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Clinical features in persons with a family history of diabetes compared to controls (The Second Generation Fredericia Study).
J Intern Med. 1996 Dec; 240(6):381-7.JI

Abstract

OBJECTIVE

To compare clinical and biochemical features in non-diabetic persons with a family history of non-insulin dependent diabetes mellitus (NIDDM) to non-diabetic persons without a family history of diabetes.

DESIGN

Cross-sectional study.

SETTING

Population-based survey in Fredericia, Denmark.

SUBJECTS

Seven hundred and forty subjects, the second generation of an earlier defined cohort was examined. The median age was 48 (range 26-65) years. Of the 740 subjects 696 were non-diabetic.

INTERVENTIONS

The subjects had a clinical examination.

MAIN OUTCOME MEASURES

Known risk factors for development of diabetes and cardiovascular disease.

RESULTS

More offspring of diabetic persons had NIDDM (chi 2 = 6.36, P < 0.05). Non-diabetic males with a family history of diabetes had a higher BMI fasting blood glucose, and triglycerides compared to males without a family history of diabetes. Non-diabetic females with a family history of diabetes had a higher BMI, fasting blood glucose. HbA1C, diastolic blood pressure, and lower HDL-cholesterol than female offspring of non-diabetics. In a multiple regression model we found that non-diabetic off-spring of diabetic persons had higher fasting blood glucose and HbA1C compared to offspring of non-diabetic persons when adjusted for the independent variables age, BMI, WHR, and sex.

CONCLUSION

Our results may indicate that the only inherited factors from NIDDM patients are plasma blood glucose. HbA1C and increased BMI which may be an indication for later diabetes, whereas other cardiovascular risk factors may be inherited independently of diabetes but associated with BMI.

Authors+Show Affiliations

Medical Department M (Diabetes and Endocrinology), Aarhus Kommunehospital, Denmark.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9010385

Citation

Vestbo, E, et al. "Clinical Features in Persons With a Family History of Diabetes Compared to Controls (The Second Generation Fredericia Study)." Journal of Internal Medicine, vol. 240, no. 6, 1996, pp. 381-7.
Vestbo E, Damsgaard EM, Frøland A, et al. Clinical features in persons with a family history of diabetes compared to controls (The Second Generation Fredericia Study). J Intern Med. 1996;240(6):381-7.
Vestbo, E., Damsgaard, E. M., Frøland, A., & Mogensen, C. E. (1996). Clinical features in persons with a family history of diabetes compared to controls (The Second Generation Fredericia Study). Journal of Internal Medicine, 240(6), 381-7.
Vestbo E, et al. Clinical Features in Persons With a Family History of Diabetes Compared to Controls (The Second Generation Fredericia Study). J Intern Med. 1996;240(6):381-7. PubMed PMID: 9010385.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Clinical features in persons with a family history of diabetes compared to controls (The Second Generation Fredericia Study). AU - Vestbo,E, AU - Damsgaard,E M, AU - Frøland,A, AU - Mogensen,C E, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 381 EP - 7 JF - Journal of internal medicine JO - J Intern Med VL - 240 IS - 6 N2 - OBJECTIVE: To compare clinical and biochemical features in non-diabetic persons with a family history of non-insulin dependent diabetes mellitus (NIDDM) to non-diabetic persons without a family history of diabetes. DESIGN: Cross-sectional study. SETTING: Population-based survey in Fredericia, Denmark. SUBJECTS: Seven hundred and forty subjects, the second generation of an earlier defined cohort was examined. The median age was 48 (range 26-65) years. Of the 740 subjects 696 were non-diabetic. INTERVENTIONS: The subjects had a clinical examination. MAIN OUTCOME MEASURES: Known risk factors for development of diabetes and cardiovascular disease. RESULTS: More offspring of diabetic persons had NIDDM (chi 2 = 6.36, P < 0.05). Non-diabetic males with a family history of diabetes had a higher BMI fasting blood glucose, and triglycerides compared to males without a family history of diabetes. Non-diabetic females with a family history of diabetes had a higher BMI, fasting blood glucose. HbA1C, diastolic blood pressure, and lower HDL-cholesterol than female offspring of non-diabetics. In a multiple regression model we found that non-diabetic off-spring of diabetic persons had higher fasting blood glucose and HbA1C compared to offspring of non-diabetic persons when adjusted for the independent variables age, BMI, WHR, and sex. CONCLUSION: Our results may indicate that the only inherited factors from NIDDM patients are plasma blood glucose. HbA1C and increased BMI which may be an indication for later diabetes, whereas other cardiovascular risk factors may be inherited independently of diabetes but associated with BMI. SN - 0954-6820 UR - https://www.unboundmedicine.com/medline/citation/9010385/Clinical_features_in_persons_with_a_family_history_of_diabetes_compared_to_controls__The_Second_Generation_Fredericia_Study__ L2 - https://onlinelibrary.wiley.com/resolve/openurl?genre=article&amp;sid=nlm:pubmed&amp;issn=0954-6820&amp;date=1996&amp;volume=240&amp;issue=6&amp;spage=381 DB - PRIME DP - Unbound Medicine ER -