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Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat.
Am J Obstet Gynecol. 1997 Jan; 176(1 Pt 1):73-6.AJ

Abstract

OBJECTIVE

Our purpose was to investigate the hypothesis that endothelin plays a critical role in maternal hypoxia-induced intrauterine growth restriction.

STUDY DESIGN

Chronic indwelling venous and arterial catheters were placed on day 17 of a 22-day gestation in timed-pregnant Sprague-Dawley rats. Twelve rats were infused with saline solution and 12 with 6 mg/kg per day FR139317, an endothelin receptor A-specific antagonist. For gestational days 18 to 21 half the rats in each infusion group were housed in a normoxic environment and the other half in a hypoxic (14% oxygen) environment. On day 21 an arterial blood gas level was determined, the rats were then anesthetized, and a hysterotomy was performed. The weight of each pup and its corresponding placenta was recorded. Statistical significance was determined by analysis of variance.

RESULTS

Among the rats receiving saline solution infusions, fetal weights were 20% less and placental weights were 11% less for those housed in a hypoxic environment compared with those housed in a normoxic environment (p < 0.003). Among the rats receiving FR139317 infusions, fetal and placental weights were not significantly different for those in a hypoxic environment compared with those in a normoxic environment. The fetal and placental weights for the rats receiving FR139317 infusion in hypoxic or normoxic environments were similar to those receiving saline solution in a normoxic environment.

CONCLUSIONS

Endothelin plays a critical role in hypoxia-induced intrauterine growth restriction. Infusion of an endothelin antagonist prevents the intrauterine growth restriction caused by chronic hypoxia.

Authors+Show Affiliations

Department of Obstetrics and Gynecology, Northwestern University Medical School, Evanston Hospital, IL 60201, USA.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article

Language

eng

PubMed ID

9024092

Citation

Thaete, L G., et al. "Endothelin Receptor a Antagonism Prevents Hypoxia-induced Intrauterine Growth Restriction in the Rat." American Journal of Obstetrics and Gynecology, vol. 176, no. 1 Pt 1, 1997, pp. 73-6.
Thaete LG, Neerhof MG, Caplan MS. Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. Am J Obstet Gynecol. 1997;176(1 Pt 1):73-6.
Thaete, L. G., Neerhof, M. G., & Caplan, M. S. (1997). Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. American Journal of Obstetrics and Gynecology, 176(1 Pt 1), 73-6.
Thaete LG, Neerhof MG, Caplan MS. Endothelin Receptor a Antagonism Prevents Hypoxia-induced Intrauterine Growth Restriction in the Rat. Am J Obstet Gynecol. 1997;176(1 Pt 1):73-6. PubMed PMID: 9024092.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Endothelin receptor A antagonism prevents hypoxia-induced intrauterine growth restriction in the rat. AU - Thaete,L G, AU - Neerhof,M G, AU - Caplan,M S, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 73 EP - 6 JF - American journal of obstetrics and gynecology JO - Am J Obstet Gynecol VL - 176 IS - 1 Pt 1 N2 - OBJECTIVE: Our purpose was to investigate the hypothesis that endothelin plays a critical role in maternal hypoxia-induced intrauterine growth restriction. STUDY DESIGN: Chronic indwelling venous and arterial catheters were placed on day 17 of a 22-day gestation in timed-pregnant Sprague-Dawley rats. Twelve rats were infused with saline solution and 12 with 6 mg/kg per day FR139317, an endothelin receptor A-specific antagonist. For gestational days 18 to 21 half the rats in each infusion group were housed in a normoxic environment and the other half in a hypoxic (14% oxygen) environment. On day 21 an arterial blood gas level was determined, the rats were then anesthetized, and a hysterotomy was performed. The weight of each pup and its corresponding placenta was recorded. Statistical significance was determined by analysis of variance. RESULTS: Among the rats receiving saline solution infusions, fetal weights were 20% less and placental weights were 11% less for those housed in a hypoxic environment compared with those housed in a normoxic environment (p < 0.003). Among the rats receiving FR139317 infusions, fetal and placental weights were not significantly different for those in a hypoxic environment compared with those in a normoxic environment. The fetal and placental weights for the rats receiving FR139317 infusion in hypoxic or normoxic environments were similar to those receiving saline solution in a normoxic environment. CONCLUSIONS: Endothelin plays a critical role in hypoxia-induced intrauterine growth restriction. Infusion of an endothelin antagonist prevents the intrauterine growth restriction caused by chronic hypoxia. SN - 0002-9378 UR - https://www.unboundmedicine.com/medline/citation/9024092/Endothelin_receptor_A_antagonism_prevents_hypoxia_induced_intrauterine_growth_restriction_in_the_rat_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0002937897706525 DB - PRIME DP - Unbound Medicine ER -