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The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles.
Biol Psychiatry 1997; 41(2):191-5BP

Abstract

The apolipoprotein E (APOE) epsilon 4 allele is associated with an increased and the epsilon 2 allele a decreased risk for Alzheimer's disease (AD). It has been hypothesized that these risks are mediated by differential effects of the APOE alleles on the cytoskeletal degeneration, which results in neurofibrillary tangle (NFT) formation. It has also been suggested that APOE alleles differentially affect the beta amyloid accumulation. We examined APOE genotypes and their effects on age of onset in a family with an autosomal dominant "neurofibrillary tangle only" dementia. This disorder is manifested by schizophreniform psychosis followed by progressive dementia and neuropathologically by prominent AD-like neurofibrillary tangles without neuritic plaques. The only affected epsilon 4 heterozygote in this family did not demonstrate accelerated disease onset. In contrast, the affected epsilon 2 heterozygote had the latest age of onset of any affected family member. The two other epsilon 2 heterozygotes remained unaffected at an age much greater than the mean age of onset for the disease. These results are consistent with a protective effect of the epsilon 2 allele in a hereditary neuropsychiatric disorder with prominent NFT formation.

Authors+Show Affiliations

VA Puget Sound Health Care System, Psychiatry Service, Seattle, WA 98195, USA.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, U.S. Gov't, Non-P.H.S.
Research Support, U.S. Gov't, P.H.S.

Language

eng

PubMed ID

9018389

Citation

Tsuang, D, et al. "The Effect of Apolipoprotein E Genotype On Expression of an Autosomal Dominant Schizophreniform Disorder With Progressive Dementia and Neurofibrillary Tangles." Biological Psychiatry, vol. 41, no. 2, 1997, pp. 191-5.
Tsuang D, Raskind MA, Leverenz J, et al. The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biol Psychiatry. 1997;41(2):191-5.
Tsuang, D., Raskind, M. A., Leverenz, J., Peskind, E. R., Schellenberg, G., & Bird, T. D. (1997). The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. Biological Psychiatry, 41(2), pp. 191-5.
Tsuang D, et al. The Effect of Apolipoprotein E Genotype On Expression of an Autosomal Dominant Schizophreniform Disorder With Progressive Dementia and Neurofibrillary Tangles. Biol Psychiatry. 1997 Jan 15;41(2):191-5. PubMed PMID: 9018389.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The effect of apolipoprotein E genotype on expression of an autosomal dominant schizophreniform disorder with progressive dementia and neurofibrillary tangles. AU - Tsuang,D, AU - Raskind,M A, AU - Leverenz,J, AU - Peskind,E R, AU - Schellenberg,G, AU - Bird,T D, PY - 1997/1/15/pubmed PY - 1997/1/15/medline PY - 1997/1/15/entrez SP - 191 EP - 5 JF - Biological psychiatry JO - Biol. Psychiatry VL - 41 IS - 2 N2 - The apolipoprotein E (APOE) epsilon 4 allele is associated with an increased and the epsilon 2 allele a decreased risk for Alzheimer's disease (AD). It has been hypothesized that these risks are mediated by differential effects of the APOE alleles on the cytoskeletal degeneration, which results in neurofibrillary tangle (NFT) formation. It has also been suggested that APOE alleles differentially affect the beta amyloid accumulation. We examined APOE genotypes and their effects on age of onset in a family with an autosomal dominant "neurofibrillary tangle only" dementia. This disorder is manifested by schizophreniform psychosis followed by progressive dementia and neuropathologically by prominent AD-like neurofibrillary tangles without neuritic plaques. The only affected epsilon 4 heterozygote in this family did not demonstrate accelerated disease onset. In contrast, the affected epsilon 2 heterozygote had the latest age of onset of any affected family member. The two other epsilon 2 heterozygotes remained unaffected at an age much greater than the mean age of onset for the disease. These results are consistent with a protective effect of the epsilon 2 allele in a hereditary neuropsychiatric disorder with prominent NFT formation. SN - 0006-3223 UR - https://www.unboundmedicine.com/medline/citation/9018389/The_effect_of_apolipoprotein_E_genotype_on_expression_of_an_autosomal_dominant_schizophreniform_disorder_with_progressive_dementia_and_neurofibrillary_tangles_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0006-3223(96)00119-9 DB - PRIME DP - Unbound Medicine ER -