. R. (1997). Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse. The Journal of Investigative Dermatology, 108(2), 133-8.
Walker SL, Young AR. Sunscreens Offer the Same UVB Protection Factors for Inflammation and Immunosuppression in the Mouse. J Invest Dermatol. 1997;108(2):133-8. PubMed PMID: 9008224.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Sunscreens offer the same UVB protection factors for inflammation and immunosuppression in the mouse. AU - Walker,S L, AU - Young,A R, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 133 EP - 8 JF - The Journal of investigative dermatology JO - J Invest Dermatol VL - 108 IS - 2 N2 - Many studies report that sunscreens effective against UVR-induced inflammation afford poor protection against immunosuppression. We have studied the relationship between photoprotection of inflammation and immunosuppression with monochromatic UVB (Philips TL01 tubes, lambda max = 311 nm) to remove possible confounding effects of differences in end point action spectra. Dose-response curves for edema and systemic suppression of contact hypersensitivity (CHS) in HRA.HRII-c/+/Skh mice showed that suppression of CHS was more sensitive to UVB irradiation by a factor of 2. The UVB dose-response curve for murine edema was similar to that for human erythema, with threshold doses of 773 mJ x cm(-2) and 632 mJ x cm(-2), respectively. The protection afforded by two UVB filters, octyl dimethyl para-aminobenzoic acid and 2-ethylhexyl-4'-methoxycinnamate, prepared in an identical vehicle, each with the same optical density at 311 nm, was tested in mice. We applied sunscreen to all exposed skin or to transpore tape above the irradiation cages, prior to exposure with 2.8 minimal edema doses. Topical or tape application of both sunscreens protected totally against edema but only partially against immunosuppression, with no significant difference in protection between the two application techniques (p > 0.4). A sunscreen protection factor of 4 in vivo was determined for 2-ethylhexyl-4'-methoxycinnamate for both edema and immunosuppression. Failure of the sunscreens to protect completely against immunosuppression was due to the ability of subedemal doses of UVB to induce substantial immunosuppression and not, as previously suggested, to any skin interaction. SN - 0022-202X UR - https://www.unboundmedicine.com/medline/citation/9008224/Sunscreens_offer_the_same_UVB_protection_factors_for_inflammation_and_immunosuppression_in_the_mouse_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0022-202X(15)42795-2 DB - PRIME DP - Unbound Medicine ER -