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[Graft dysfunction, acute rejection and bronchiolitis obliterans in lung and heart-lung transplantation].
Rev Mal Respir 1996; 13(5 Suppl):S31-40RM

Abstract

Three complications which influence both survival and quality of life in transplanted patients will be the object of this chapter. Graft dysfunction: this is a severe re-implantation oedema leading to inefficiency of the graft as regards haemostasis whether or not associated with haemodynamic complications. The liberation of free radicals and/or cytokines induced by ischemia-reperfusion of the graft plays an important role in the pathogenesis of this syndrome. Acute rejection: the mechanism is complex leading to the intervention of an immune response stimulated by the detection of allo-antigens. The clinical picture is often non-specific. Treatment requires boluses of methyl prednisolone completed by decreasing dose of corticosteroid therapy orally. The syndrome of bronchiolitis obliterans: this is a progressive failure of the airways. This syndrome occurs in the long term in 50% of patients and presents with progressive dyspnoea associated with persistent or recurrent cough. The pathogenesis is brought about principally by a chronic rejection with a specific cytotoxic reaction of T lymphocytes against the airway epithelium which expresses Class II major histocompatibility antigens. Attempts at curative treatment can be extremely deceptive and leads to, at best, a slowing in decline of respiratory function.

Authors+Show Affiliations

Service de Pneumologie et Réanimation, Hôpital Beaujon, Clichy, France.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

English Abstract
Journal Article
Review

Language

fre

PubMed ID

9011909

Citation

Sleiman, C, et al. "[Graft Dysfunction, Acute Rejection and Bronchiolitis Obliterans in Lung and Heart-lung Transplantation]." Revue Des Maladies Respiratoires, vol. 13, no. 5 Suppl, 1996, pp. S31-40.
Sleiman C, Groussard O, Mal H, et al. [Graft dysfunction, acute rejection and bronchiolitis obliterans in lung and heart-lung transplantation]. Rev Mal Respir. 1996;13(5 Suppl):S31-40.
Sleiman, C., Groussard, O., Mal, H., & Fournier, M. (1996). [Graft dysfunction, acute rejection and bronchiolitis obliterans in lung and heart-lung transplantation]. Revue Des Maladies Respiratoires, 13(5 Suppl), pp. S31-40.
Sleiman C, et al. [Graft Dysfunction, Acute Rejection and Bronchiolitis Obliterans in Lung and Heart-lung Transplantation]. Rev Mal Respir. 1996;13(5 Suppl):S31-40. PubMed PMID: 9011909.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Graft dysfunction, acute rejection and bronchiolitis obliterans in lung and heart-lung transplantation]. AU - Sleiman,C, AU - Groussard,O, AU - Mal,H, AU - Fournier,M, PY - 1996/11/1/pubmed PY - 1996/11/1/medline PY - 1996/11/1/entrez SP - S31 EP - 40 JF - Revue des maladies respiratoires JO - Rev Mal Respir VL - 13 IS - 5 Suppl N2 - Three complications which influence both survival and quality of life in transplanted patients will be the object of this chapter. Graft dysfunction: this is a severe re-implantation oedema leading to inefficiency of the graft as regards haemostasis whether or not associated with haemodynamic complications. The liberation of free radicals and/or cytokines induced by ischemia-reperfusion of the graft plays an important role in the pathogenesis of this syndrome. Acute rejection: the mechanism is complex leading to the intervention of an immune response stimulated by the detection of allo-antigens. The clinical picture is often non-specific. Treatment requires boluses of methyl prednisolone completed by decreasing dose of corticosteroid therapy orally. The syndrome of bronchiolitis obliterans: this is a progressive failure of the airways. This syndrome occurs in the long term in 50% of patients and presents with progressive dyspnoea associated with persistent or recurrent cough. The pathogenesis is brought about principally by a chronic rejection with a specific cytotoxic reaction of T lymphocytes against the airway epithelium which expresses Class II major histocompatibility antigens. Attempts at curative treatment can be extremely deceptive and leads to, at best, a slowing in decline of respiratory function. SN - 0761-8425 UR - https://www.unboundmedicine.com/medline/citation/9011909/[Graft_dysfunction_acute_rejection_and_bronchiolitis_obliterans_in_lung_and_heart_lung_transplantation]_ L2 - http://www.diseaseinfosearch.org/result/971 DB - PRIME DP - Unbound Medicine ER -