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The influence of alcohol consumption on worldwide trends in mortality from upper aerodigestive tract cancers in men.
J Epidemiol Community Health 1996; 50(6):636-9JE

Abstract

STUDY OBJECTIVES

To assess current trends in male mortality from cancers of the oral cavity/pharynx, oesophagus, and larynx (upper aerodigestive tract cancers), and relate these to past national consumption of alcohol and smoking of cigarettes. To assess the impact of current trends in alcohol consumption and tobacco smoking on likely future rates of these cancers.

DESIGN

Mortality data for cancers of the oral cavity/pharynx, oesophagus, and larynx were obtained for the years 1955-89 in 25 countries located in North America, Australasia, Europe, and Japan. Information on past and current alcohol consumption was also obtained for these countries, while current national lung cancer rates were used as a proxy measure of past smoking levels.

SETTING

The World Health Organization mortality database.

MAIN RESULTS

National death rates from cancers of the oral cavity/pharynx, oesophagus, and larynx (considered together) are currently increasing among men and are most strongly associated with the level of per capita consumption of alcohol 20 years previously. They were less strongly associated with the level of alcohol consumption 10 years ago, and only very weakly associated with the current level of lung cancer mortality (a marker of past smoking habits). Regression analysis showed that the national rate of upper aerodigestive tract cancer could be estimated using information on past alcohol consumption and an interaction term between alcohol consumption and current lung cancer rates. Assuming stability in rates of lung cancer, the sizeable increase in alcohol consumption from 5 to 10 litres per capita each year that occurred in some countries during the 1960s and 70s means that increases of around 5 per 100,000 in the death rate from these cancers can be expected in these countries in the next decades.

CONCLUSIONS

Previous alcohol consumption in a country is a strong predictor of deaths from cancers of the upper aerodigestive tract in men, and current increases in death rates can probably be related to increases in consumption which took place during the 1960s and 70s. Combined with a reduction in tobacco smoking, which is already taking place in some countries, reversing the trend of increases in consumption of alcohol has the potential for a sizeable impact on the burden of these cancers.

Authors+Show Affiliations

ARC Epidemiology Research Unit, School of Epidemiology and Health Sciences, University of Manchester.No affiliation info availableNo affiliation info available

Pub Type(s)

Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9039382

Citation

Macfarlane, G J., et al. "The Influence of Alcohol Consumption On Worldwide Trends in Mortality From Upper Aerodigestive Tract Cancers in Men." Journal of Epidemiology and Community Health, vol. 50, no. 6, 1996, pp. 636-9.
Macfarlane GJ, Macfarlane TV, Lowenfels AB. The influence of alcohol consumption on worldwide trends in mortality from upper aerodigestive tract cancers in men. J Epidemiol Community Health. 1996;50(6):636-9.
Macfarlane, G. J., Macfarlane, T. V., & Lowenfels, A. B. (1996). The influence of alcohol consumption on worldwide trends in mortality from upper aerodigestive tract cancers in men. Journal of Epidemiology and Community Health, 50(6), pp. 636-9.
Macfarlane GJ, Macfarlane TV, Lowenfels AB. The Influence of Alcohol Consumption On Worldwide Trends in Mortality From Upper Aerodigestive Tract Cancers in Men. J Epidemiol Community Health. 1996;50(6):636-9. PubMed PMID: 9039382.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - The influence of alcohol consumption on worldwide trends in mortality from upper aerodigestive tract cancers in men. AU - Macfarlane,G J, AU - Macfarlane,T V, AU - Lowenfels,A B, PY - 1996/12/1/pubmed PY - 1996/12/1/medline PY - 1996/12/1/entrez SP - 636 EP - 9 JF - Journal of epidemiology and community health JO - J Epidemiol Community Health VL - 50 IS - 6 N2 - STUDY OBJECTIVES: To assess current trends in male mortality from cancers of the oral cavity/pharynx, oesophagus, and larynx (upper aerodigestive tract cancers), and relate these to past national consumption of alcohol and smoking of cigarettes. To assess the impact of current trends in alcohol consumption and tobacco smoking on likely future rates of these cancers. DESIGN: Mortality data for cancers of the oral cavity/pharynx, oesophagus, and larynx were obtained for the years 1955-89 in 25 countries located in North America, Australasia, Europe, and Japan. Information on past and current alcohol consumption was also obtained for these countries, while current national lung cancer rates were used as a proxy measure of past smoking levels. SETTING: The World Health Organization mortality database. MAIN RESULTS: National death rates from cancers of the oral cavity/pharynx, oesophagus, and larynx (considered together) are currently increasing among men and are most strongly associated with the level of per capita consumption of alcohol 20 years previously. They were less strongly associated with the level of alcohol consumption 10 years ago, and only very weakly associated with the current level of lung cancer mortality (a marker of past smoking habits). Regression analysis showed that the national rate of upper aerodigestive tract cancer could be estimated using information on past alcohol consumption and an interaction term between alcohol consumption and current lung cancer rates. Assuming stability in rates of lung cancer, the sizeable increase in alcohol consumption from 5 to 10 litres per capita each year that occurred in some countries during the 1960s and 70s means that increases of around 5 per 100,000 in the death rate from these cancers can be expected in these countries in the next decades. CONCLUSIONS: Previous alcohol consumption in a country is a strong predictor of deaths from cancers of the upper aerodigestive tract in men, and current increases in death rates can probably be related to increases in consumption which took place during the 1960s and 70s. Combined with a reduction in tobacco smoking, which is already taking place in some countries, reversing the trend of increases in consumption of alcohol has the potential for a sizeable impact on the burden of these cancers. SN - 0143-005X UR - https://www.unboundmedicine.com/medline/citation/9039382/The_influence_of_alcohol_consumption_on_worldwide_trends_in_mortality_from_upper_aerodigestive_tract_cancers_in_men_ L2 - http://jech.bmj.com/cgi/pmidlookup?view=long&pmid=9039382 DB - PRIME DP - Unbound Medicine ER -