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Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases.
J Immunogenet. 1977 Jun; 4(3):167-75.JI

Abstract

Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81-4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset. In addition to B27, another HLA antigen may be associated with AS; the antigen Bw 16 was found to be significantly increased in B27 negative AS patients. HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bwel disease (IBD). In fifty-eight ulcerative colitis (UC) patients a raised incidence of A 11 was noticed. In fifty-one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty-nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly diffrent from B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD and increased frequency of Bw16 was also shown.

Authors

van den Berg-Loonen EM
No affiliation info available
Dekker-Saeys BJ
No affiliation info available
Meuwissen SG
No affiliation info available
Nijenhuis LE
No affiliation info available
Engelfriet CP
No affiliation info available

MeSH

Colitis, UlcerativeCrohn DiseaseHLA AntigensHistocompatibility AntigensHistocompatibility TestingHumansKell Blood-Group SystemSpondylitis, Ankylosing

Pub Type(s)

Journal Article

Language

eng

PubMed ID

901632

Citation

van den Berg-Loonen, E M., et al. "Histocompatibility Antigens and Other Genetic Markers in Ankylosing Spondylitis and Inflammatory Bowel Diseases." Journal of Immunogenetics, vol. 4, no. 3, 1977, pp. 167-75.
van den Berg-Loonen EM, Dekker-Saeys BJ, Meuwissen SG, et al. Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases. J Immunogenet. 1977;4(3):167-75.
van den Berg-Loonen, E. M., Dekker-Saeys, B. J., Meuwissen, S. G., Nijenhuis, L. E., & Engelfriet, C. P. (1977). Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases. Journal of Immunogenetics, 4(3), 167-75.
van den Berg-Loonen EM, et al. Histocompatibility Antigens and Other Genetic Markers in Ankylosing Spondylitis and Inflammatory Bowel Diseases. J Immunogenet. 1977;4(3):167-75. PubMed PMID: 901632.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Histocompatibility antigens and other genetic markers in ankylosing spondylitis and inflammatory bowel diseases. AU - van den Berg-Loonen,E M, AU - Dekker-Saeys,B J, AU - Meuwissen,S G, AU - Nijenhuis,L E, AU - Engelfriet,C P, PY - 1977/6/1/pubmed PY - 1977/6/1/medline PY - 1977/6/1/entrez SP - 167 EP - 75 JF - Journal of immunogenetics JO - J Immunogenet VL - 4 IS - 3 N2 - Of 118 Dutch patients suffering from ankylosing spondylitis (AS) 81-4% were found to be positive for the HLA antigen B27. The B27 frequency proved to be significantly higher in patients in whom the disease had an early onset. In addition to B27, another HLA antigen may be associated with AS; the antigen Bw 16 was found to be significantly increased in B27 negative AS patients. HLA phenotype frequencies were also determined in 109 patients with idiopathic inflammatory bwel disease (IBD). In fifty-eight ulcerative colitis (UC) patients a raised incidence of A 11 was noticed. In fifty-one patients with Crohn's disease (CD) the antigen B18 showed an increased frequency. Both deviations were statistically significant. In thirty-nine patients suffering from both AS and IBD 50% proved to be B27 positive, which is significantly diffrent from B27 frequency in patients with AS alone. In the B27 negative patients with AS and IBD and increased frequency of Bw16 was also shown. SN - 0305-1811 UR - https://www.unboundmedicine.com/medline/citation/901632/Histocompatibility_antigens_and_other_genetic_markers_in_ankylosing_spondylitis_and_inflammatory_bowel_diseases_ L2 - https://www.diseaseinfosearch.org/result/9679 DB - PRIME DP - Unbound Medicine ER -