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PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells.
J Lipid Mediat Cell Signal. 1996 Dec; 15(1):1-4.JL

Abstract

Platelet-activating factor (PAF) is present in human bone marrow leading us to investigate its effect on human bone marrow cell proliferation. While PAF (0.1 microM to 1 nM) stimulates the incorporation of [3H]thymidine by freshly isolated adherent human bone marrow cells, PAF has no effect on non adherent cells. A non-metabolizable PAF agonist is more potent than PAF to stimulate thymidine incorporation in adherent cells. The precise role of PAF in human haematopoiesis in vivo remains to be clarified.

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Authors+Show Affiliations

Denizot Y
Laboratoire d'Hématologie Expénmentale, Faculté de Médecine, Limoges, France.
Dupuis F
No affiliation info available
Trimoreau F
No affiliation info available
Verger C
No affiliation info available
Allegraud A
No affiliation info available
Praloran V
No affiliation info available

MeSH

Bone MarrowBone Marrow CellsCells, CulturedDNAHematopoiesisHumansPlatelet Activating FactorThymidineTritium

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9029369

Citation

Denizot, Y, et al. "PAF and Haematopoiesis: IX. Platelet-activating Factor Increases DNA Synthesis in Human Bone Marrow Cells." Journal of Lipid Mediators and Cell Signalling, vol. 15, no. 1, 1996, pp. 1-4.
Denizot Y, Dupuis F, Trimoreau F, et al. PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. J Lipid Mediat Cell Signal. 1996;15(1):1-4.
Denizot, Y., Dupuis, F., Trimoreau, F., Verger, C., Allegraud, A., & Praloran, V. (1996). PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. Journal of Lipid Mediators and Cell Signalling, 15(1), 1-4.
Denizot Y, et al. PAF and Haematopoiesis: IX. Platelet-activating Factor Increases DNA Synthesis in Human Bone Marrow Cells. J Lipid Mediat Cell Signal. 1996;15(1):1-4. PubMed PMID: 9029369.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - PAF and haematopoiesis: IX. Platelet-activating factor increases DNA synthesis in human bone marrow cells. AU - Denizot,Y, AU - Dupuis,F, AU - Trimoreau,F, AU - Verger,C, AU - Allegraud,A, AU - Praloran,V, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 1 EP - 4 JF - Journal of lipid mediators and cell signalling JO - J Lipid Mediat Cell Signal VL - 15 IS - 1 N2 - Platelet-activating factor (PAF) is present in human bone marrow leading us to investigate its effect on human bone marrow cell proliferation. While PAF (0.1 microM to 1 nM) stimulates the incorporation of [3H]thymidine by freshly isolated adherent human bone marrow cells, PAF has no effect on non adherent cells. A non-metabolizable PAF agonist is more potent than PAF to stimulate thymidine incorporation in adherent cells. The precise role of PAF in human haematopoiesis in vivo remains to be clarified. SN - 0929-7855 UR - https://www.unboundmedicine.com/medline/citation/9029369/PAF_and_haematopoiesis:_IX__Platelet_activating_factor_increases_DNA_synthesis_in_human_bone_marrow_cells_ L2 - https://linkinghub.elsevier.com/retrieve/pii/S0929785596004476 DB - PRIME DP - Unbound Medicine ER -