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Effect of oral and transdermal hormone replacement therapy on lipid profile and Lp(a) level in menopausal women with hypercholesterolemia.
Int J Fertil Menopausal Stud. 1996 Nov-Dec; 41(6):509-15.IJ

Abstract

OBJECTIVE

The aim of this randomized clinical study was to evaluate the hormonal replacement therapy (HRT) effect on plasma lipoproteins and Lp(a) profile in 42 menopausal women with primary hypercholesterolemia (total cholesterol > 240 mg/dL).

SETTING

University clinic.

PATIENTS AND METHODS

42 hypercholesterolemic menopausal women were randomly assigned to the following groups; (1) transdermal estradiol, 50 micrograms + medroxyprogesterone 10 mg/day for days; (2) conjugated equine estrogens, 0.625 mg/day + medroxyprogesterone acetate 10 mg/day for 12 days; (3) no treatment. At baseline and after 3 and 6 months two blood samples were collected with a 24-hour interval in order to reduce intraindividual and laboratory variability. Serum total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol, and Lp(a) were determined.

RESULTS

Total cholesterol and LDL cholesterol significantly decreased after 6 months in both treated groups in comparison to untreated women; HDL cholesterol and triglycerides showed only minimal changes. HRT at the dosage utilized in the study did not seem influence the Lp(a) concentrations after 3 and 6 months.

CONCLUSIONS

Both transdermal and oral estrogens at medium dosage have a favorable influence on total cholesterol and LDL-cholesterol level of hypercholesterolemic menopausal women, but Lp(a) remains resistant to manipulation.

Authors+Show Affiliations

I. Clinica Ostetrica e Ginecologica, Università degli Studi di Roma La Sapienza, Rome, Italy.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Clinical Trial
Comparative Study
Journal Article
Randomized Controlled Trial

Language

eng

PubMed ID

9010744

Citation

Perrone, G, et al. "Effect of Oral and Transdermal Hormone Replacement Therapy On Lipid Profile and Lp(a) Level in Menopausal Women With Hypercholesterolemia." International Journal of Fertility and Menopausal Studies, vol. 41, no. 6, 1996, pp. 509-15.
Perrone G, Stefanutti C, Galoppi P, et al. Effect of oral and transdermal hormone replacement therapy on lipid profile and Lp(a) level in menopausal women with hypercholesterolemia. Int J Fertil Menopausal Stud. 1996;41(6):509-15.
Perrone, G., Stefanutti, C., Galoppi, P., Anelli, G., Capri, O., Lucani, G., Vivenzio, A., Mazzarella, B., & Zichella, L. (1996). Effect of oral and transdermal hormone replacement therapy on lipid profile and Lp(a) level in menopausal women with hypercholesterolemia. International Journal of Fertility and Menopausal Studies, 41(6), 509-15.
Perrone G, et al. Effect of Oral and Transdermal Hormone Replacement Therapy On Lipid Profile and Lp(a) Level in Menopausal Women With Hypercholesterolemia. Int J Fertil Menopausal Stud. 1996 Nov-Dec;41(6):509-15. PubMed PMID: 9010744.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Effect of oral and transdermal hormone replacement therapy on lipid profile and Lp(a) level in menopausal women with hypercholesterolemia. AU - Perrone,G, AU - Stefanutti,C, AU - Galoppi,P, AU - Anelli,G, AU - Capri,O, AU - Lucani,G, AU - Vivenzio,A, AU - Mazzarella,B, AU - Zichella,L, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - 509 EP - 15 JF - International journal of fertility and menopausal studies JO - Int J Fertil Menopausal Stud VL - 41 IS - 6 N2 - OBJECTIVE: The aim of this randomized clinical study was to evaluate the hormonal replacement therapy (HRT) effect on plasma lipoproteins and Lp(a) profile in 42 menopausal women with primary hypercholesterolemia (total cholesterol > 240 mg/dL). SETTING: University clinic. PATIENTS AND METHODS: 42 hypercholesterolemic menopausal women were randomly assigned to the following groups; (1) transdermal estradiol, 50 micrograms + medroxyprogesterone 10 mg/day for days; (2) conjugated equine estrogens, 0.625 mg/day + medroxyprogesterone acetate 10 mg/day for 12 days; (3) no treatment. At baseline and after 3 and 6 months two blood samples were collected with a 24-hour interval in order to reduce intraindividual and laboratory variability. Serum total cholesterol, HDL cholesterol, triglycerides, LDL cholesterol, and Lp(a) were determined. RESULTS: Total cholesterol and LDL cholesterol significantly decreased after 6 months in both treated groups in comparison to untreated women; HDL cholesterol and triglycerides showed only minimal changes. HRT at the dosage utilized in the study did not seem influence the Lp(a) concentrations after 3 and 6 months. CONCLUSIONS: Both transdermal and oral estrogens at medium dosage have a favorable influence on total cholesterol and LDL-cholesterol level of hypercholesterolemic menopausal women, but Lp(a) remains resistant to manipulation. SN - 1069-3130 UR - https://www.unboundmedicine.com/medline/citation/9010744/Effect_of_oral_and_transdermal_hormone_replacement_therapy_on_lipid_profile_and_Lp_a__level_in_menopausal_women_with_hypercholesterolemia_ L2 - http://www.diseaseinfosearch.org/result/3550 DB - PRIME DP - Unbound Medicine ER -