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Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex.
Am J Hum Genet. 1997 Feb; 60(2):439-46.AJ

Abstract

The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the APOE epsilon2 allele (OR[epsilon2] = 0.5 with 95% CI = 0.3-0.98; P = .012) were retrieved. An effect of the epsilon4 allele dosage on susceptibility was confirmed (OR[epsilon4/epsilon4] vs. the epsilon3/epsilon3 genotype = 11.2 [95% CI = 4.0-31.6]; OR[epsilon3/epsilon4] vs. the epsilon3/epsilon3 genotype = 2.2 [95% CI = 1.5-3.5]). The frequency of the epsilon4 allele was lower in male cases than in female cases, but, since a similar difference was found in controls, this does not lead to a difference in OR between sex. ORs for the epsilon4 allele versus the epsilon3 allele, OR(epsilon4), were not equal in all age classes: OR(epsilon4) in the extreme groups with onset at < 60 years or > 79 years were significantly lower than those from the age groups 60-79 years. In epsilon3/epsilon4 individuals, sex-specific lifetime risk estimates by age 85 years (i.e., sex-specific penetrances by age 85 years) were 0.14 (95% CI 0.04-0.30) for men and 0.17 (95% CI 0.09-0.28) for women.

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Authors+Show Affiliations

Bickeböller H
INSERM U155, Château de Longchamp, Paris, France.
Campion D
No affiliation info available
Brice A
No affiliation info available
Amouyel P
No affiliation info available
Hannequin D
No affiliation info available
Didierjean O
No affiliation info available
Penet C
No affiliation info available
Martin C
No affiliation info available
Pérez-Tur J
No affiliation info available
Michon A
No affiliation info available
Dubois B
No affiliation info available
Ledoze F
No affiliation info available
Thomas-Anterion C
No affiliation info available
Pasquier F
No affiliation info available
Puel M
No affiliation info available
Demonet JF
No affiliation info available
Moreaud O
No affiliation info available
Babron MC
No affiliation info available
Meulien D
No affiliation info available
Guez D
No affiliation info available
Chartier-Harlin MC
No affiliation info available
Frebourg T
No affiliation info available
Agid Y
No affiliation info available
Martinez M
No affiliation info available
Clerget-Darpoux F
No affiliation info available

MeSH

Age of OnsetAgedAged, 80 and overAgingAlzheimer DiseaseApolipoprotein E2Apolipoprotein E3Apolipoprotein E4Apolipoproteins ECase-Control StudiesFemaleGenetic Predisposition to DiseaseGenotypeHeterozygoteHomozygoteHumansMaleMiddle AgedOdds RatioRisk FactorsSex Characteristics

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9012418

Citation

Bickeböller, H, et al. "Apolipoprotein E and Alzheimer Disease: Genotype-specific Risks By Age and Sex." American Journal of Human Genetics, vol. 60, no. 2, 1997, pp. 439-46.
Bickeböller H, Campion D, Brice A, et al. Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. Am J Hum Genet. 1997;60(2):439-46.
Bickeböller, H., Campion, D., Brice, A., Amouyel, P., Hannequin, D., Didierjean, O., Penet, C., Martin, C., Pérez-Tur, J., Michon, A., Dubois, B., Ledoze, F., Thomas-Anterion, C., Pasquier, F., Puel, M., Demonet, J. F., Moreaud, O., Babron, M. C., Meulien, D., ... Clerget-Darpoux, F. (1997). Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. American Journal of Human Genetics, 60(2), 439-46.
Bickeböller H, et al. Apolipoprotein E and Alzheimer Disease: Genotype-specific Risks By Age and Sex. Am J Hum Genet. 1997;60(2):439-46. PubMed PMID: 9012418.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Apolipoprotein E and Alzheimer disease: genotype-specific risks by age and sex. AU - Bickeböller,H, AU - Campion,D, AU - Brice,A, AU - Amouyel,P, AU - Hannequin,D, AU - Didierjean,O, AU - Penet,C, AU - Martin,C, AU - Pérez-Tur,J, AU - Michon,A, AU - Dubois,B, AU - Ledoze,F, AU - Thomas-Anterion,C, AU - Pasquier,F, AU - Puel,M, AU - Demonet,J F, AU - Moreaud,O, AU - Babron,M C, AU - Meulien,D, AU - Guez,D, AU - Chartier-Harlin,M C, AU - Frebourg,T, AU - Agid,Y, AU - Martinez,M, AU - Clerget-Darpoux,F, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 439 EP - 46 JF - American journal of human genetics JO - Am J Hum Genet VL - 60 IS - 2 N2 - The distribution of apolipoprotein E (APOE) genotypes as a function of age and sex has been examined in a French population of 417 Alzheimer disease (AD) patients and 1,030 control subjects. When compared to the APOE epsilon3 allele, an increased risk associated with the APOE epsilon4 allele (odds ratio [OR] [epsilon4] = 2.7 with 95% confidence interval [CI] = 2.0-3.6; P < .001) and a protective effect of the APOE epsilon2 allele (OR[epsilon2] = 0.5 with 95% CI = 0.3-0.98; P = .012) were retrieved. An effect of the epsilon4 allele dosage on susceptibility was confirmed (OR[epsilon4/epsilon4] vs. the epsilon3/epsilon3 genotype = 11.2 [95% CI = 4.0-31.6]; OR[epsilon3/epsilon4] vs. the epsilon3/epsilon3 genotype = 2.2 [95% CI = 1.5-3.5]). The frequency of the epsilon4 allele was lower in male cases than in female cases, but, since a similar difference was found in controls, this does not lead to a difference in OR between sex. ORs for the epsilon4 allele versus the epsilon3 allele, OR(epsilon4), were not equal in all age classes: OR(epsilon4) in the extreme groups with onset at < 60 years or > 79 years were significantly lower than those from the age groups 60-79 years. In epsilon3/epsilon4 individuals, sex-specific lifetime risk estimates by age 85 years (i.e., sex-specific penetrances by age 85 years) were 0.14 (95% CI 0.04-0.30) for men and 0.17 (95% CI 0.09-0.28) for women. SN - 0002-9297 UR - https://www.unboundmedicine.com/medline/citation/9012418/Apolipoprotein_E_and_Alzheimer_disease:_genotype_specific_risks_by_age_and_sex_ DB - PRIME DP - Unbound Medicine ER -