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Murine autoimmune gastritis and the gastric H,K-ATPase: insights from a new model and autoantibody detection system.
Verh Dtsch Ges Pathol 1996; 80:191-5VD

Abstract

Human type A chronic gastritis or autoimmune gastritis (AIG) is associated with gastric H,K-ATPase-specific autoantibodies (HKAb). The pathogenic role of the HKAb and the triggering autoantigen(s) are unknown. In a mouse model, neonatal thymectomy (nTx) induces AIG, which is likely T cell mediated, although HKAb are always present. Our aim is to study the role of the H,K-ATPase in the initiation of AIG. The direct involvement of the H,K-ATPase in the onset of AIG is suggested by the following findings. AIG appears at the age of 1 month in susceptible BALB.D2 mice, i.e. the time at which H,K-ATPase expression reaches adult levels. A new HKAb assay system based on immunoprecipitation of native H,K-ATPase expressed in Xenopus oocytes has revealed that the early lesion is already associated with low titers of HKAb. Injection of gastric membranes, rich in H,K-ATPase, into neonatal BALB.D2 mice without adjuvant induces a persisting AIG. This new model for AIG will provide the means to identify which H,K-ATPase subunit triggers AIG.

Authors+Show Affiliations

Swiss Institute for Experimental Cancer Research, University of Lausanne, Switzerland.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9020572

Citation

Claeys, D, et al. "Murine Autoimmune Gastritis and the Gastric H,K-ATPase: Insights From a New Model and Autoantibody Detection System." Verhandlungen Der Deutschen Gesellschaft Fur Pathologie, vol. 80, 1996, pp. 191-5.
Claeys D, Saraga E, Kraehenbuhl JP. Murine autoimmune gastritis and the gastric H,K-ATPase: insights from a new model and autoantibody detection system. Verh Dtsch Ges Pathol. 1996;80:191-5.
Claeys, D., Saraga, E., & Kraehenbuhl, J. P. (1996). Murine autoimmune gastritis and the gastric H,K-ATPase: insights from a new model and autoantibody detection system. Verhandlungen Der Deutschen Gesellschaft Fur Pathologie, 80, pp. 191-5.
Claeys D, Saraga E, Kraehenbuhl JP. Murine Autoimmune Gastritis and the Gastric H,K-ATPase: Insights From a New Model and Autoantibody Detection System. Verh Dtsch Ges Pathol. 1996;80:191-5. PubMed PMID: 9020572.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Murine autoimmune gastritis and the gastric H,K-ATPase: insights from a new model and autoantibody detection system. AU - Claeys,D, AU - Saraga,E, AU - Kraehenbuhl,J P, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 191 EP - 5 JF - Verhandlungen der Deutschen Gesellschaft fur Pathologie JO - Verh Dtsch Ges Pathol VL - 80 N2 - Human type A chronic gastritis or autoimmune gastritis (AIG) is associated with gastric H,K-ATPase-specific autoantibodies (HKAb). The pathogenic role of the HKAb and the triggering autoantigen(s) are unknown. In a mouse model, neonatal thymectomy (nTx) induces AIG, which is likely T cell mediated, although HKAb are always present. Our aim is to study the role of the H,K-ATPase in the initiation of AIG. The direct involvement of the H,K-ATPase in the onset of AIG is suggested by the following findings. AIG appears at the age of 1 month in susceptible BALB.D2 mice, i.e. the time at which H,K-ATPase expression reaches adult levels. A new HKAb assay system based on immunoprecipitation of native H,K-ATPase expressed in Xenopus oocytes has revealed that the early lesion is already associated with low titers of HKAb. Injection of gastric membranes, rich in H,K-ATPase, into neonatal BALB.D2 mice without adjuvant induces a persisting AIG. This new model for AIG will provide the means to identify which H,K-ATPase subunit triggers AIG. SN - 0070-4113 UR - https://www.unboundmedicine.com/medline/citation/9020572/Murine_autoimmune_gastritis_and_the_gastric_HK_ATPase:_insights_from_a_new_model_and_autoantibody_detection_system_ L2 - https://medlineplus.gov/autoimmunediseases.html DB - PRIME DP - Unbound Medicine ER -