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Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.
Am J Hum Genet 1997; 60(2):439-46AJ

Abstract

The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the APOE epsilon2 allele (OR[epsilon2] = 0.5 with 95% CI = 0.3-0.98; P = .012) were retrieved. An effect of the epsilon4 allele dosage on susceptibility was confirmed (OR[epsilon4/epsilon4] vs. the epsilon3/epsilon3 genotype = 11.2 [95% CI = 4.0-31.6]; OR[epsilon3/epsilon4] vs. the epsilon3/epsilon3 genotype = 2.2 [95% CI = 1.5-3.5]). The frequency of the epsilon4 allele was lower in male cases than in female cases, but, since a similar difference was found in controls, this does not lead to a difference in OR between sex. ORs for the epsilon4 allele versus the epsilon3 allele, OR(epsilon4), were not equal in all age classes: OR(epsilon4) in the extreme groups with onset at < 60 years or > 79 years were significantly lower than those from the age groups 60-79 years. In epsilon3/epsilon4 individuals, sex-specific lifetime risk estimates by age 85 years (i.e., sex-specific penetrances by age 85 years) were 0.14 (95% CI 0.04-0.30) for men and 0.17 (95% CI 0.09-0.28) for women.

Authors+Show Affiliations

INSERM U155, Château de Longchamp, Paris, France.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9012418

Citation

Bickeböller, H, et al. "Apolipoprotein E and Alzheimer Disease: Genotype-specific Risks By Age and Sex." American Journal of Human Genetics, vol. 60, no. 2, 1997, pp. 439-46.
Bickeböller H, Campion D, Brice A, et al. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. Am J Hum Genet. 1997;60(2):439-46.
Bickeböller, H., Campion, D., Brice, A., Amouyel, P., Hannequin, D., Didierjean, O., ... Clerget-Darpoux, F. (1997). Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. American Journal of Human Genetics, 60(2), pp. 439-46.
Bickeböller H, et al. Apolipoprotein E and Alzheimer Disease: Genotype-specific Risks By Age and Sex. Am J Hum Genet. 1997;60(2):439-46. PubMed PMID: 9012418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. AU - Bickeböller,H, AU - Campion,D, AU - Brice,A, AU - Amouyel,P, AU - Hannequin,D, AU - Didierjean,O, AU - Penet,C, AU - Martin,C, AU - Pérez-Tur,J, AU - Michon,A, AU - Dubois,B, AU - Ledoze,F, AU - Thomas-Anterion,C, AU - Pasquier,F, AU - Puel,M, AU - Demonet,J F, AU - Moreaud,O, AU - Babron,M C, AU - Meulien,D, AU - Guez,D, AU - Chartier-Harlin,M C, AU - Frebourg,T, AU - Agid,Y, AU - Martinez,M, AU - Clerget-Darpoux,F, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 439 EP - 46 JF - American journal of human genetics JO - Am. J. Hum. Genet. VL - 60 IS - 2 N2 - The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the APOE epsilon2 allele (OR[epsilon2] = 0.5 with 95% CI = 0.3-0.98; P = .012) were retrieved. An effect of the epsilon4 allele dosage on susceptibility was confirmed (OR[epsilon4/epsilon4] vs. the epsilon3/epsilon3 genotype = 11.2 [95% CI = 4.0-31.6]; OR[epsilon3/epsilon4] vs. the epsilon3/epsilon3 genotype = 2.2 [95% CI = 1.5-3.5]). The frequency of the epsilon4 allele was lower in male cases than in female cases, but, since a similar difference was found in controls, this does not lead to a difference in OR between sex. ORs for the epsilon4 allele versus the epsilon3 allele, OR(epsilon4), were not equal in all age classes: OR(epsilon4) in the extreme groups with onset at < 60 years or > 79 years were significantly lower than those from the age groups 60-79 years. In epsilon3/epsilon4 individuals, sex-specific lifetime risk estimates by age 85 years (i.e., sex-specific penetrances by age 85 years) were 0.14 (95% CI 0.04-0.30) for men and 0.17 (95% CI 0.09-0.28) for women. SN - 0002-9297 UR - https://www.unboundmedicine.com/medline/citation/9012418/Apolipoprotein_E_and_Alzheimer_disease:_genotype_specific_risks_by_age_and_sex_ L2 - https://www.ncbi.nlm.nih.gov/pmc/articles/pmid/9012418/ DB - PRIME DP - Unbound Medicine ER -