Tags

Type your tag names separated by a space and hit enter

Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination.
J Anal Toxicol. 1997 Jan-Feb; 21(1):54-8.JA

Abstract

A simple, extractive heptafluoro-n-butyrylation with Extrelut columns was devised to simultaneously measure methamphetamine (MAMP), amphetamine (AMP), 4-hydroxymethamphetamine (HMAMP), and 4-hydroxyamphetamine (HAMP) in biological materials by gas chromatography-mass spectrometry (GC-MS) using 4-methoxymethamphetamine-d5 as the internal standard. Human urine, human whole blood, and porcine skeletal muscle spiked with the stimulant standards were used for evaluating the method. After deproteinization and adjustment of the pH to 12.6, the sample was applied to an Extrelut column. Using the present method, AMP, MAMP, and HMAMP could be determined in an actual forensic case study.

Authors+Show Affiliations

Department of Forensic Medicine, Fukuoka University School of Medicine, Japan.No affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9013294

Citation

Hara, K, et al. "Simple Extractive Derivatization of Methamphetamine and Its Metabolites in Biological Materials With Extrelut Columns for Their GC-MS Determination." Journal of Analytical Toxicology, vol. 21, no. 1, 1997, pp. 54-8.
Hara K, Kashimura S, Hieda Y, et al. Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination. J Anal Toxicol. 1997;21(1):54-8.
Hara, K., Kashimura, S., Hieda, Y., & Kageura, M. (1997). Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination. Journal of Analytical Toxicology, 21(1), 54-8.
Hara K, et al. Simple Extractive Derivatization of Methamphetamine and Its Metabolites in Biological Materials With Extrelut Columns for Their GC-MS Determination. J Anal Toxicol. 1997 Jan-Feb;21(1):54-8. PubMed PMID: 9013294.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Simple extractive derivatization of methamphetamine and its metabolites in biological materials with Extrelut columns for their GC-MS determination. AU - Hara,K, AU - Kashimura,S, AU - Hieda,Y, AU - Kageura,M, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 54 EP - 8 JF - Journal of analytical toxicology JO - J Anal Toxicol VL - 21 IS - 1 N2 - A simple, extractive heptafluoro-n-butyrylation with Extrelut columns was devised to simultaneously measure methamphetamine (MAMP), amphetamine (AMP), 4-hydroxymethamphetamine (HMAMP), and 4-hydroxyamphetamine (HAMP) in biological materials by gas chromatography-mass spectrometry (GC-MS) using 4-methoxymethamphetamine-d5 as the internal standard. Human urine, human whole blood, and porcine skeletal muscle spiked with the stimulant standards were used for evaluating the method. After deproteinization and adjustment of the pH to 12.6, the sample was applied to an Extrelut column. Using the present method, AMP, MAMP, and HMAMP could be determined in an actual forensic case study. SN - 0146-4760 UR - https://www.unboundmedicine.com/medline/citation/9013294/Simple_extractive_derivatization_of_methamphetamine_and_its_metabolites_in_biological_materials_with_Extrelut_columns_for_their_GC_MS_determination_ L2 - https://academic.oup.com/jat/article-lookup/doi/10.1093/jat/21.1.54 DB - PRIME DP - Unbound Medicine ER -