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[Smoldering leukemia with CD7.CD34(+), immunoglobulin heavy chain rearrangement (+) and hypoplastic marrow with myelofibrosis].
Rinsho Ketsueki. 1997 Jan; 38(1):21-7.RK

Abstract

A 63-year-old male was admitted because of pneumonia. Peripheral blood findings showed pancytopenia with increase of blasts. A bone marrow specimen showed hypocellular marrow with increase of blasts. The blasts were positive for CD7, CD34, and HLA-DR and negative for other lymphoid antigens and myeloid antigens involving myeloperoxidase. Rearrangement of immunoglobulin heavy chain was demonstrated by Southern blotting analysis. T cell receptor beta, T cell receptor gamma and immunoglobulin light chain rearrangement were negative. A diagnosis of stem cell leukemia was made. In vitro, the blasts did not respond to recombinant human granulocyte colony-stimulating factor (rhG-CSF), cytarabine (Ara-C) and all-trans retinoic acid (ATRA). However, in the blasts of culture without cytokeins, CD33 expression was newly induced. Remission was not obtained by chemotherapies with cyclophosphamide, etoposide, prednisolone and Ara-C. Four months later, marrow specimens showed hypoplasty with myelofibrosis. One year later, the blasts showed CD33 expression with negative myeloperoxidase. The leukemia was transformed to minimally differentiated myeloid leukemia from stem cell leukemia. This condition was thought to be "smoldering leukemia" because of the slow development and refractoriness to chemotherapy. Nineteen months later the patient died due to respiratory failure by pneumonia and pulmonary bleeding despite therapy.

Authors+Show Affiliations

First Department of Internal Medicine, Gifu University School of Medicine.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Case Reports
English Abstract
Journal Article

Language

jpn

PubMed ID

9028157

Citation

Hara, T, et al. "[Smoldering Leukemia With CD7.CD34(+), Immunoglobulin Heavy Chain Rearrangement (+) and Hypoplastic Marrow With Myelofibrosis]." [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, vol. 38, no. 1, 1997, pp. 21-7.
Hara T, Tsurumi H, Yamada T, et al. [Smoldering leukemia with CD7.CD34(+), immunoglobulin heavy chain rearrangement (+) and hypoplastic marrow with myelofibrosis]. Rinsho Ketsueki. 1997;38(1):21-7.
Hara, T., Tsurumi, H., Yamada, T., Sawada, M., Naito, T., Murakami, N., Moriwaki, H., & Muto, Y. (1997). [Smoldering leukemia with CD7.CD34(+), immunoglobulin heavy chain rearrangement (+) and hypoplastic marrow with myelofibrosis]. [Rinsho Ketsueki] the Japanese Journal of Clinical Hematology, 38(1), 21-7.
Hara T, et al. [Smoldering Leukemia With CD7.CD34(+), Immunoglobulin Heavy Chain Rearrangement (+) and Hypoplastic Marrow With Myelofibrosis]. Rinsho Ketsueki. 1997;38(1):21-7. PubMed PMID: 9028157.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - [Smoldering leukemia with CD7.CD34(+), immunoglobulin heavy chain rearrangement (+) and hypoplastic marrow with myelofibrosis]. AU - Hara,T, AU - Tsurumi,H, AU - Yamada,T, AU - Sawada,M, AU - Naito,T, AU - Murakami,N, AU - Moriwaki,H, AU - Muto,Y, PY - 1997/1/1/pubmed PY - 1997/1/1/medline PY - 1997/1/1/entrez SP - 21 EP - 7 JF - [Rinsho ketsueki] The Japanese journal of clinical hematology JO - Rinsho Ketsueki VL - 38 IS - 1 N2 - A 63-year-old male was admitted because of pneumonia. Peripheral blood findings showed pancytopenia with increase of blasts. A bone marrow specimen showed hypocellular marrow with increase of blasts. The blasts were positive for CD7, CD34, and HLA-DR and negative for other lymphoid antigens and myeloid antigens involving myeloperoxidase. Rearrangement of immunoglobulin heavy chain was demonstrated by Southern blotting analysis. T cell receptor beta, T cell receptor gamma and immunoglobulin light chain rearrangement were negative. A diagnosis of stem cell leukemia was made. In vitro, the blasts did not respond to recombinant human granulocyte colony-stimulating factor (rhG-CSF), cytarabine (Ara-C) and all-trans retinoic acid (ATRA). However, in the blasts of culture without cytokeins, CD33 expression was newly induced. Remission was not obtained by chemotherapies with cyclophosphamide, etoposide, prednisolone and Ara-C. Four months later, marrow specimens showed hypoplasty with myelofibrosis. One year later, the blasts showed CD33 expression with negative myeloperoxidase. The leukemia was transformed to minimally differentiated myeloid leukemia from stem cell leukemia. This condition was thought to be "smoldering leukemia" because of the slow development and refractoriness to chemotherapy. Nineteen months later the patient died due to respiratory failure by pneumonia and pulmonary bleeding despite therapy. SN - 0485-1439 UR - https://www.unboundmedicine.com/medline/citation/9028157/[Smoldering_leukemia_with_CD7_CD34_+__immunoglobulin_heavy_chain_rearrangement__+__and_hypoplastic_marrow_with_myelofibrosis]_ L2 - http://www.diseaseinfosearch.org/result/5022 DB - PRIME DP - Unbound Medicine ER -