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Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women.
J Bone Miner Res. 1997 Feb; 12(2):241-7.JB

Abstract

It is well established that genetic factors contribute to bone turnover and bone density. Evidence exists suggesting that a major part of this genetic influence may be due to polymorphisms in the vitamin D receptor (VDR) gene. However, it is not clear whether the VDR genotype effect persists in elderly women. In the present study, the relationship between the BsmI, ApaI, and TaqI polymorphisms in the VDR gene, and the bone mineral density (BMD) at the lumbar spine, the femoral neck (FN), and the proximal radius was investigated in a large group of elderly women (75.5 +/- 5.0 years) of Caucasian origin and in 84 Type I osteoporotic women (66.6 +/- 8.4 years). We did not find a correlation between the VDR genotypes and BMD in elderly women. However, a significantly higher FN-BMD was observed in obese (body mass index [BMI] > 30 kg/m2) versus nonobese (BMI < 30 kg/m2) women (p < 0.01). This relationship was observed for all BsmI genotypes. Furthermore, the FN-BMD of nonobese women with bb BsmI genotype was 5% higher than that of women with the BB genotype (p = 0.04). We conclude that the VDR gene polymorphisms influence the FN-BMD in nonobese postmenopausal women. In a second part of the study, possible correlations between the VDR gene polymorphisms and osteoporosis Type I were analyzed. Our data could not reveal any association between these parameters.

Authors+Show Affiliations

Dr. L. Willems-Instituut, Diepenbeek, Belgium.No affiliation info availableNo affiliation info availableNo affiliation info availableNo affiliation info available

Pub Type(s)

Comparative Study
Journal Article
Research Support, Non-U.S. Gov't

Language

eng

PubMed ID

9041056

Citation

Vandevyver, C, et al. "Influence of the Vitamin D Receptor Gene Alleles On Bone Mineral Density in Postmenopausal and Osteoporotic Women." Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, vol. 12, no. 2, 1997, pp. 241-7.
Vandevyver C, Wylin T, Cassiman JJ, et al. Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. J Bone Miner Res. 1997;12(2):241-7.
Vandevyver, C., Wylin, T., Cassiman, J. J., Raus, J., & Geusens, P. (1997). Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. Journal of Bone and Mineral Research : the Official Journal of the American Society for Bone and Mineral Research, 12(2), 241-7.
Vandevyver C, et al. Influence of the Vitamin D Receptor Gene Alleles On Bone Mineral Density in Postmenopausal and Osteoporotic Women. J Bone Miner Res. 1997;12(2):241-7. PubMed PMID: 9041056.
* Article titles in AMA citation format should be in sentence-case
TY - JOUR T1 - Influence of the vitamin D receptor gene alleles on bone mineral density in postmenopausal and osteoporotic women. AU - Vandevyver,C, AU - Wylin,T, AU - Cassiman,J J, AU - Raus,J, AU - Geusens,P, PY - 1997/2/1/pubmed PY - 1997/2/1/medline PY - 1997/2/1/entrez SP - 241 EP - 7 JF - Journal of bone and mineral research : the official journal of the American Society for Bone and Mineral Research JO - J Bone Miner Res VL - 12 IS - 2 N2 - It is well established that genetic factors contribute to bone turnover and bone density. Evidence exists suggesting that a major part of this genetic influence may be due to polymorphisms in the vitamin D receptor (VDR) gene. However, it is not clear whether the VDR genotype effect persists in elderly women. In the present study, the relationship between the BsmI, ApaI, and TaqI polymorphisms in the VDR gene, and the bone mineral density (BMD) at the lumbar spine, the femoral neck (FN), and the proximal radius was investigated in a large group of elderly women (75.5 +/- 5.0 years) of Caucasian origin and in 84 Type I osteoporotic women (66.6 +/- 8.4 years). We did not find a correlation between the VDR genotypes and BMD in elderly women. However, a significantly higher FN-BMD was observed in obese (body mass index [BMI] > 30 kg/m2) versus nonobese (BMI < 30 kg/m2) women (p < 0.01). This relationship was observed for all BsmI genotypes. Furthermore, the FN-BMD of nonobese women with bb BsmI genotype was 5% higher than that of women with the BB genotype (p = 0.04). We conclude that the VDR gene polymorphisms influence the FN-BMD in nonobese postmenopausal women. In a second part of the study, possible correlations between the VDR gene polymorphisms and osteoporosis Type I were analyzed. Our data could not reveal any association between these parameters. SN - 0884-0431 UR - https://www.unboundmedicine.com/medline/citation/9041056/Influence_of_the_vitamin_D_receptor_gene_alleles_on_bone_mineral_density_in_postmenopausal_and_osteoporotic_women_ L2 - https://doi.org/10.1359/jbmr.1997.12.2.241 DB - PRIME DP - Unbound Medicine ER -