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Adenosine receptor on human basophils: modulation of histamine release.
J Immunol. 1979 Oct; 123(4):1473-7.JI

Abstract

Adenosine, at physiologic concentrations, inhibits in vitro IgE-mediated human basophil histamine release in a dose-dependent fashion. The inhibition dose-response curve is paralleled by an adenosine-induced increase in cAMP levels of human leukocyte preparations. Further evidence that the adenosine effect is related to changes in cAMP levels is that the nucleoside inhibits only in the first stage of antigen-induced histamine release and fails to inhibit the release caused by ionophore A23187. A poorly metabolized derivative of adenosine, 2-chloroadenosine inhibits as effectively as adenosine; dipyridamole, which blocks adenosine uptake, does not impair the inhibition caused by adenosine. Finally, theophylline, which is a competitive antagonist of adenosine in human lymphocytes also blocks the inhibition of release caused by adenosine. These data suggest that adenosine acts via a specific cell-surface receptor linked to adenylate cyclase. It appears that the human basophil has a specific receptor for adenosine and that this nucleoside may modulate the in vivo release of the mediators of immediate hypersensitivity reactions.

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Publisher Full Text

Authors

Marone G
No affiliation info available
Findlay SR
No affiliation info available
Lichtenstein LM
No affiliation info available

MeSH

AdenosineAdenylyl CyclasesBasophilsBinding SitesCyclic AMPDose-Response Relationship, ImmunologicHistamine ReleaseHumansTheophylline

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

90084

Citation

Marone, G, et al. "Adenosine Receptor On Human Basophils: Modulation of Histamine Release." Journal of Immunology (Baltimore, Md. : 1950), vol. 123, no. 4, 1979, pp. 1473-7.
Marone G, Findlay SR, Lichtenstein LM. Adenosine receptor on human basophils: modulation of histamine release. J Immunol. 1979;123(4):1473-7.
Marone, G., Findlay, S. R., & Lichtenstein, L. M. (1979). Adenosine receptor on human basophils: modulation of histamine release. Journal of Immunology (Baltimore, Md. : 1950), 123(4), 1473-7.
Marone G, Findlay SR, Lichtenstein LM. Adenosine Receptor On Human Basophils: Modulation of Histamine Release. J Immunol. 1979;123(4):1473-7. PubMed PMID: 90084.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Adenosine receptor on human basophils: modulation of histamine release. AU - Marone,G, AU - Findlay,S R, AU - Lichtenstein,L M, PY - 1979/10/1/pubmed PY - 1979/10/1/medline PY - 1979/10/1/entrez SP - 1473 EP - 7 JF - Journal of immunology (Baltimore, Md. : 1950) JO - J Immunol VL - 123 IS - 4 N2 - Adenosine, at physiologic concentrations, inhibits in vitro IgE-mediated human basophil histamine release in a dose-dependent fashion. The inhibition dose-response curve is paralleled by an adenosine-induced increase in cAMP levels of human leukocyte preparations. Further evidence that the adenosine effect is related to changes in cAMP levels is that the nucleoside inhibits only in the first stage of antigen-induced histamine release and fails to inhibit the release caused by ionophore A23187. A poorly metabolized derivative of adenosine, 2-chloroadenosine inhibits as effectively as adenosine; dipyridamole, which blocks adenosine uptake, does not impair the inhibition caused by adenosine. Finally, theophylline, which is a competitive antagonist of adenosine in human lymphocytes also blocks the inhibition of release caused by adenosine. These data suggest that adenosine acts via a specific cell-surface receptor linked to adenylate cyclase. It appears that the human basophil has a specific receptor for adenosine and that this nucleoside may modulate the in vivo release of the mediators of immediate hypersensitivity reactions. SN - 0022-1767 UR - https://www.unboundmedicine.com/medline/citation/90084/Adenosine_receptor_on_human_basophils:_modulation_of_histamine_release_ L2 - https://www.jimmunol.org/lookup/pmidlookup?view=long&pmid=90084 DB - PRIME DP - Unbound Medicine ER -