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The possible role of yeast cell walls in modifying cellular response to chlorhexidine diacetate.
Cytobios. 1996; 86(345):123-35.C

Abstract

The relative porosity (RP) and thickness of cell walls of Saccharomyces cerevisiae depended upon the age of culture, the RP decreasing and the cell wall thickness increasing in older cultures. Chlorhexidine diacetate (CHA) produced cytological changes in S. cerevisiae cells, involving dense and granular cytoplasmic constituents, withdrawal of the interior from the cell wall and a general loss of the typical cellular organization. Cell wall mannan is unlikely to play a role in limiting the entry of CHA into yeast cells but changes in glucan composition, wall thickness and RP might be involved in determining the sensitivity of cells to the biguanide.

Authors+Show Affiliations

Hiom SJ
Welsh School of Pharmacy, University of Wales, Cardiff, Great Britain.
Furr JR
No affiliation info available
Russell AD
No affiliation info available
Hann AC
No affiliation info available

MeSH

Anti-Infective Agents, LocalBiological TransportCell WallChlorhexidineDisinfectantsGlucansMannansMicroscopy, ElectronPermeabilitySaccharomyces cerevisiae

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9022261

Citation

Hiom, S J., et al. "The Possible Role of Yeast Cell Walls in Modifying Cellular Response to Chlorhexidine Diacetate." Cytobios, vol. 86, no. 345, 1996, pp. 123-35.
Hiom SJ, Furr JR, Russell AD, et al. The possible role of yeast cell walls in modifying cellular response to chlorhexidine diacetate. Cytobios. 1996;86(345):123-35.
Hiom, S. J., Furr, J. R., Russell, A. D., & Hann, A. C. (1996). The possible role of yeast cell walls in modifying cellular response to chlorhexidine diacetate. Cytobios, 86(345), 123-35.
Hiom SJ, et al. The Possible Role of Yeast Cell Walls in Modifying Cellular Response to Chlorhexidine Diacetate. Cytobios. 1996;86(345):123-35. PubMed PMID: 9022261.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The possible role of yeast cell walls in modifying cellular response to chlorhexidine diacetate. AU - Hiom,S J, AU - Furr,J R, AU - Russell,A D, AU - Hann,A C, PY - 1996/1/1/pubmed PY - 1996/1/1/medline PY - 1996/1/1/entrez SP - 123 EP - 35 JF - Cytobios JO - Cytobios VL - 86 IS - 345 N2 - The relative porosity (RP) and thickness of cell walls of Saccharomyces cerevisiae depended upon the age of culture, the RP decreasing and the cell wall thickness increasing in older cultures. Chlorhexidine diacetate (CHA) produced cytological changes in S. cerevisiae cells, involving dense and granular cytoplasmic constituents, withdrawal of the interior from the cell wall and a general loss of the typical cellular organization. Cell wall mannan is unlikely to play a role in limiting the entry of CHA into yeast cells but changes in glucan composition, wall thickness and RP might be involved in determining the sensitivity of cells to the biguanide. SN - 0011-4529 UR - https://www.unboundmedicine.com/medline/citation/9022261/The_possible_role_of_yeast_cell_walls_in_modifying_cellular_response_to_chlorhexidine_diacetate_ DB - PRIME DP - Unbound Medicine ER -